Login to MyKarger

New to MyKarger? Click here to sign up.



Login with Facebook

Forgot your password?

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login
(Shibboleth or Open Athens)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Review

Trans-Fatty Acids and Cardiovascular Disease: Urgent Need for Legislation

Wilczek M.M.a · Olszewski R.b · Krupienicz A.c

Author affiliations

aMedical Faculty, Poznan University of Medical Sciences, Poznan, bDepartment of Ultrasound, Institute of Fundamental Technological Research, Polish Academy of Sciences, and cDepartment of Basic Nursing, Medical University of Warsaw, Warsaw, Poland

Related Articles for ""

Cardiology 2017;138:254-258

Do you have an account?

Login Information





Contact Information










I have read the Karger Terms and Conditions and agree.



Login Information





Contact Information










I have read the Karger Terms and Conditions and agree.



To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!

If you would like to redeem your KAB credit, please log in.


Save over 20% compared to the individual article price.
Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00


Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Review

Received: June 21, 2017
Accepted: August 03, 2017
Published online: September 26, 2017
Issue release date: Published online first

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: https://www.karger.com/CRD

Abstract

Hydrogenated oils containing trans-fatty acids (TFA) are used to produce margarine and various processed foods. TFA affect serum lipid levels, fatty acid metabolism, and endothelial function. High TFA intake is linked to increased all-cause mortality, coronary heart disease mortality, and cardiovascular disease (CVD) incidence. Denmark was the first country to introduce a law that limited TFA content in food; this action led to lower CVD mortality. So far 7 European countries have followed this practice, in a few others the food industry voluntarily reduced TFA use. The issue remains mostly unaddressed in the rest of the world. Legal TFA limits should be commonly established as they are the optimal solution considering both CVD prevention and the associated cost savings in public healthcare.

