Annals of Nutrition and Metabolism

Original Paper

Serum Transaminase Concentrations and the Presence of Irritable Bowel Syndrome Are Associated with Serum 25-Hydroxy Vitamin D Concentrations in Adolescent Girls Who Are Overweight and Obese

Khayyatzadeh S.S.a · Vatanparast H.b · Avan A.c,d · Bagherniya M.a · Bahrami A.d · Kiani M.A.e · Bahrami-Taghanaki H.f · Ferns G.A.g · Ghayour-Mobarhan M.c,d

Author affiliations

aStudent Research Committee, Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
bCollege of Pharmacy and Nutrition, University of Saskatchewan, Health Sciences E-Wing, Saskatoon, SK, Canada
cMetabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
dDepartment of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
ePediatric Gastroenterologist, Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
fChinese and Complementary Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
gBrighton and Sussex Medical School, Division of Medical Education, Brighton, United Kingdom

Keywords: Vitamin DBody mass indexLiver functional testIrritable bowel syndromeObesity

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Ann Nutr Metab 2017;71:234–241
https://doi.org/10.1159/000484634

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 02, 2017
Accepted: October 24, 2017
Published online: November 14, 2017
Issue release date: January 2018

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 5

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: https://www.karger.com/ANM

Abstract

Background/Aims: Vitamin D deficiency has become endemic globally and its etiology is complex. Few studies have investigated the determinants of serum 25-hydroxy vitamin D (25-OH D). The aim of this study was to investigate the association between lifestyle patterns, liver functional tests (LFTs), and the presence of irritable bowel syndrome (IBS) with serum 25-OH D in apparently healthy girls. Methods: This cross-sectional study was undertaken in 965 adolescent girls aged 12–18 years. IBS was diagnosed using the Rome III questionnaire. An electrochemiluminescence method was used to measure serum 25-OH D. LFTs were measured using commercial kits and an auto analyzer. Linear regression and univariate analyses were performed to determine the association between continuous and categorical variables with serum 25-OH D respectively. Results: Serum 25-OH D was significantly higher in normal weight subjects compared to either overweight or obese subjects (9.5 ± 7.02 vs. 7.9 ± 5.7 ng/mL, p = 0.03). Physical activity level was positively associated with serum 25-OH D in overweight and obese subjects (β = 0.15, p < 0.05). An inverse relationship was found between the presence of IBS and 25-OH D in both normal (β = –1.95, p < 0.05), overweight and obese subjects (β = –1.83, p < 0.05). Serum alanine transaminase (ALT; β = –0.19, p < 0.05) and aspartate transaminase (β = –0.17, p < 0.05) were inversely associated with serum 25-OH in overweight and obese subjects. Conclusions: Individuals with IBS had significantly lower serum 25-OH D concentrations. In addition, there was an inverse association between serum ALT and 25-OH D. Prospective studies, and perhaps interventional trials, will be required to clarify these associations.

© 2017 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 02, 2017
Accepted: October 24, 2017
Published online: November 14, 2017
Issue release date: January 2018

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 5

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: https://www.karger.com/ANM

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