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Clinical Practice: Mini-Review

Free Access

A Role of Remote Organs Effect in Acute Kidney Injury Outcome

Dépret F.a, b · Prud'homme M.b · Legrand M.a, b

Author affiliations

aDepartment of Anesthesiology and Critical Care and Burn Unit, AP-HP, St-Louis-Lariboisière Hospital, University Paris Diderot, and bINSERM UMR-S 942, Institute National de la Santé et de la Recherche Médicale (INSERM), Lariboisière Hospital, FCRIN INICRCT Network, Paris, France

Corresponding Author

Dr. Matthieu Legrand

Department of Anesthesiology and Critical Care and Burn Unit

St-Louis Hospital, Assistance Publique-Hôpitaux de Paris

1 Avenue Claude Vellefaux, FR-75010 (France)

E-Mail matthieu.legrand@aphp.fr

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Nephron 2017;137:273–276

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Abstract

Acute kidney injury (AKI) has been associated with both short- and long-term outcomes. To date, there is still a debate whether the increase risk of morbidity and mortality is directly due to AKI occurrence. There is, however, a potential causal impact of AKI on outcome, but evidence of this association is yet lacking. The hypothesis of remote organ damage and dysfunction (heart, lung, liver, brain, etc.) has emerged over the last decade and may explain the reason for the potential negative impact of AKI on outcome. The aim of this review was to describe findings concerning the remote effect of AKI in animal models and human studies.

