Sleep and Olfaction among Older AdultsMcSorley V.E.a · Pinto J.b · Schumm L.P.a · Wroblewski K.a · Kern D.d · McClintock M.c · Lauderdale D.S.a
aDepartment of Public Health Sciences, bPritzker School of Medicine, and cDepartment of Psychology, University of Chicago, and dNortheastern Illinois University, College of Arts and Sciences, Chicago, IL, USA
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Article / Publication Details
Background: Sleep and olfaction are both critical physiological processes that tend to worsen with age. Decline in olfaction can be an early indicator of neurodegenerative diseases, whereas poor sleep quality is associated with reduced physical and mental health. Given associations with aging-related health declines, we explored whether variations in sleep were associated with olfactory function among older adults. Methods: We assessed the relationship between sleep characteristics and olfaction among 354 community-dwelling older adults. Olfaction was measured using a validated field and survey research tool. Sleep characteristics were measured using wrist actigraphy and with self-report of sleep problems. We fit structural equation models of latent constructs of olfaction based on olfactory task items and let this be a function of each sleep characteristic. Results: Actigraph sleep quality measures were associated with odor identification, but not with odor sensitivity. Longer duration sleepers had worse odor sensitivity compared to medium (58 h) sleepers, but sleep duration was not associated with odor identification. Reported sleep problems and reported usual duration were not associated with olfaction. Conclusions: Diminished sleep quality was associated with reduced capacity to identify odors. Determining whether this is a causal association will require further study and longitudinal data.
© 2017 S. Karger AG, Basel
- Doucet S, Soussignan R, Sagot P, Schaal B: The secretion of Areolar (Montgomery's) glands from lactating women elicits selective, unconditional responses in neonates. PLoS One 2009;4:e7579.
- Jacob S, Garcia S, Hayreh D, McClintock MK: Psychological effects of musky compounds: comparison of androstadienone with androstenol and muscone. Horm Behav 2002;42:274-283.
- Patel RM, Pinto JM: Olfaction: anatomy, physiology, and disease. Clini Anat 2014;27:54-60.
Kim WY, Hur M, Cho MS, Lee HS: Effect of olfactory function on nutritional status of Korean elderly women. Nutr Res 2003;23:723-734.
- Toussaint N, de Roon M, van Campen JP, Kremer S, Boesveldt S: Loss of olfactory function and nutritional status in vital older adults and geriatric patients. Chem Senses 2015;40:197-203.
- Boesveldt S, Lindau ST, McClintock MK, Hummel T, Lundström JN: Gustatory and olfactory dysfunction in older adults: a national probability study. Rhinology 2011;49:324-330.
- Sivam A, Wroblewski KE, Alkorta-Aranburu G, Barnes LL, Wilson RS, Bennett DA, Pinto JM: Olfactory dysfunction in older adults is associated with feelings of depression and loneliness. Chem Senses 2016;41:293-299.
- Keller A, Malaspina D: Hidden consequences of olfactory dysfunction: a patient report series. BMC Ear Nose Throat Disord 2013;13:8.
- Pinto JM, Wroblewski KE, Kern DW, Schumm LP, Mcclintock MK: The rate of age-related olfactory decline among the general population of older U.S. adults. J Gerontol A Biol Sci Med Sci 2015;70:1435-1441.
- Doty RL, Reyes PF, Gregor T: Presence of both odor identification and detection deficits in Alzheimer's disease. Brain Res Bull 1987;18:597-600.
- Attems J, Walker L, Jellinger KA: Olfaction and aging: a mini-review. Gerontology 2015;61:485-490.
- Wilson RS, Yu L, Bennett DA: Odor identification and mortality in old age. Chem Senses 2011;36:63-67.
- Pinto JM, Schumm LP, Wroblewski KE, Kern DW, Mcclintock MK: Racial disparities in olfactory loss among older adults in the United States. J Gerontol A Biol Sci Med Sci 2014;69:323-329.
- Devanand DP, Lee S, Manly J, Andrews H, Schupf N, Masurkar A, Stern Y, Mayeux R, Doty RL: Olfactory identification deficits and increased mortality in the community. Ann Neurol 2015;78:401-411.
- Schubert CR, Fischer ME, Pinto AA, Klein BEK, Klein R, Tweed TS, Cruickshanks KJ: Sensory impairments and risk of mortality in older adults. J Gerontol A Biol Sci Med Sci 2017;72:710-715.
- Hoffman HJ, Rawal S, Li CM, Duffy VB: New chemosensory component in the U.S. National Health and Nutrition Examination Survey (NHANES): first-year results for measured olfactory dysfunction. Rev Endocr Metab Disord 2016;17:221-240.
- Murphy C, Schubert CR, Cruickshanks KJ, Klein BE, Klein R, Nondahl DM: Prevalence of olfactory impairment in older adults. JAMA 2002;288:2307-2312.
