Login to MyKarger

New to MyKarger? Click here to sign up.

Login with Facebook

Forgot your password?

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login
(Shibboleth or Open Athens)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Clinical Practice: Mini-Review

Free Access

Lymphocyte Function in Human Acute Kidney Injury

Weller S. · Varrier M. · Ostermann M.

Author affiliations

Department of Critical Care, King's College London School of Medical Education, Guy's and St Thomas' NHS Foundation Trust, London, UK

Corresponding Author

Dr. Marlies Ostermann

Department of Critical Care, King's College London School of Medical Education

Guy's and St Thomas' NHS Foundation Trust

London SE1 7EH (UK)

E-Mail Marlies.Ostermann@gstt.nhs.uk

Related Articles for ""

Nephron 2017;137:287–293

Do you have an account?

Login Information

Contact Information

I have read the Karger Terms and Conditions and agree.


Acute kidney injury (AKI) has been recognised as an inflammatory condition with serious short- and long-term complications. Animal studies primarily using models of ischaemia reperfusion injury or caecal ligation and perforation have clearly demonstrated that inflammatory cells contribute to the initiation, propagation and recovery phase of AKI and that lymphocytes have a key role in these processes. Less is known about their involvement in common types of human AKI. This paper summarises the key findings of experimental AKI studies and limited human data with particular focus on the role of T-lymphocytes.

© 2017 S. Karger AG, Basel


  1. Jang HR, Rabb H: Immune cells in experimental acute kidney injury. Nat Rev Nephrol 2015;11:88-101.
  2. Gandolfo MT, Jang HR, Bagnasco SM, Ko GJ, Agreda P, Satpute SR, et al: Foxp3+ regulatory T cells participate in repair of ischemic acute kidney injury. Kidney Int 2009;76:717-729.
  3. Kinsey GR, Sharma R, Huang L, Li L, Vergis AL, Ye H, et al: Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury. J Am Soc Nephrol 2009;20:1744-1753.
  4. Martina MN, Noel S, Saxena A, Bandapalle S, Majithia R, Jie C, et al: Double-negative αβ T cells are early responders to AKI and are found in human kidney. J Am Soc Nephrol 2016;27:1113-1123.
  5. Burne MJ, Daniels F, El Ghandour A, Mauiyyedi S, Colvin RB, O'Donnell MP, et al: Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure. J Clin Invest 2001;108:1283-1290.
  6. Ascon DB, Lopez-Briones S, Liu M, Ascon M, Savransky V, Colvin RB, et al: Phenotypic and functional characterization of kidney-infiltrating lymphocytes in renal ischemia reperfusion injury. J Immunol 2006;177:3380-3387.
  7. Wang S, Diao H, Guan Q, Cruikshank WW, Delovitch TL, Jevnikar AM, et al: Decreased renal ischemia-reperfusion injury by IL-16 inactivation. Kidney Int 2008;73:318-326.
  8. Ascon DB, Ascon M, Satpute S, Lopez-Briones S, Racusen L, Colvin RB, et al: Normal mouse kidneys contain activated and CD3+CD4- CD8- double-negative T lymphocytes with a distinct TCR repertoire. J Leukoc Biol 2008;84:1400-1409.
  9. Burne-Taney MJ, Ascon DB, Daniels F, Racusen L, Baldwin W, Rabb H: B cell deficiency confers protection from renal ischemia reperfusion injury. J Immunol 2003;171:3210-3215.
  10. Ascon M, Ascon DB, Liu M, Cheadle C, Sarkar C, Racusen L, et al: Renal ischemia-reperfusion leads to long term infiltration of activated and effector-memory T lymphocytes. Kidney Int 2009;75:526-535.
  11. Jang HR, Gandolfo MT, Ko GJ, Satpute SR, Racusen L, Rabb H: B cells limit repair after ischemic acute kidney injury. J Am Soc Nephrol 2010;21:654-665.
  12. Day YJ, Huang L, Ye H, Linden J, Okusa MD: Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: role of macrophages. Am J Physiol Renal Physiol 2005;288:F722-F731.
  13. Lee SY, Lee YS, Choi HM, Ko YS, Lee HY, Jo SK, et al: Distinct pathophysiologic mechanisms of septic acute kidney injury: role of immune suppression and renal tubular cell apoptosis in murine model of septic acute kidney injury. Crit Care Med 2012;40:2997-3006.
  14. Hoffman W, Lakkis FG, Chalasani G: B cells, antibodies, and more. Clin J Am Soc Nephrol 2016;11:137-154.
  15. Lobo PI, Bajwa A, Schlegel KH, Vengal J, Lee SJ, Huang L, et al: Natural IgM anti-leukocyte autoantibodies attenuate excess inflammation mediated by innate and adaptive immune mechanisms involving Th-17. J Immunol 2012;188:1675-1685.
  16. Rosser EC, Mauri C: Regulatory B cells: origin, phenotype, and function. Immunity 2015;42:607-612.
  17. Kinsey GR, Okusa MD: Expanding role of T cells in acute kidney injury. Curr Opin Nephrol Hypertens 2014;23:9-16.
  18. Li L, Huang L, Sung SS, Lobo PI, Brown MG, Gregg RK, et al: NKT cell activation mediates neutrophil IFN-gamma production and renal ischemia-reperfusion injury. J Immunol 2007;178:5899-5911.
  19. Li L, Huang L, Vergis AL, Ye H, Bajwa A, Narayan V, et al: IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury. J Clin Invest 2010;120:331-342.
  20. Zhang ZX, Wang S, Huang X, Min WP, Sun H, Liu W, Garcia B, Jevnikar AM: NK cells induce apoptosis in tubular epithelial cells and contribute to renal ischemia-reperfusion injury. J Immunol 2008;181:7489-7498.
  21. Liu M, Chien CC, Burne-Taney M, Molls RR, Racusen LC, Colvin RB, Rabb H: A pathophysiologic role for T lymphocytes in murine acute cisplatin nephrotoxicity. J Am Soc Nephrol 2006;17:765-774.
  22. Krishnan N, Perazella MA: Drug-induced acute interstitial nephritis: pathology, pathogenesis, and treatment. Iran J Kidney Dis 2015;9:3-13.
  23. Wearne N, Swanepoel CR, Boulle A, Duffield MS, Rayner BL: The spectrum of renal histologies seen in HIV with outcomes, prognostic indicators and clinical correlations. Nephrol Dial Transplant 2012;27:4109-4118.
  24. Yung S, Chan TM: Mechanisms of kidney injury in lupus nephritis - the role of anti-dsDNA antibodies. Front Immunol 2015;6:475.
  25. Foster MH: T cells and B cells in lupus nephritis. Semin Nephrol 2007;27:47-58.
  26. Issa F, Schiopu A, Wood KJ: Role of T cells in graft rejection and transplantation tolerance. Expert Rev Clin Immunol 2010;6:155-169.
  27. Cho E, Lee JH, Lim HJ, Oh SW, Jo SK, Cho WY, et al: Soluble CD25 is increased in patients with sepsis-induced acute kidney injury. Nephrology (Carlton) 2014;19:318-324.
  28. Yang SH, Lee JP, Jang HR, Cha RH, Han SS, Jeon US, et al: Sulfatide-reactive natural killer T cells abrogate ischemia-reperfusion injury. J Am Soc Nephrol 2011;22:1305-1314.

Article / Publication Details

First-Page Preview
Abstract of Clinical Practice: Mini-Review

Received: April 18, 2017
Accepted: June 09, 2017
Published online: June 30, 2017
Issue release date: December 2017

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF

Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.