Investigation of an Immediate Effect of Bright Light on Oxygen Consumption, Heart Rate, Cortisol, and α-Amylase in Seasonal Affective Disorder Subjects and Healthy ControlsIvanova I.A. · Danilenko K.V. · Aftanas L.I.
Institute of Physiology and Basic Medicine, Novosibirsk, Russia
Do you have an account?
- Rent for 48h to view
- Buy Cloud Access for unlimited viewing via different devices
- Synchronizing in the ReadCube Cloud
- Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00
Article / Publication Details
Background: Body (fat) mass has been shown to decrease following bright light treatment for overweight women, irrespective of their seasonal (light) dependence. It is not known if this is due to an (immediate) increase of metabolism. Methods: Ten women with seasonal affective disorder (SAD) and 10 non-SAD women matched by age, body mass index, and menopausal status participated in a laboratory study in the morning, twice within 1-5 days. During one session, bright light (4,300 lx) was presented for 30 min, and during the other session, red light (250 lx “placebo”) was used. After an initial 15 min of sitting quietly in an experimental chamber, 10-min measurements were done before, at the end, and 15 min after light exposure; the subjects remained seated for 80 min in total. The measurements included 5-min oxyspirography (oxygen consumption, carbon dioxide emission, and heart rate), saliva sampling for the estimation of cortisol and α-amylase concentrations, and self-rating of mood, energy, and sleepiness. Results: There was no light-specific effect on the measured variables, except that sleepiness was reduced more with bright light than with red light in the combined group. α-Amylase values were lower in the SAD patients than in the non-SAD controls. Conclusions: Morning artificial bright light, in comparison with dim red light, had no immediate effect on metabolism and resting sympathetic tone, though subjective sleepiness decreased more with bright light. SAD patients have low salivary α-amylase levels, indicating lower sympathetic tone.
© 2017 S. Karger AG, Basel
- Dunai A, Novak M, Chung SA, Kayumov L, Keszei A, Levitan R, Shapiro CM: Moderate exercise and bright light treatment in overweight and obese individuals. Obesity (Silver Spring) 2007;15:1749-1757.
- Danilenko KV, Mustafina SV, Pechyonkina EA: Bright light for weight loss: results of a controlled crossover trial. Obes Facts 2013;6:28-38.
- Gaist PA, Obarzanek E, Skwerer RG, Duncan CC, Shultz PM, Rosenthal NE: Effects of bright light on resting metabolic rate in patients with seasonal affective disorder and control subjects. Biol Psychiatry 1990;28:989-996.
- Pinchasov BB, Shurgaja AM, Grischin OV, Putilov AA: Mood and energy regulation in seasonal and non-seasonal depression before and after midday treatment with physical exercise or bright light. Psychiatry Res 2000;94:29-42.
- Rüger M, Scheer FA: Effects of circadian disruption on the cardiometabolic system. Rev Endocr Metab Disord 2009;10:245-260.
- Oldham MA, Ciraulo DA: Bright light therapy for depression: a review of its effects on chronobiology and the autonomic nervous system. Chronobiol Int 2014;31:305-319.
- Bosch JA1, Veerman EC, de Geus EJ, Proctor GB: α-Amylase as a reliable and convenient measure of sympathetic activity: don't start salivating just yet! Psychoneuroendocrinology 2011;36:449-453.
- Booij SH, Bos EH, Bouwmans ME, van Faassen M, Kema IP, Oldehinkel AJ, de Jonge P: Cortisol and α-amylase secretion patterns between and within depressed and non-depressed individuals. PLoS One 2015;10:e0131002.
- Figueiro MG, Rea MS: The effects of red and blue lights on circadian variations in cortisol, alpha amylase, and melatonin. Int J Endocrinol 2010;2010:829351.
- Sahin L, Wood BM, Plitnick B, Figueiro MG: Daytime light exposure: effects on biomarkers, measures of alertness, and performance. Behav Brain Res 2014;274:176-185.
- Danilenko KV, Sergeeva OY: Immediate effect of blue-enhanced light on reproductive hormones in women. Neuroendocrinol Lett 2015;36:84-90.
- Cajochen C, Zeitzer JM, Czeisler CA, Dijk DJ: Dose-response relationship for light intensity and ocular and electroencephalographic correlates of human alertness. Behav Brain Res 2000;115:75-83.
- Rüger M, Gordijn MC, Beersma DG, de Vries B, Daan S: Weak relationships between suppression of melatonin and suppression of sleepiness/fatigue in response to light exposure. J Sleep Res 2005;14:221-227.
- Rüger M, Gordijn MCM, Beersma DGM, de Vries B: Time-of-day-dependent effects of bright light exposure on human psychophysiology: comparison of daytime and nighttime exposure. Am J Physiol Regul Integr Comp Physiol 2006;290:1413-1420.
- Sasseville A, Martin JS, Houle J, Hébert M: Investigating the contribution of short wavelengths in the alerting effect of bright light. Physiol Behav 2015;151:81-87.
Wirz-Justice A, Benedetti F, Terman M: Chronotherapeutics for Affective Disorders: A Clinician's Manual for Light and Wake Therapy, ed 2, revised. Basel, Karger, 2013.
- Daneault V, Dumont M, Massé É, Vandewalle G, Carrier J: Light-sensitive brain pathways and aging. J Physiol Anthropol 2016;35:9.
American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, ed 4. Washington DC, American Psychiatric Press, 1994.
Rosenthal NE, Genhart MJ, Sack DA, Skwerer RG, Wehr TA: Seasonal affective disorder and its relevance for the understanding and treatment of bulimia; in Hudson JI, Pope HG (eds): The Psychology of Bulimia. Washington DC, American Psychiatric Press, 1987, pp 205-228.
- Danilenko KV, Ivanova IA: Dawn simulation vs. bright light in seasonal affective disorder: treatment effects and subjective preference. J Affect Disord 2015;180:87-89.
- Gillberg M, Kecklund G, Åkerstedt T: Relation between performance and subjective ratings of sleepiness during a night awake. Sleep 1994;17:236-241.
Williams JBW, Link MJ, Terman M: Self-rating version for the Hamilton Depression Rating Scale: Seasonal Affective Disorder Version (SIGH-SAD-SR). New York, New York State Psychiatric Institute, 1988.
- Canazei M, Pohl W, Bliem HR, Weiss EM: Acute effects of different light spectra on simulated night-shift work without circadian alignment. Chronobiol Int 2017;34:303-317.
- Clow A, Hucklebridge F, Thorn L: The cortisol awakening response in context. Int Rev Neurobiol 2010;93:153-175.
- Virk G, Reeves G, Rosenthal NE, Sher L, Postolache TT: Short exposure to light treatment improves depression scores in patients with seasonal affective disorder: a brief report. Int J Disabil Hum Dev 2009;8:283-286.
Article / Publication Details
Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.