European Urology

Review Paper

Cellular Changes in Acute Renal Failure: Functional and Therapeutic Consequences

Hohenfellner M.a · Thüroff J.W.a · Thurau K.b

Author affiliations

(a) Department of Urology, Klinikum Barmen, Wuppertal, FRG; (b) Department of Physiology, University of Munich, FRG

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Eur Urol 1992;22:265–270

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Article / Publication Details

Published online: August 11, 2017
Issue release date: 1992

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0302-2838 (Print)
eISSN: 1873-7560 (Online)

For additional information: https://www.karger.com/EUR

Abstract

Prerenai, renal and postrenal forms of acute renal failure (ARF) are distinguishable. Prerenai forms are reversible by effective treatment of the underlying extrarenai disorder(s). Damage of the endothelium and the tubular epithelium indicates progress of prerenai to renal ARF or induction of primary renal ARF. A continuous survey of renal function based on the cellular and functional pathophysiologic pathways of ARF allows adequate and specific therapy. As both extra- and intrarenal causes of ARF may occur simultaneously under clinical conditions, a broad therapeutic approach should be used: treatment of the extrarenai disorder augmented by measures to reduce the cellular workload, cell-protective therapy, support of microcirculation rheology, and inhibition of prerenai vasoconstriction.




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Article / Publication Details

Published online: August 11, 2017
Issue release date: 1992

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0302-2838 (Print)
eISSN: 1873-7560 (Online)

For additional information: https://www.karger.com/EUR


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