- Schubert CR, Cruickshanks KJ, Dalton DS, Klein BE, Klein R, Nondahl DM: Prevalence of sleep problems and quality of life in an older population. Sleep 2002;25:889-893.
- Floyd JA, Medler SM, Ager JW, Janisse JJ: Age-related changes in initiation and maintenance of sleep: a meta-analysis. Res Nurs Health 2000;23:106-117.
- Ohayon MM, Carskadon MA, Guilleminault C, Vitiello MV: Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan. Sleep 2004:27;255-273.
- Kurina LM, McClintock MK, Chen JH, Waite LJ, Thisted RA, Lauderdale DS: Sleep duration and all-cause mortality: a critical review of measurement and associations. Ann Epidemiol 2013;23:361-370.
- Rod NH, Vahtera J, Westerlund H, Kivimaki M, Zins M, Goldberg M, Lange T: Sleep disturbances and cause-specific mortality: results from the GAZEL cohort study. Am J Epidemiol 2011;173:300-309.
An C, Yu L, Wang L, Jin G, Song M, Zhu Q, Jia H, Liu K, Wang M, Wang X: Association between sleep characteristics and mild cognitive impairment in elderly people. Neurophysiology 2014;46:88-94.
- Spira AP, Chen-Edinboro LP, Wu MN, Yaffe K: Impact of sleep on the risk of cognitive decline and dementia. Curr Opin Psychiatry 2014;27:478-483.
- Blackwell T, Yaffe K, Ancoli-Israel S, Schneider JL, Cauley JA, Hillier TA, Fink HA, Stone KL: Poor sleep is associated with impaired cognitive function in older women: the study of osteoporotic fractures. J Gerontol A Biol Sci Med Sci 2006;61:405-410.
- Knutson KL, Van Cauter E, Rathouz PJ, Yan LL, Hulley SB, Liu K, Lauderdale D: Association between sleep and blood pressure in midlife: the CARDIA Sleep Study. Arch Intern Med 2009;169:1055-1061.
- Prehn-Kristensen A, Lotzkat K, Bauhofer E, Wiesner CD, Baving L: Sleep supports memory of odors in adults but not in children. PLoS One 2015;10:1-14.
- Barnes DC, Wilson DA: Slow-wave sleep-imposed replay modulates both strength and precision of memory. J Neurosci 2014;34:5134-5142.
- Badia P, Wesensten N, Lammers W, Culpepper J, Harsh J: Responsiveness to olfactory stimuli presented in sleep. Physiol Behav 1990;48:89-90.
- Stuck BA, Stieber K, Frey S, Freiburg C, Hörmann K, Maurer JT, Hummel T: Arousal responses to olfactory or trigeminal stimulation during sleep. Sleep 2007;30:506-510.
Rasch B, Sutton J: About sleep's role in memory. Psychologist 2014;27:320-323.
- Rasch B, Büchel C, Gais S, Born J: Odor cues during slow-wave sleep prompt declarative memory consolidation. Science 2007;315:1426-1429.
- Diekelmann S, Biggel S, Rasch B, Born J: Offline consolidation of memory varies with time in slow wave sleep and can be accelerated by cuing memory reactivations. Neurobiol Learn Mem 2012:98;103-111.
- Diekelmann S, Büchel C, Born J, Rasch B: Labile or stable: opposing consequences for memory when reactivated during waking and sleep. Nat Neurosci 2011;17:74-76.
- Killgore WD, McBride SA: Odor identification accuracy declines following 24 h of sleep deprivation. J Sleep Res 2006;15:111-116.
Thomas ML, Sing HC, Belenky G, Holcomb HH, Mayberg HS, Dannals RF, Wagner HN, Thorne DR, Popp KA, Rowland LM, Welsh AB, Balwinski SM, Redmond DP: Neural basis of alertness and cognitive performance impairments during sleepiness II: effects of 48 and 72 h of sleep deprivation on waking human regional brain activity. Thalamus Relat Syst 2003;2:199-229.
- O'Doherty K, Jaszczak A, Hoffmann JN, You HM, Kern DW, Pagel K, McPhillips J, Schumm LP, Dale W, Huang ES, Mcclintock MK: Survey field methods for expanded biospecimen and biomeasure collection in NSHAP Wave 2. J Gerontol B Phychol Sci Soc Sci 2014;69:S27-S37.
- Kern DW, Wroblewski KE, Schumm LP, Pinto JM, Mcclintock MK: Field survey measures of olfaction: the Olfactory Function Field Exam (OFFE). Field methods 2014;26:421-434.
- Mueller C, Renner B: A new procedure for the short screening of olfactory function using five items from the “Sniffin' Sticks” identification test kit. Am J Rhinol 2006;20:113-116.
