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Short Communication

Hypoxic Stress Upregulates the Expression of Slc38a1 in Brown Adipocytes via Hypoxia-Inducible Factor-1α

Horie T.a · Fukasawa K.a · Iezaki T.a, b · Park G.a · Onishi Y.a · Ozaki K.a · Kanayama T.a · Hiraiwa M.a · Kitaguchi Y.a · Kaneda K.a · Hinoi E.a

Author affiliations

aLaboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, and bVenture Business Laboratory, Organization of Frontier Science and Innovation, Kanazawa University, Kanazawa, Japan

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Pharmacology 2018;101:64-71

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Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: July 18, 2017
Accepted: August 17, 2017
Published online: October 25, 2017
Issue release date: Published online first (Issue-in-Progress)

Number of Print Pages: 8
Number of Figures: 6
Number of Tables: 1

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA

Abstract

The availability of amino acid in the brown adipose tissue (BAT) has been shown to be altered under various conditions; however, little is known about the possible expression and pivotal role of amino acid transporters in BAT under physiological and pathological conditions. The present study comprehensively investigated whether amino acid transporters are regulated by obesogenic conditions in BAT in vivo. Moreover, we investigated the mechanism underlying the regulation of the expression of amino acid transporters by various stressors in brown adipocytes in vitro. The expression of solute carrier family 38 member 1 (Slc38a1; gene encoding sodium-coupled neutral amino acid transporter 1) was preferentially upregulated in the BAT of both genetic and acquired obesity mice in vivo. Moreover, the expression of Slc38a1 was induced by hypoxic stress through hypoxia-inducible factor-1α, which is a master transcription factor of the adaptive response to hypoxic stress, in brown adipocytes in vitro. These results indicate that Slc38a1 is an obesity-associated gene in BAT and a hypoxia-responsive gene in brown adipocytes.

© 2017 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: July 18, 2017
Accepted: August 17, 2017
Published online: October 25, 2017
Issue release date: Published online first (Issue-in-Progress)

Number of Print Pages: 8
Number of Figures: 6
Number of Tables: 1

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA


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