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Original Paper

Ganglion Cell-Inner Plexiform Layer Thickness in Different Glaucoma Stages Measured by Optical Coherence Tomography

Zivkovic M.a, b · Dayanir V.e · Zlatanovic M.a · Zlatanovic G.a, b · Jaksic V.c · Jovanovic P.a, b · Radenkovic M.a · Djordjevic-Jocic J.a, b · Stankovic-Babic G.a, b · Jovanovic S.d

Author affiliations

aOphthalmology Clinic, Clinical Center Niš, and bMedical Faculty, University of Niš, Niš, cMedical Faculty, University of Belgrade, Belgrade, dDepartment of Ophthalmology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; eBATIGOZ Health Group Eye Clinic, Izmir, Turkey

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 13, 2017
Accepted: June 04, 2017
Published online: September 07, 2017

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 3

ISSN: 0030-3747 (Print)
eISSN: 1423-0259 (Online)

For additional information: https://www.karger.com/ORE

Abstract

Aim: To compare ganglion cell (GCL) and inner plexiform layer (IPL) thickness in patients at different stages of primary open-angle glaucoma (POAG), determine their sensitivity and specificity values, and correlate thickness values with mean deviations (MD). Methods: This prospective, cross- sectional study was conducted in a group of patients with confirmed POAG who were compared to an age- and gender-matched control group. Glaucomatous damage was classified according to the Hodapp-Parrish-Anderson scale: glaucoma stage 1 (early), glaucoma stage 2 (moderate), and glaucoma stage 3 (severe). The average, minimum, and all 6 sectoral (superotemporal, superior, superonasal, inferonasal, inferior, and inferotemporal) GCL + IPL thicknesses were measured and compared between groups. Results: The average GCL + IPL thickness of 154 eyes of 93 patients in glaucoma stages 1, 2, 3, and 94 eyes of 47 persons in the control group were 76.79 ± 8.05, 65.90 ± 7.92, 57.38 ± 10.00, and 86.01 ± 3.68 μm, respectively. There were statistically significant differences in the average, minimum, and all 6 sectoral GCL + IPL values among the groups. The areas under the receiver operating characteristic curve for average and minimum GCL + IPL thickness values were 0.93 and 0.94, respectively, sensitivity 91.5 and 88.3%, and specificity 98.9 and 100%, respectively. Both thickness values showed significant correlations with MD. Each micrometer decrease in the average GCL + IPL thickness was associated with a 0.54-dB loss in MD. Conclusion: GCL + IPL layer thickness is a highly specific and sensitive parameter in differentiating glaucomatous from healthy eyes showing progressive damage as glaucoma worsens. Loss of this layer is highly correlated with overall loss of visual field sensitivity.

© 2017 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 13, 2017
Accepted: June 04, 2017
Published online: September 07, 2017

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 3

ISSN: 0030-3747 (Print)
eISSN: 1423-0259 (Online)

For additional information: https://www.karger.com/ORE


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