- Kern DW, Schumm LP, Wroblewski KE, Pinto JM, Hummel T, McClintock MK: Olfactory thresholds of the U.S. population of home-dwelling older adults: development and validation of a short, reliable measure. PLoS One 2015;10:e0118589.
- Pinto JM, Kern DW, Wroblewski KE, Chen RC, Schumm LP, Mcclintock MK: Sensory function: insights from wave 2 of the National Social Life, Health, and Aging Project. J Gerontol B Psychol Sci Soc Sci 2014;69:144-153.
- Lauderdale DS, Schumm LP, Kurina LM, McClintock M, Thisted RA, Chen JH, Waite L: Assessment of sleep in the National Social Life, Health, and Aging Project. J Gerontol B Phychol Sci Soc Sci 2014;69(suppl 2):S125-S133.
- Chen JH, Waite L, Kurina LM, Thisted RA, Mcclintock MK, Lauderdale D: Insomnia symptoms and actigraph-estimated sleep characteristics in a nationally representative sample of older adults. J Gerontol A Biol Sci Med Sci 2015;70:185-192.
- Nasreddine ZS, Phillips NA, Bedirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL, Chertkow H: The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 2005;53:695-659.
- Shega JW, Sunkara PD, Kotwal A, Kern DW, Henning SL, Mcclintock MK, Schumm P, Waite LJ, Dale W: Measuring cognition: the Chicago cognitive function measure in the national social life, health and aging project, wave 2. J Gerontol B Psychol Sci Soc Sci 2014;69(suppl 2)S166-S176.
- Kotwal AA, Schumm P, Kern DW, Mcclintock MK, Waite LJ, Shega JW, Huisingh-Scheetz MJ, Dale W: Evaluation of a brief survey instrument for assessing subtle differences in cognitive function among older adults. Alzheimer Dis Assoc Disord 201529:317-324.
- Charlson ME, Pompei P, Ales KL, MacKenzie CR: A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987;40:373-383.
- Vasilopoulos T, Kotwal AA, Huisingh-Scheetz MJ, Waite LJ, Mcclintock MK, Dale W: Comorbidity and chronic conditions in the national social life, health and aging project (NSHAP), wave 2. J Gerontol B Psychol Sci Soc Sci 2014;69(suppl 2):S154-S165.
- Cappuccio FP, D'Elia L, Strazzullo P, Miller MA: Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies. Sleep 2010;33:585-592.
- Baron RM, Kenny DA: The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol 1986;51:1173-1182.
- O'Muircheartaigh C, English N, Pedlow S, Kwok PK: Sample design, sample augmentation, and estimation for Wave 2 of the NSHAP. J Gerontol B Psychol Sci Soc Sci 2014;69(suppl 2):S15-S26.
- Ramos AR, Tarraf W, Daviglus M, Davis S, Gallo LC, Mossavar-Rahmani Y, Penedo FJ, Redline S, Rundek T, Sacco RL, Sotres-Alvarez D, Wright CB, Zee PC, Gonzalez HM: Sleep duration and neurocognitive function in the Hispanic Community Health Study/Study of Latinos. Sleep 2016;39:1843-1851.
- Ancoli-Israel S, Cole R, Alessi C, Chambers M, Moorcroft W, Pollak CP: The role of actigraphy in the study of sleep and circadian rhythms. Sleep 2003;26:342-392.
- Kern DW, Wroblewski KE, Schumm LP, Pinto JM, Chen RC, McClintock MK: Olfactory function in wave 2 of the national social life, health, and aging project. J Gerontol B Psychol Sci Soc Sci 2014;69(suppl 2):S134-S143.
- Blackwell T, Yaffe K, Ancoli-Israel S, Redline S, Ensrud KE, Stefanick ML, Laffan A, Stone KL: Association of sleep characteristics and cognition in older community-dwelling men: the MrOS sleep study. Sleep 2011;34:1347-1356.
- Devanand DP, Tabert MH, Cuasay K, Manly JJ, Schupf N, Brickman AM, Andrews H, Brown TR, DeCarli C, Mayeux R: Olfactory identification deficits and MCI in a multi-ethnic elderly community sample. Neurobiol Aging 2010;31:1593-1600.
- Swan GE, Carmelli D: Impaired olfaction predicts cognitive decline in nondemented older adults. Neuroepidemiology 2002;21:58-67.
- Folstein MF, Folstein SE, McHugh PR: “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
- Coen RF, Robertson DA, Kenny RA, King-Kallimanis BL: Strengths and limitations of the MoCA for assessing cognitive functioning: findings from a large representative sample of Irish older adults. J Geriatr Psychiatry Neur 2016;29:18-24.
- Wilson RS, Arnold SE, Tang Y, Bennett DA: Odor identification and decline in different cognitive domains in old age. Neuroepidemiology 2006;26:61-67.
- Barnes DC, Wilson DA: Sleep and olfactory cortical plasticity. Front Behav Neurosci 2015;8:134.
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