Variants in Chemosensory Genes Are Associated with Picky Eating Behavior in Preschool-Age ChildrenCole N.C.a · Wang A.A.a · Donovan S.M.a, b · Lee S.-Y.a, b · Teran-Garcia M.a,c,d · the STRONG Kids Team
aDivision of Nutritional Sciences, and Departments of bFood Science and Human Nutrition, and cHuman Development and Family Studies, and dCooperative Extension, University of Illinois, Urbana, IL, USA
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Article / Publication Details
Background/Aims: Picky eating is prevalent among preschoolers and is associated with risk of both underweight and overweight. Although differences in taste perception may be due to genetic variation, it is unclear whether these variations are related to picky eating behavior. The aim of this study was to investigate the association of 6 single nucleotide polymorphisms (SNPs) in 5 candidate genes related to chemosensory perception with picky eating behavior and adiposity in a cohort of preschool-aged children. Methods: Parents of 2- to 5-year-old non-Hispanic white preschoolers (n = 153) responded to survey questions on demographics, and information regarding their child's breastfeeding history and picky eating behavior. Height and weight were measured to calculate body mass index (BMI) z-scores using standard growth charts, and saliva was collected for genotyping. Generalized linear models were used to examine associations between picky eating behavior and BMI z-scores with genetic variation. Results: When controlling for child age, sex, breastfed status, and parent education level, SNPs in TAS2R38 (rs713598) and CA6 (rs2274327) were associated with picky eating behavior in children. There was no association between SNPs and BMI z-scores. Conclusion: Genes related to chemosensory perception may play a role in children's picky eating behavior.
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- van der Horst K, Deming DM, Lesniauskas R, Carr BT, Reidy KC: Picky eating: associations with child eating characteristics and food intake. Appetite 2016;103:286-293.
- Taylor CM, Wernimont SM, Northstone K, Emmett PM: Picky/fussy eating in children: review of definitions, assessment, prevalence and dietary intakes. Appetite 2015;95:349-359.
- Finistrella V, Manco M, Ferrara A, Rustico C, Presaghi F, Morino G: Cross-sectional exploration of maternal reports of food neophobia and pickiness in preschooler-mother dyads. J Am Coll Nutr 2012;31:152-159.
- Dubois L, Farmer A, Girard M, Peterson K, Tatone-Tokuda F: Problem eating behaviors related to social factors and body weight in preschool children: a longitudinal study. Int J Behav Nutr Phys Act 2007;4:9.
- Tharner A, Jansen PW, Kiefte-de Jong JC, Moll HA, Hofman A, Jaddoe VW, et al: Bidirectional associations between fussy eating and functional constipation in preschool children. J Pediatr 2015;166:91-96.
- Marchi M, Cohen P: Early childhood eating behaviors and adolescent eating disorders. J Am Acad Child Adolesc Psychiatry 1990;29:112-117.
- Zucker N, Copeland W, Franz L, Carpenter K, Keeling L, Angold A, et al: Psychological and psychosocial impairment in preschoolers with selective eating. Pediatrics 2015;136:e582-e590.
- Machado BC, Dias P, Lima VS, Campos J, Gonçalves S: Prevalence and correlates of picky eating in preschool-aged children: a population-based study. Eat Behav 2016;22:16-21.
- Jacobi C, Schmitz G, Agras WS: Is picky eating an eating disorder? Int J Eat Disord 2008;41:626-634.
- Boquin M, Smith-Simpson S, Donovan SM, Lee SY: Mealtime behaviors and food consumption of perceived picky and nonpicky eaters through home use test. J Food Sci 2014;79:S2523-S2532.
- Carruth BR, Skinner J, Houck K, Moran J, Coletta F, Ott D: The phenomenon of “picky eater”: a behavioral marker in eating patterns of toddlers. J Am Coll Nutr 1998;17:180-186.
- Jacobi C, Agras WS, Bryson S, Hammer LD: Behavioral validation, precursors, and concomitants of picky eating in childhood. J Am Acad Child Adolesc Psychiatry 2003;42:76-84.
- Galloway AT, Fiorito L, Lee Y, Birch LL: Parental pressure, dietary patterns, and weight status among girls who are “picky eaters.” J Am Diet Assoc 2005;105:541-548.
- Tharner A, Jansen PW, Kiefte-de Jong JC, Moll HA, van der Ende J, Jaddoe VW, et al: Toward an operative diagnosis of fussy/picky eating: a latent profile approach in a population-based cohort. Int J Behav Nutr Phys Act 2014;11:14.
- Galloway AT, Lee Y, Birch LL: Predictors and consequences of food neophobia and pickiness in young girls. J Am Diet Assoc 2003;103:692-698.
