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Original Paper

Downregulation of Striatal Dopamine D2 Receptors in Advanced Parkinson’s Disease Contributes to the Development of Motor Fluctuation

Hwang W.-J.a · Yao W.-J.b · Wey S.-P.c · Shen L.-H.c · Ting G.c

Author affiliations

Departments of aNeurology, bNuclear Medicine, College of Medicine, National Cheng Kung University, Tainan, and cInstitute of Nuclear Energy Research, Lung-Tan, Taiwan

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Eur Neurol 2002;47:113–117

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: February 15, 2002
Issue release date: February 2002

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: https://www.karger.com/ENE

Abstract

The purpose of this study was to evaluate the contribution of the postsynaptic mechanism to the development of motor fluctuation in advanced Parkinson’s disease (PD). We used 123I-iodobenzamide single-photon emission computed tomography to measure the striatal dopamine D2 receptor densities in early levodopa-naïve PD, chronic PD with stable levodopa response, and advanced PD with fluctuating levodopa response. The basal ganglia/frontal cortex ratios at both hemispheres were calculated and averaged. PD patients with fluctuating levodopa response showed a significant decrease in striatal dopamine D2 receptor densities compared to those with early (1.57 ± 0.20 vs. 1.77 ± 0.12, p = 0.009) or chronic stable PD (1.57 ± 0.20 vs. 1.77 ± 0.10, p = 0.024). We conclude that the decreased D2 receptor densities in advanced PD reduced the ‘safety factor’ for synaptic transmission and contributed to the development of motor fluctuation.

© 2002 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: February 15, 2002
Issue release date: February 2002

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: https://www.karger.com/ENE


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