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Original Article

Successful Evidence-Based Treatment of Patients with Advanced Pancreatic Cancer in Community-Based Oncology Group Practices

Chakupurakal G.a · Feiten S.b · Burkhard O.c · Reiser M.d · Ehscheidt P.e · Weide R.a

Author affiliations

aPraxisklinik für Hämatologie und Onkologie, Koblenz, Germany; bInstitut für Versorgungsforschung in der Onkologie, Koblenz, Germany; cInternistische Gemeinschaftspraxis Hämatologie, Onkologie, Palliativmedizin, Worms, Germany; dpioh - Praxis Internistischer Onkologie und Hämatologie, Cologne, Germany; ePraxis für Hämatologie und Onkologie, Neuwied, Germany

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Oncol Res Treat 2017;40:784-788

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: May 09, 2017
Accepted: August 04, 2017
Published online: November 29, 2017
Issue release date: December 2017

Number of Print Pages: 5
Number of Figures: 4
Number of Tables: 1

ISSN: 2296-5270 (Print)
eISSN: 2296-5262 (Online)

For additional information: https://www.karger.com/ORT

Abstract

Background: Randomized clinical trials do not reflect the day-to-day reality of patient care; hence, the treatment of patients with advanced pancreatic cancer in oncology group practices was evaluated. Patients and Methods: All consecutive patients with advanced pancreatic cancer who were treated between 01/2012 and 12/2015 in 4 oncology group practices were analyzed retrospectively using SPSS software. Results: 324 patients with a median age of 70 years (range 32-94 years) were analyzed. The majority were male (56%) and had distant metastases (74%). Chemotherapy was the major modality of treatment (86%) with a median overall survival (OS) of 33.3 weeks (range 1.7-245.4 weeks). Chemotherapy significantly (p < 0.001) improved OS in comparison to best supportive care only (37.6 vs. 13.9 weeks). Patients with locally advanced disease had a better prognosis compared to patients with metastases (median OS 49.6 vs. 30.4 weeks; p < 0.001). An age-adjusted Charlson comorbidity score of ≥ 9 was found to influence the OS significantly (p = 0.004). Conclusion: Chemotherapy remains the main modality of treatment for patients with advanced pancreatic cancer with an OS comparable to prospective randomized trials. The OS of this patient cohort has remained the same over the last 20 years despite advances in treatment modalities.

© 2017 S. Karger GmbH, Freiburg


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Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: May 09, 2017
Accepted: August 04, 2017
Published online: November 29, 2017
Issue release date: December 2017

Number of Print Pages: 5
Number of Figures: 4
Number of Tables: 1

ISSN: 2296-5270 (Print)
eISSN: 2296-5262 (Online)

For additional information: https://www.karger.com/ORT


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