- Cardona Cano S, Tiemeier H, Van Hoeken D, Tharner A, Jaddoe VW V, Hofman A, et al: Trajectories of picky eating during childhood: a general population study. Int J Eat Disord 2015;48:570-579.
- Cooke LJ, Haworth CM, Wardle J: Genetic and environmental influences on children's food neophobia. Am J Clin Nutr 2007;86:428-433.
- Faith MS, Heo M, Keller KL, Pietrobelli A: Child food neophobia is heritable, associated with less compliant eating, and moderates familial resemblance for BMI. Obesity (Silver Spring) 2013;21:1650-1655.
- Smith AD, Herle M, Fildes A, Cooke L, Steinsbekk S, Llewellyn CH: Food fussiness and food neophobia share a common etiology in early childhood. J Child Psychol Psychiatry 2017;58:189-196.
- Birch LL: Development of food preferences. Annu Rev Nutr 1999;19:41-62.
- Drewnowski A: Taste preferences and food intake. Annu Rev Nutr 1997;17:237-253.
- Keller KL, Steinmann L, Nurse RJ, Tepper BJ: Genetic taste sensitivity to 6-n-propylthiouracil influences food preference and reported intake in preschool children. Appetite 2002;38:3-12.
- Mennella JA, Pepino MY, Reed DR: Genetic and environmental determinants of bitter perception and sweet preferences. Pediatrics 2005;115:e216-e222.
- Turnbull B, Matisoo-Smith E: Taste sensitivity to 6-n-propylthiouracil predicts acceptance of bitter-tasting spinach in 3- to 6-year-old children. Am J Clin Nutr 2002;76:1101-1105.
- O'Brien SA, Feeney EL, Scannell AGM, Markey A, Gibney ER: Bitter taste perception and dietary intake patterns in Irish children. J Nutrigenet Nutrigenomics 2013;6:43-58.
- Dias AG, Eny KM, Cockburn M, Chiu W, Nielsen DE, Duizer L, et al: Variation in the TAS1R2 gene, sweet taste perception and intake of sugars. J Nutrigenet Nutrigenomics 2015;8:81-90.
- Padiglia A, Zonza A, Atzori E, Chillotti C, Calò C, Tepper BJ, et al: Sensitivity to 6-n-propylthiouracil is associated with gustin (carbonic anhydrase VI) gene polymorphism, salivary zinc, and body mass index in humans. Am J Clin Nutr 2010;92:539-545.
- Hayes JE, Feeney EL, Nolden AA, McGeary JE: Quinine bitterness and grapefruit liking associate with allelic variants in TAS2R31. Chem Senses 2015;40:437-443.
- Cole TJ, Faith MS, Pietrobelli A, Heo M: What is the best measure of adiposity change in growing children: BMI, BMI %, BMI z-score or BMI centile? Eur J Clin Nutr 2005;59:419-425.
- Harrison K, Bost KK, McBride BA, Donovan SM, Grigsby-Toussaint DS, Kim J, et al: Toward a developmental conceptualization of contributors to overweight and obesity in childhood: the six-Cs model. Child Dev Perspect 2011;5:50-58.
- Lewinsohn PM, Holm-Denoma JM, Gau JM, Joiner TE, Striegel-Moore R, Bear P, et al: Problematic eating and feeding behaviors of 36-month-old children. Int J Eat Disord 2005;38:208-219.
- Kuczmarski RJ, Ogden CL, Guo SS, Grummer-Strawn LM, Flegal KM, Mei Z, et al: 2000 CDC growth charts for the United States: methods and development. Vital Health Stat 11 2002;246:1-190.
- Calò C, Padiglia A, Zonza A, Corrias L, Contu P, Tepper BJ, et al: Polymorphisms in TAS2R38 and the taste bud trophic factor, gustin gene co-operate in modulating PROP taste phenotype. Physiol Behav 2011;104:1065-1071.
- Hayes JE, Feeney EL, Allen AL: Do polymorphisms in chemosensory genes matter for human ingestive behavior? Food Qual Prefer 2013;30:202-216.
- Pirastu N, Robino A, Lanzara C, Athanasakis E, Esposito L, Tepper BJ, et al: Genetics of food preferences: a first view from silk road populations. J Food Sci 2012;77:S413-S438.
- Bouthoorn SH, van Lenthe FJ, Kiefte-de Jong JC, Taal HR, Wijtzes AI, Hofman A, et al: Genetic taste blindness to bitter and body composition in childhood: a Mendelian randomization design. Int J Obes 2013;38:1-6.
