Neonatology

Novel Insights from Clinical Practice

Is There More to Zika? Complex Cardiac Disease in a Case of Congenital Zika Syndrome

Angelidou A.a, b · Michael Z.b, c · Hotz A.b, d · Friedman K.b, e · Emani S.b, f · LaRovere K.b, g · Christou H.a-c

Author affiliations

aDivision of Newborn Medicine, Boston Children's Hospital, bHarvard Medical School, cDepartment of Pediatric Newborn Medicine, Brigham and Women's Hospital, and Departments of dMedicine, eCardiology, fCardiovascular Surgery, and gNeurology, Boston Children's Hospital, Boston, MA, USA

Keywords: Hypoplastic left heart syndromeMicrocephalyPolymicrogyriaStaged palliationTropism

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Neonatology 2018;113:177–182
https://doi.org/10.1159/000484656

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Article / Publication Details

First-Page Preview
Abstract of Novel Insights from Clinical Practice

Received: September 22, 2017
Accepted: October 27, 2017
Published online: December 16, 2017
Issue release date: February 2018

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 0

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

Abstract

The epidemic of Zika virus (ZIKV) has resulted in a surge of newborns with microcephaly and brain abnormalities. In this report, we describe the first case, to our knowledge, of congenital Zika syndrome with concomitant critical congenital heart disease. The mother had a confirmed ZIKV infection in the first trimester of pregnancy. Fetal ultrasonography at 31 weeks of gestation revealed cerebral cortical calcifications and hypoplastic left heart syndrome. The severity of brain involvement was assessed by postnatal magnetic resonance imaging and echocardiogram, and palliative surgery was performed. The ethical dimensions of this infant's clinical management are discussed. ZIKV is known to affect neural progenitor cells, but whether it could have a tropism for other tissues remains unclear.

© 2017 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Novel Insights from Clinical Practice

Received: September 22, 2017
Accepted: October 27, 2017
Published online: December 16, 2017
Issue release date: February 2018

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 0

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

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2018, Vol.113, No. 2

February 2018

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A.A. and Z.M. contributed equally to this work.
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