Annals of Nutrition and Metabolism
Original Paper
Ghrelin is Negatively Correlated with Iron in the Serum in Human and MiceLuo Q.-Q.a · Zhou G.b · Huang S.-N.a · Mu M.D.c · Chen Y.-J.a · Qian Z.-M.aaDepartment of Pharmacology and Laboratory of Prevention and Treatment of Neurodegenerative Diseases, Department of Biochemistry, Nantong University Medical School, Nantong, China
bDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China cSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China |
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Ann Nutr Metab 2018;72:37–42
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Article / Publication Details
First-Page Preview
Received: June 27, 2017
Accepted: October 26, 2017
Published online: December 14, 2017
Issue release date: February 2018
Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 0
ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)
For additional information: https://www.karger.com/ANM
Abstract
Background/Aims: The studies in the patients with iron deficiency anemia (IDA) implied the existence of the association of ghrelin with iron or hepcidin levels in the plasma under the pathophysiological conditions. We hypothesized that fasting may be able to affect iron metabolism via ghrelin under the physiological conditions. Methods: We investigated the effects of fasting on serum ghrelin and iron contents in healthy volunteers (23–31 years) and C57BL/6 male mice (8-week-olds) under the physiological conditions. Results: Fasting induced a significant elevation in both total ghrelin and acylated ghrelin and a reduction in iron levels in the serum of both human and mice. Correlation analysis demonstrated that total ghrelin or acylated ghrelin is negatively correlated with iron in the serum in human and mice. Conclusion: Ghrelin has a role to reduce serum iron under the conditions of fasting.
© 2017 S. Karger AG, Basel
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References
- Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K: Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402: 656–660.
- Gutierrez JA, Solenberg PJ, Perkins DR, Willency JA, Knierman MD, Jin Z, Witcher DR, Luo S, Onyia JE, Hale JE: Ghrelin octanoylation mediated by an orphan lipid transferase. Proc Natl Acad Sci U S A 2008; 105: 6320–6325.
- Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL: Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 2008; 132: 387–396.
- Tschöp M, Smiley DL, Heiman ML: Ghrelin induces adiposity in rodents. Nature 2000; 407: 908–913.
- Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S: A role for ghrelin in the central regulation of feeding. Nature 2001; 409: 194–198.
- Cowley MA, Smith RG, Diano S, Tschöp M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P, Low MJ, Sotonyi P, Friedman JM, Liu H, Pinto S, Colmers WF, Cone RD, Horvath TL: The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 2003; 37: 649–661.
- Müller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D’Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Diéguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrère B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschöp MH: Ghrelin. Mol Metab 2015; 4: 437–460.
- Steinert RE, Feinle-Bisset C, Asarian L, Horowitz M, Beglinger C, Geary N: Ghrelin, CCK, GLP-1, and PYY(3–36): secretory controls and physiological roles in eating and glycemia in health, obesity, and after RYGB. Physiol Rev 2017: 97: 411–463.
- Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR: Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 2001; 86: 5992.
- Cummings DE, Frayo RS, Marmonier C, Aubert R, Chapelot D: Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues. Am J Physiol Endocrinol Metabol 2004; 287:E297–E304.
- Natalucci G, Riedl S, Gleiss A, Zidek T, Frisch H: Spontaneous 24-h ghrelin secretion pattern in fasting subjects: maintenance of a meal-related pattern. Eur J Endocrinol 2005; 152: 845–850.
- Dogan A, Alioglu B, Dindar N, Dallar Y: Increased serum hepcidin and ghrelin levels in children treated for iron deficiency anemia. J Clin Lab Anal 2013; 27: 81–85.
- Luke B: Nutrition and multiple gestation. Semin Perinatol 2005; 29: 349–354.
- Akarsu S, Ustundag B, Gurgoze MK, Sen Y, Aygun AD: Plasma ghrelin levels in various stages of development of iron deficiency anemia. J Pediatr Hematol Oncol 2007; 29: 384–387.
- Isguven P, Arslanoglu I, Erol M, Yildiz M, Adal E, Erguven M: Serum levels of ghrelin, leptin, IGF-I, IGFBP-3, insulin, thyroid hormones and cortisol in prepubertal children with iron deficiency. Endocr J 2007; 54: 985–990.
- Krause A, Neitz S, Mägert HJ, Schulz A, Forssmann WG, Schulz-Knappe P, Adermann K: LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett 2000; 480: 147–150.