- Bell KI, Tepper BJ: Short-term vegetable intake by young children classified by 6-n-propylthoiuracil bitter-taste phenotype. Am J Clin Nutr 2006;84:245-251.
- Rodenburg G, Kremers SPJ, Oenema A, van de Mheen D: Associations of children's appetitive traits with weight and dietary behaviours in the context of general parenting. PLoS One 2012;7:e50642.
- Lumeng JC, Cardinal TM, Sitto JR, Kannan S: Ability to taste 6-n-propylthiouracil and BMI in low-income preschool-aged children. Obesity (Silver Spring) 2008;16:1522-1528.
- Keller KL, Tepper BJ: Inherited taste sensitivity to 6-n-propylthiouracil in diet and body weight in children. Obes Res 2004;12:904-912.
- Bufe B, Breslin PAS, Kuhn C, Reed DR, Tharp CD, Slack JP, et al: The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr Biol 2005;15:322-327.
- Keller KL, Adise S: Variation in the ability to taste bitter thiourea compounds: implications for food acceptance, dietary intake, and obesity risk in children. Annu Rev Nutr 2016;36:157-182.
- Kim U, Jorgenson E, Coon H, Leppert M, Risch N, Drayna D, et al: Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science 2003;299:1221-1225.
- Bartoshuk LM, Duffy VB, Miller IJ: PTC/PROP tasting: anatomy, psychophysics, and sex effects. Physiol Behav 1994;56:1165-1171.
- Feeney E, O'Brien S, Scannell A, Markey A, Gibney ER: Genetic variation in taste perception: does it have a role in healthy eating? Proc Nutr Soc 2011;70:135-143.
- Shatzman AR, Henkin RI: Gustin concentration changes relative to salivary zinc and taste in humans. Proc Natl Acad Sci USA 1981;78:3867-3871.
- Essick GK, Chopra A, Guest S, McGlone F: Lingual tactile acuity, taste perception, and the density and diameter of fungiform papillae in female subjects. Physiol Behav 2003;80:289-302.
- Melis M, Atzori E, Cabras S, Zonza A, Calò C, Muroni P, et al: The Gustin (CA6) gene polymorphism, rs2274333 (A/G), as a mechanistic link between PROP tasting and fungiform taste papilla density and maintenance. PLoS One 2013;8:e74151.
- Barbarossa IT, Melis M, Mattes MZ, Calò C, Muroni P, Crnjar R, et al: The gustin (CA6) gene polymorphism, rs2274333 (A/G), is associated with fungiform papilla density, whereas PROP bitterness is mostly due to TAS2R38 in an ethnically-mixed population. Physiol Behav 2015;138:6-12.
- Peres RCR, Camargo G, Mofatto LS, Cortellazzi KL, Santos MCLG, Santos MN, et al: Association of polymorphisms in the Carbonic Anhydrase 6 gene with salivary buffer capacity, dental plaque pH, and caries index in children aged 7-9 years. Pharmacogenomics J 2010;10:114-119.
- Aidar M, Marques MR, Valjakka J, Mononen N, Lehtimäki T, Parkkila S, et al: Effect of genetic polymorphisms in Ca6 gene on the expression and catalytic activity of human salivary carbonic anhydrase VI. Caries Res 2013;47:414-420.
- Farrow CV, Coulthard H: Relationships between sensory sensitivity, anxiety and selective eating in children. Appetite 2012;58:842-846.
- Boquin MM, Moskowitz HR, Donovan SM, Lee SY: Defining perceptions of picky eating obtained through focus groups and conjoint analysis. J Sens Stud 2014;29:126-138.
- Monnery-Patris S, Wagner S, Rigal N, Schwartz C, Chabanet C, Issanchou S, et al: Smell differential reactivity, but not taste differential reactivity, is related to food neophobia in toddlers. Appetite 2015;95:303-309.
- Addessi E, Galloway AT, Visalberghi E, Birch LL: Specific social influences on the acceptance of novel foods in 2-5-year-old children. Appetite 2005;45:264-271.
- Werthmann J, Jansen A, Havermans R, Nederkoorn C, Kremers S, Roefs A: Bits and pieces. Food texture influences food acceptance in young children. Appetite 2015;84:181-187.
- Coulthard H, Harris G, Emmett P: Delayed introduction of lumpy foods to children during the complementary feeding period affects child's food acceptance and feeding at 7 years of age. Matern Child Nutr 2009;5:75-85.
- Coulthard H, Thakker D: Enjoyment of tactile play is associated with lower food neophobia in preschool children. J Acad Nutr Diet 2015;115:1134-1140.
- Nederkoorn C, Jansen A, Havermans RC: Feel your food. The influence of tactile sensitivity on picky eating in children. Appetite 2015;84:7-10.
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