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Clinical Practice: Mini-Review

Free Access

Renal Oxygenation and Hemodynamics in Kidney Injury

Bullen A. · Liu Z.Z. · Hepokoski M. · Li Y. · Singh P.

Author affiliations

Division of Nephrology-Hypertension, University of California, San Diego School of Medicine and VA San Diego Healthcare System, San Diego, CA, USA

Corresponding Author

Prof. Prabhleen Singh

Division of Nephrology-Hypertension

University of California San Diego and VA San Diego Healthcare System

3350 La Jolla Village Drive, 111-H, San Diego, CA 92161 (USA)

E-Mail p1singh@ucsd.edu

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Nephron 2017;137:260–263

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Abstract

Acute kidney injury (AKI) continues to be a major therapeutic challenge. Despite significant advances made in cellular and molecular pathophysiology of AKI, major gaps in knowledge exist regarding the changes in renal hemodynamics and oxygenation in the early stages and through the continuum of AKI. Particular features of renal hemodynamics and oxygenation increase the susceptibility of the kidney to sustain injury due to oxygen demand-supply mismatch and also play an important role in the recovery and repair from AKI as well as the transition of AKI to chronic kidney disease. However, lack of well-established physiological biomarkers and noninvasive imaging techniques limit our understanding of the interactions between renal macro and microcirculation and tissue oxygenation in AKI. Advances in our ability to assess these parameters in preclinical and clinical AKI will enable the development of targeted therapeutics to improve clinical outcomes.

© 2017 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Clinical Practice: Mini-Review

Received: May 22, 2017
Accepted: May 25, 2017
Published online: June 15, 2017
Issue release date: Published online first

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF


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