© 2017 S. Karger AG, Basel


References

  1. Willett W, Mozaffarian D: Ruminant or industrial sources of trans fatty acids: public health issue or food label skirmish? Am J Clin Nutr 2008;87:515-516.
    External Resources
  2. Brouwer IA, Wanders AJ, Katan MB: Trans fatty acids and cardiovascular health: research completed? Eur J Clin Nutr 2013;67:541-547.
  3. Dawczynski C, Lorkowski S: Trans-fatty acids and cardiovascular risk: does origin matter? Expert Rev Cardiovasc Ther 2016;14:1001-1005.
  4. Micha R, Khatibzadeh S, Shi P, Fahimi S, Lim S, Andrews KG, et al: Global, regional, and national consumption levels of dietary fats and oils in 1990 and 2010: a systematic analysis including 266 country-specific nutrition surveys. BMJ 2014;348:g2272.
  5. Pappalardo JK, Ringold DJ: Regulating commercial speech in a dynamic environment: forty years of margarine and oil advertising before the NLEA. J Public Policy Mark 2000;19:74-92.
    External Resources
  6. Willett WC, Stampfer MJ, Manson JE, Colditz GA, Speizer FE, Rosner BA, et al: Intake of trans fatty acids and risk of coronary heart disease among women. Lancet 1993;341:581-585.
  7. Downs SM, Thow AM, Leeder SR: The effectiveness of policies for reducing dietary trans fat: a systematic review of the evidence. Bull World Health Organ 2013;91:262h-269h.
  8. Mozaffarian D, Katan MB, Ascherio A, Stampfer MJ, Willett WC: Trans fatty acids and cardiovascular disease. N Engl J Med 2006;354:1601-1613.
  9. Mensink RP, Zock PL, Kester AD, Katan MB: Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr 2003;77:1146-1155.
    External Resources
  10. de Roos NM, Bots ML, Katan MB: Replacement of dietary saturated fatty acids by trans fatty acids lowers serum HDL cholesterol and impairs endothelial function in healthy men and women. Arterioscler Thromb Vasc Biol 2001;21:1233-1237.
  11. Baer DJ, Judd JT, Clevidence BA, Tracy RP: Dietary fatty acids affect plasma markers of inflammation in healthy men fed controlled diets: a randomized crossover study. Am J Clin Nutr 2004;79:969-973.
    External Resources
  12. Valenzuela A, Morgado N: Trans fatty acid isomers in human health and in the food industry. Biol Res 1999;32:273-287.
    External Resources
  13. Ginter E, Simko V: New data on harmful effects of trans-fatty acids. Bratisl Lek Listy 2016;117:251-253.
    External Resources
  14. de Souza RJ, Mente A, Maroleanu A, Cozma AI, Ha V, Kishibe T, et al: Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies. BMJ 2015;351:h3978.
  15. Sun Q, Ma J, Campos H, Hankinson SE, Manson JE, Stampfer MJ, et al: A prospective study of trans fatty acids in erythrocytes and risk of coronary heart disease. Circulation 2007;115:1858-1865.
  16. Lemaitre RN, King IB, Raghunathan TE, Pearce RM, Weinmann S, Knopp RH, et al: Cell membrane trans-fatty acids and the risk of primary cardiac arrest. Circulation 2002;105:697-701.
  17. Piepoli MF, Hoes AW, Agewall S, Albus C, Brotons C, Catapano AL, et al: 2016 European guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J 2016;37:2315-2381.
  18. Eckel RH, Jakicic JM, Ard JD, de Jesus JM, Miller NH, Hubbard VS, et al: 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk. Circulation 2014;129:S76-S99.
  19. Anderson TJ, Grégoire J, Hegele RA, Couture P, Mancini GBJ, McPherson R, et al: 2012 update of the Canadian Cardiovascular Society guidelines for the diagnosis and treatment of dyslipidemia for the prevention of cardiovascular disease in the adult. Can J Cardiol 2013;29:151-167.
  20. Herdy A, López-Jiménez F, Terzic C, Milani M, Stein R, Carvalho T, et al: South American guidelines for cardiovascular disease prevention and rehabilitation. Arq Bras Cardiol 2014;103:1-31.
    External Resources
  21. Leth T, Jensen HG, Mikkelsen AA, Bysted A: The effect of the regulation on trans fatty acid content in Danish food. Atheroscler Suppl 2006;7:53-56.
  22. Restrepo BJ, Rieger M: Denmark's policy on artificial trans fat and cardiovascular disease. Am J Prev Med 2016;50:69-76.
  23. Stender S, Dyerberg J, Astrup A: Consumer protection through a legislative ban on industrially produced trans fatty acids in foods in Denmark. Food Nutr Res 2006;50:155-160.
    External Resources
  24. Stender S, Astrup A, Dyerberg J: Artificial trans fat in popular foods in 2012 and in 2014: a market basket investigation in six European countries. BMJ Open 2016;6:e010673.
  25. Stender S, Astrup A, Dyerberg J: Tracing artificial trans fat in popular foods in Europe: a market basket investigation. BMJ Open 2014;4:e005218.
  26. Restrepo BJ, Rieger M: Trans fat and cardiovascular disease mortality: evidence from bans in restaurants in New York. J Health Econ 2016;45:176-196.
  27. US Department of Health and Human Services, Food and Drug Administration: Final determination regarding partially hydrogenated oils. Federal Register, 2015. https://www.federalregister.gov/d/2015-14883 (accessed December 7, 2016).
  28. Stender S, Astrup A, Dyerberg J: A trans European Union difference in the decline in trans fatty acids in popular foods: a market basket investigation. BMJ Open 2012;2: e000859.
  29. Żbikowska A, Krygier K: Changes in the fatty acids composition, especially trans isomers, and heat stability of selected frying fats available on the Polish market in the years 1997 and 2008. Pol J Food Nutr Sci 2011;61:45-49.
    External Resources
  30. Stender S, Dyerberg J, Bysted A, Leth T, Astrup A: A trans world journey. Atheroscler Suppl 2006;7:47-52.
  31. WHO Regional Committee for Europe: European food and nutrition action plan 2015-2020. 2014. http://www.euro.who.int/en/publications/abstracts/european-food-and-nutrition-action-plan-20152020 (accessed December 10, 2016).
  32. European Society of Cardiology, European Association for Cardiovascular Prevention and Rehabilitation: Position paper on industrial trans fatty acids. 2014. http://www.escardio.org/static_file/Escardio/EU-Affairs/esc-position-paper-on-tfa.pdf (accessed January 2, 2017).
  33. European Parliament: European Parliament resolution of 26 October 2016 on trans fats (TFAs). 2016. http://www.europarl.europa.eu/sides/getDoc.do?pubRef=-//EP//TEXT +TA+P8-TA-2016-0417+0+DOC+XML+ V0//EN (accessed December 22, 2016).
  34. Nielsen K: Is the quality and cost of food affected if industrially produced trans fatty acids are removed? Atheroscler Suppl 2006;7:61-62.
  35. Martin-Saborido C, Mouratidou T, Livaniou A, Caldeira S, Wollgast J: Public health economic evaluation of different European Union-level policy options aimed at reducing population dietary trans fat intake. Am J Clin Nutr 2016;104:1218-1226.
  36. Jasti S, Kovacs S: Use of trans fat information on food labels and its determinants in a multiethnic college student population. J Nutr Educ Behav 2010;42:307-314.
  37. World Health Organization: Global status report on road safety 2015. http://www.who.int/violence_injury_prevention/road_safety_status/2015/en/ (accessed July 23, 2017).

Article / Publication Details

First-Page Preview
Abstract of Review

Received: June 21, 2017
Accepted: August 03, 2017
Published online: September 26, 2017
Issue release date: Published online first

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: https://www.karger.com/CRD


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.