- Park CH, Valore EV, Waring AJ, Ganz T: Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001; 276: 7806–7810.
- Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loréal O: A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 2001; 276: 7811–7819.
- Nicolas G, Bennoun M, Devaux I, Beaumont C, Grandchamp B, Kahn A, Vaulont S: Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci U S A 2001; 98: 8780–8785.
- Ganz T: Systemic iron homeostasis. Physiol Rev 2013; 93: 1721–1741.
- Poli M, Asperti M, Ruzzenenti P, Regoni M, Arosio P: Hepcidin antagonists for potential treatments of disorders with hepcidin excess. Front Pharmacol 2014; 5: 86.
- Qian ZM, Xiao DS, Ke Y, Liao QK: Increased nitric oxide is one of the causes of changes of iron metabolism in strenuously exercised rats. Am J Physiol Regul Integr Comp Physiol 2001; 280:R739–R743.
- Xiao DS, Ho KP, Qian ZM: Nitric oxide inhibition decreases bleomycin-detectable iron in spleen, bone marrow cells and heart but not in liver in exercise rats. Mol Cell Biochem 2004; 260: 31–37.
- Qian ZM, Xiao DS, Tang PL, Yao FY, Liao QK: Increased expression of transferrin receptor on membrane of erythroblasts in strenuously exercised rats. J Appl Physiol 1999; 87: 523–529.
- Ke Y, Chen YY, Chang YZ, Duan XL, Ho KP, Jiang DH, Wang K, Qian ZM: Post -transcriptional expression of DMT1 in the heart of rat. J Cell Physiol 2003: 196: 124–130.
- Liu Y, Wu XM, Luo QQ, Huang S, Yang QW, Wang FX, Ke Y, Qian ZM: CX3CL1/CX3CR1-mediated microglia activation plays a detrimental role in ischemic mice brain via p38MAPK/PKC pathway. J Cereb Blood Flow Metab 2015; 35: 1623–1631.
- Xiao DS, Qian ZM: Plasma nitric oxide and iron concentrations in exercised rats are negatively correlated. Mol Cell Biochem 2000; 208: 163–166.
- Li Z, Lai Z, Ya K, Fang D, Ho YW, Lei Y, Ming QZ: Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-induciblefactor-1 in hypoxic HepG2 cells. J Cell Mol Med 2008: 12: 569–579.
- Kilic N, Aydin S, Barim AO: Hormonal alterations in prepubertal children with iron deficiency. Endocr J 2009; 56: 309.
- Mihalache L, Gherasim A, Nita O, Ungureanu MC, Padureanu SS, Gavril RS, Arhire LI: Effects of ghrelin in energy balance and body weight homeostasis. Hormones 2016; 15: 186–196.
- Nogueiras R, Tovar S, Mitchell SE, Rayner DV, Archer ZA, Dieguez C, Williams LM: Regulation of growth hormone secretagogue receptor gene expression in the arcuate nuclei of the rat by leptin and ghrelin. Diabetes 2004; 53: 2552–2558.
- Aguilera A, Cirugeda A, Amair R, Sansone G, Alegre L, Codoceo R, Bajo MA, del Peso G, Díez JJ, Sánchez-Tomero JA, Selgas R: Ghrelin plasma levels and appetite in peritoneal dialysis patients. Adv Perit Dial 2004; 20: 194–199.
- Kalra SP, Ueno N, Kalra PS: Stimulation of appetite by ghrelin is regulated by leptin restraint: peripheral and central sites of action. J Nutr 2005; 135: 1331–1335.
- Chung B, Matak P, McKie AT, Sharp P: Leptin increases the expression of the iron regulatory hormone hepcidin in HuH7 human hepatoma cells. J Nutr 2007; 137: 2366–2370.
- Gao Y, Li Z, Gabrielsen JS, Simcox JA, Lee SH, Jones D, Cooksey B, Stoddard G, Cefalu WT, McClain DA: Adipocyte iron regulates leptin and food intake. J Clin Invest 2015; 125: 3681–3691.
Article / Publication Details
First-Page Preview
Received: June 27, 2017
Accepted: October 26, 2017
Published online: December 14, 2017
Issue release date: February 2018
Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 0
ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)
For additional information: https://www.karger.com/ANM
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