© 2017 S. Karger AG, Basel


References

  1. Ali T, Khan I, Simpson W, Prescott G, Townend J, Smith W, et al: Incidence and outcomes in acute kidney injury: a comprehensive population-based study. J Am Soc Nephrol 2007;18:1292-1298.
  2. Bedford M, Stevens PE, Wheeler TW, Farmer CK: What is the real impact of acute kidney injury? BMC Nephrol 2014;15:95.
  3. Ostermann M, Chang RW: Acute kidney injury in the intensive care unit according to RIFLE. Crit Care Med 2007;35:1837-1843.
  4. De Corte W, Dhondt A, Vanholder R, De Waele J, Decruyenaere J, Sergoyne V, et al: Long-term outcome in ICU patients with acute kidney injury treated with renal replacement therapy: a prospective cohort study. Crit Care 2016;20:256.
  5. Sawhney S, Marks A, Fluck N, Levin A, Prescott G, Black C: Intermediate and long-term outcomes of survivors of acute kidney injury episodes: a large population-based cohort study. Am J Kidney Dis 2017;69:18-28.
  6. Wang HE, Muntner P, Chertow GM, Warnock DG: Acute kidney injury and mortality in hospitalized patients. Am J Nephrol 2012;35:349-355.
  7. Cruz DN, Bolgan I, Perazella MA, Bonello M, de Cal M, Corradi V, et al: North east Italian prospective hospital renal outcome survey on acute kidney injury (NEiPHROS-AKI): targeting the problem with the RIFLE criteria. Clin J Am Soc Nephrol 2007;2:418-425.
  8. Liangos O, et al: Epidemiology and outcomes of acute renal failure in hospitalized patients: a national survey. Clin J Am Soc Nephrol 2006;1:43-51.
  9. Chertow GM, et al: Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol 2005;16:3365-3370.
  10. Choi AI, Li Y, Parikh C, Volberding PA, Shlipak MG: Long-term clinical consequences of acute kidney injury in the HIV-infected. Kidney Int 2010;78:478-485.
  11. Grams ME, Rabb H: The distant organ effects of acute kidney injury. Kidney Int 2012;81:942-948.
  12. Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W, et al: Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci 2013;110:3507-3512.
  13. Hassoun HT, Grigoryev DN, Lie ML, Liu M, Cheadle C, Tuder RM, et al: Ischemic acute kidney injury induces a distant organ functional and genomic response distinguishable from bilateral nephrectomy. Am J Physiol Renal Physiol 2007;293:F30-F40.
  14. Brøchner AC, Dagnaes-Hansen F, Højberg-Holm J, Toft P: The inflammatory response in blood and in remote organs following acute kidney injury. APMIS 2014;122:399-404.
  15. Hoke TS, Douglas IS, Klein CL, He Z, Fang W, Thurman JM, et al: Acute renal failure after bilateral nephrectomy is associated with cytokine-mediated pulmonary injury. J Am Soc Nephrol 2007;18:155-164.
  16. Deng J, Hu X, Yuen PS, Star RA: Alpha-melanocyte-stimulating hormone inhibits lung injury after renal ischemia/reperfusion. Am J Respir Crit Care Med 2004;169:749-756.
  17. Hassoun HT, Lie ML, Grigoryev DN, Liu M, Tuder RM, Rabb H: Kidney ischemia-reperfusion injury induces caspase-dependent pulmonary apoptosis. Am J Physiol Renal Physiol 2009;297:F125-F137.
  18. Nakazawa D, Kumar SV, Marschner J, Desai J, Holderied A, Rath L, et al: Histones and neutrophil extracellular traps enhance tubular necrosis and remote organ injury in ischemic AKI. J Am Soc Nephrol 2017;pii:ASN.2016080925.
  19. Gardner DS, De Brot S, Dunford LJ, Grau-Roma L, Welham SJ, Fallman R, et al: Remote effects of acute kidney injury in a porcine model. Am J Physiol Renal Physiol 2016;310:F259-F271.
  20. Darmon M, Clec'h C, Adrie C, Argaud L, Allaouchiche B, Azoulay E, et al: Acute respiratory distress syndrome and risk of AKI among critically ill patients. Clin J Am Soc Nephrol 2014;9:1347-1353.
  21. Levy EM, Viscoli CM, Horwitz RI: The effect of acute renal failure on mortality. A cohort analysis. JAMA 1996;275:1489-1494.
  22. Vieira JM Jr, Castro I, Curvello-Neto A, Demarzo S, Caruso P, Pastore L, et al: Effect of acute kidney injury on weaning from mechanical ventilation in critically ill patients. Crit Care Med 2007;35:184-191.
  23. Liu KD, Glidden DV, Eisner MD, Parsons PE, Ware LB, Wheeler A, et al: Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Crit Care Med 2007;35:2755-2761.
  24. Kelly KJ: Distant effects of experimental renal ischemia/reperfusion injury. J Am Soc Nephrol 2003;14:1549-1558.
  25. Burchill L, Velkoska E, Dean RG, Lew RA, Smith AI, Levidiotis V, et al: Acute kidney injury in the rat causes cardiac remodelling and increases angiotensin-converting enzyme 2 expression. Exp Physiol 2008;93:622-630.
  26. González GE, Rhaleb NE, D'Ambrosio MA, Nakagawa P, Liao TD, Peterson EL, et al: Cardiac-deleterious role of galectin-3 in chronic angiotensin II-induced hypertension. Am J Physiol Heart Circ Physiol 2016;311:H1287-H1296.
  27. Di Lullo L, Bellasi A, Russo D, Cozzolino M, Ronco C: Cardiorenal acute kidney injury: epidemiology, presentation, causes, pathophysiology and treatment. Int J Cardiol 2017;227:143-150.
  28. Gambardella I, Gaudino M, Ronco C, Lau C, Ivascu N, Girardi LN: Congestive kidney failure in cardiac surgery: the relationship between central venous pressure and acute kidney injury. Interact Cardiovasc Thorac Surg 2016;23:800-805.
  29. Vasan RS: Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study. Circulation 2003;107:1486-1491.
  30. Setsuta K, Seino Y, Ogawa T, Ohtsuka T, Seimiya K, Takano T: Ongoing myocardial damage in chronic heart failure is related to activated tumor necrosis factor and Fas/Fas ligand system. Circ J 2004;68:747-750.
  31. Grupper A, Nativi-Nicolau J, Maleszewski JJ, Geske JR, Kremers WK, Edwards BS, et al: Circulating galectin-3 levels are persistently elevated after heart transplantation and are associated with renal dysfunction. JACC Heart Fail 2016;4:847-856.
  32. Golab F, Kadkhodaee M, Zahmatkesh M, Hedayati M, Arab H, Schuster R, et al: Ischemic and non-ischemic acute kidney injury cause hepatic damage. Kidney Int 2009;75:783-792.
  33. Park SW, Chen SW, Kim M, Brown KM, Kolls JK, D'Agati VD, et al: Cytokines induce small intestine and liver injury after renal ischemia or nephrectomy. Lab Invest 2011;91:63-84.
  34. Baraldi O, Valentini C, Donati G, Comai G, Cuna V, Capelli I, et al: Hepatorenal syndrome: update on diagnosis and treatment. World J Nephrol 2015;4:511-520.
  35. Lane K, Dixon JJ, MacPhee IA, Philips BJ: Renohepatic crosstalk: does acute kidney injury cause liver dysfunction? Nephrol Dial Transplant 2013;28:1634-1647.
  36. Johnson AC, Ware LB, Himmelfarb J, Zager RA: HMG-CoA reductase activation and urinary pellet cholesterol elevations in acute kidney injury. Clin J Am Soc Nephrol 2011;6:2108-2113.
  37. Belcher JM, Garcia-Tsao G, Sanyal AJ, Bhogal H, Lim JK, Ansari N, et al: Association of AKI with mortality and complications in hospitalized patients with cirrhosis. Hepatology 2013;57:753-762.

Article / Publication Details

First-Page Preview
Abstract of Clinical Practice: Mini-Review

Received: March 03, 2017
Accepted: April 21, 2017
Published online: June 07, 2017
Issue release date: Published online first

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF


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