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Original Paper

Capsaicin Used on Skin Influences Ion Transport Pathways: An in vitro Study

Hołyńska-Iwan I.a · Dziembowska I.b · Smyk P.a · Lampka M.a · Olszewska-Słonina D.a

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Departments of aPathobiochemistry and Clinical Chemistry and bPathophysiology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Torun, Bydgoszcz, Poland

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Skin Pharmacol Physiol 2018;31:19-27

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 25, 2017
Accepted: September 15, 2017
Published online: November 08, 2017
Issue release date: Published online first (Issue-in-Progress)

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 1

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: https://www.karger.com/SPP

Abstract

Acute, adverse skin effects to capsaicin can be activated by inhibition of sodium transport not only in nociceptive neurons, but also in keratinocytes. The aim of the current study was to describe and compare immediate (15 s) and prolonged (30 min) effects of capsaicin on epidermal (not neural) sodium transport using a rabbit skin model. Skin fragments (n = 169) were incubated in 4 conditions: undisturbed ion transport (U; n = 48); inhibited sodium transport (INa; n = 34) with amiloride used as sodium transport blocker; long-term irritation by capsaicin with undisturbed ion transport (CAPSA-U; n = 43) and with inhibited sodium transport (CAPSA-INa; n = 35). After 30 min of incubation, a solution of capsaicin was applied directly to the skin fragments. The study demonstrated that sodium transport inhibition eliminated the effects of both immediate and prolonged capsaicin application. The results could be the basis for future research considering selective sodium transport inhibitors for human skin to reduce the side effects of capsaicin, related to activation of sodium channels in keratinocytes.

© 2017 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 25, 2017
Accepted: September 15, 2017
Published online: November 08, 2017
Issue release date: Published online first (Issue-in-Progress)

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 1

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: https://www.karger.com/SPP


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