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Clinical Practice: Mini-Review

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Nonpharmacological, Biomechanical Approaches to Control Inflammation in Acute Kidney Injury

Tanaka S.a · Inoue T.a · Hossack J.A.b · Okusa M.D.a

Author affiliations

aDivision of Nephrology and Center for Immunity, Inflammation, and Regenerative Medicine, and bDepartment of Biomedical Engineering, University of Virginia Health System, Charlottesville, VA, USA

Corresponding Author

Dr. Mark D. Okusa

Division of Nephrology and Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia Health System

PO Box 800133, Charlottesville, VA 22908 (USA)

E-Mail mdo7y@virginia.edu

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Nephron 2017;137:277–281

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Abstract

Inflammation is broadly recognized as an important factor in the pathogenesis of acute kidney injury (AKI), but pharmacological approaches to alleviate inflammation in AKI have been without success in clinical trials. Neuromodulation by nonpharmacological methods is emerging as a novel therapeutic strategy to treat inflammatory diseases. Recently, our group and others have demonstrated that vagus nerve stimulation and pulsed ultrasound ameliorated inflammation via the cholinergic anti-inflammatory pathway (CAP) in various animal models, including renal ischemia-reperfusion injury. Delineating the precise mechanisms by which these methods activate the CAP and ameliorate inflammation is mandatory for the broad clinical application in the future. Novel techniques, such as optogenetics, are expected to elucidate these complex mechanisms.

© 2017 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Clinical Practice: Mini-Review

Received: March 07, 2017
Accepted: May 02, 2017
Published online: June 09, 2017
Issue release date: Published online first

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF


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