Cells Tissues Organs

Original Paper

Responsiveness of Infrapatellar Fat Pad Volume Change to Body Weight Loss or Gain: Data from the Osteoarthritis Initiative

Steidle-Kloc E. · Dannhauer T. · Wirth W. · Eckstein F.

Author affiliations

Institute of Anatomy, Paracelsus Medical University Salzburg and Nuremberg, Salzburg, Austria

Keywords: Body mass indexHoffa’s fat padKneeOsteoarthritis InitiativeMagnetic resonance imaging

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Cells Tissues Organs 2018;205:53–62
https://doi.org/10.1159/000485833

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: November 25, 2017
Published online: February 01, 2018
Issue release date: April 2018

Number of Print Pages: 10
Number of Figures: 4
Number of Tables: 1

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: https://www.karger.com/CTO

Abstract

Obesity is a potent risk factor for knee osteoarthritis (OA) that is driven by mechanical and potentially endocrine mechanisms, and it affects women more frequently than men. The infrapatellar fat pat (IPFP) represents a potential link between obesity, intra-articular inflammation and structural pathology. Here we investigate whether the IPFP is responsive to body weight loss/gain in women and how its responsiveness to weight change compares to that of subcutaneous fat (SCF) of the thigh. All female participants of the Osteoarthritis Initiative (OAI) with ≥10% weight loss/gain between baseline and a 2-year follow-up were included. Within-subject changes in IPFP volume and SCF cross-sectional areas (CSA) were determined from 3-T magnetic resonance imaging. Linear regression was used to assess the association between change in weight, IPFP volume, and SCF CSA. In the 38 participants with ≥10% weight loss over 2 years (age 59.3 ± 9.1 years, mean loss = 15.9%), there was a significant reduction in IPFP volume (-2.2%, p = 0.02) as well as in SCF CSA (-22%, p < 0.001). In the 34 participants with ≥10% gain (age 61.5 ± 8.7 years, mean gain = 15.9%), there was a significant increase in SCF CSA (+26%, p < 0.001) but not in IPFP volume (0.2%, p = 0.87). Weight change was significantly associated with SCF CSA change (r = 0.76, p < 0.001) but not with IPFP volume change (r = 0.11, p = 0.37). In this first longitudinal, observational study investigating the responsiveness of IPFP and SCF to weight change, IPFP morphology was found responsive to weight loss but not to weight gain. Overall, the responsiveness of the IPFP was substantially less than that of the SCF.

© 2018 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: November 25, 2017
Published online: February 01, 2018
Issue release date: April 2018

Number of Print Pages: 10
Number of Figures: 4
Number of Tables: 1

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: https://www.karger.com/CTO

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2018, Vol.205, No. 1

April 2018

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Clinical trial registration: registry name: Osteoarthritis Initiative (OAI): A Knee Health Study; registration identifier: NCT00080171; IRB approval No. 10-00532.
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