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Original Paper

Open Access Gateway

Impact of a pH 5 Oil-in-Water Emulsion on Skin Surface pH

Fürtjes T.a · Weiss K.T.a · Filbry A.b · Rippke F.b · Schreml S.a

Author affiliations

aDepartment of Dermatology, University Medical Center Regensburg, Regensburg, and bBeiersdorf AG, Hamburg, Germany

Corresponding Author

Stephan Schreml, MD

Department of Dermatology, University Medical Center Regensburg

Franz-Josef-Strauss-Allee 11

DE-93053 Regensburg (Germany)

E-Mail stephan@schreml.de

Related Articles for ""

Skin Pharmacol Physiol 2017;30:292-297

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Abstract

Background: Human skin surface has a physiologically acidic pH (pHss). In cases of increased pHss, the acidity of the skin can be restored by topical formulations. We tested a pH 5 oil-in-water (O/W) emulsion for pHss regeneration and stabilization. Methods: We performed 2 experiments with 10 female study subjects in each. In both experiments, 2D imaging with luminescent sensor foils was used to determine pHss. Alkalization was reached by washing the volar forearm with a soap bar and warm running tap water for 20 min. Experiment 1: after defining the baseline pHss, we alkalized the respective area and measured pHss over a duration of 5 h, while applying emulsion every hour. Experiment 2: study subjects used the emulsion twice daily for 1 week. Then, pHss was measured before and after 5 min of washing a treated and an untreated area on the volar forearm. Results: (1) 5 h after alkalization, the treated arm showed a significantly lower pHss than the untreated one (5.87 ± 0.03 vs. 6.05 ± 0.03); (2) after washing, the treated area had a significantly lower pHss than controls (6.13 ± 0.03 vs. 6.27 ± 0.05). Conclusions: The tested pH 5 O/W emulsion seems to improve regeneration and stabilization of pHss.

© 2017 The Author(s) Published by S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 14, 2017
Accepted: August 13, 2017
Published online: October 04, 2017
Issue release date: Published online first

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: https://www.karger.com/SPP


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