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Pharmacopsychiatry. Main Editor: B. Saletu (Vienna) / Original Paper

Effect of Chronic Repetitive Transcranial Magnetic Stimulation on Regional Cerebral Blood Flow and Regional Cerebral Glucose Uptake in Drug Treatment-Resistant Depressives

A Brief Report

Conca A.a · Peschina W.b · König P.a · Fritzsche H.b · Hausmann A.c

Author affiliations

aDepartment of Psychiatry I, Regional Hospital of Rankweil, bDepartment of Nuclear Medicine, Hospital of Feldkirch, cDepartment of Psychiatry, University Clinic of Innsbruck, Austria

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Neuropsychobiology 2002;45:27–31

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Article / Publication Details

First-Page Preview
Abstract of Pharmacopsychiatry. Main Editor: B. Saletu (Vienna)  /  Original Paper

Published online: January 10, 2002
Issue release date: January 2002

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS

Abstract

Brain imaging studies have shown that repetitive transcranial magnetic stimulation (rTMS) is biologically active. The aim of the present study was to investigate the patterns of the regional cerebral glucose uptake rate (rCMRGlu) and regional 99mTc HMPAO uptake rate (regional cerebral blood flow; rCBF) during a series of therapeutic rTMS sessions at low frequency. Four drug-resistant depressed patients underwent 10 rTMS sessions as an add-on measure over 14 days. One day before and 1 day after the TMS series, 511-keV SPECT with simultaneous 18F-fluorodeoxyglucose and 99mTc HMPAO measurements were carried out. All patients showed a good clinical outcome. Statistically significant common changes in rCBF and rCMRGlu patterns were found in the upper frontal regions bilaterally in terms of increased uptake rates and in the left orbitofrontal cortex in terms of decreased uptake rates of both isotopes compared to controls. However, the lateralization patterns of rCBF and rCMRGlu after rTMS treatment revealed marked differences. Thus, although no relevant changes in lateralization of the glucose uptake were observed, a clear right-sided preponderance of rCBF also in areas remote from the stimulation site was described. Therapeutic rTMS seems to influence distinct cortical regions, affecting rCBF and rCMRGlu in a homogeneous manner as well as in different ways, which are probably region dependent and illness related. The role of the stimulation coil placement site should be taken into account.

© 2002 S. Karger AG, Basel


References

  1. George MS, Lisanby SH, Sackeim HA: Transcranial magnetic stimulation. Application in neuropsychiatry. Arch Gen Psychiatry 1999;56:300–311.
  2. Kimbrell TA, Little JT, Dunn RT, Frye M, Greenberg BD, Wassermann EM, Repella JD, Danielson AL, Willis MW, Benson BE, Speer AM, Osuch E, George MS, Post RM: Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism. Biol Psychiatry 1999;46:1603–1613.
  3. Stallings LE, Speer AM, Spicer KM, Cheng KT, George MS: Combining SPECT and repetitive transcranial magnetic stimulation (rTMS)-left prefrontal stimulation decreases relative perfusion locally in a dose-dependent manner (abstract). Neuroimage 1997;5:521.
  4. George MS, Wassermann EM, Williams WA, Callahan A, Ketter TA, Basser P, Hallett M, Post RM: Daily repetitive transcranial magnetic stimulation (rTMS) improves mood in depression. Neuroreport 1995;6:1853–1856.
    External Resources
  5. Teneback C, Nahas Z, Speer AM, Molloy M, Stallings LE, Spicer KM, Risch SC, George MS: Changes in prefrontal cortex and paralimbic activity in depression following two weeks of daily left prefrontal TMS. J Neuropsychiatry Clin Neurosci 1999;11:426–435.
  6. Wu JC, Gillin C, Buchbaum MS, Hershey T, Johnson C, Bunney WE Jr: Effect of sleep deprivation on brain metabolism of depressed patients. Am J Psychiatry 1992;149:538–543.
  7. Nobler MS, Sackeim HS, Prohovnik I, Moeller JR, Mukherjee S, Schnur DB, Prudic J, Devanand DP: Regional cerebral blood flow in mood disorders, III. Treatment and clinical response. Arch Gen Psychiatry 1994;51:884–897.
  8. Buchsbaum MS, Wu J, Siegel MV, Hackett E, Trenary M, Abel L, Reynolds C: Effect of sertraline on regional metabolic rate in patients with affective disorder. Biol Psychiatry 1997;41:15–22.
  9. Kumar A: PET in mood disorders; in Krishnan KRR, Doraiswamy PM (eds): Brain Imaging in Clinical Psychiatry. New York, Dekker, 1997, pp 215–236.
  10. Conca A, Koppi S, König P, Swoboda E, Krecke N: Transcranial magnetic stimulation: A novel antidepressive strategy? Neuropsychobiology 1996;34:204–207.
    External Resources
  11. Herscovitch P: Radiotracer technique for functional neuroimaging with positron emission tomography; in Thatcher RW, Hallet M, Zeffiro T, Roy John E, Huerta M (eds): Functional Neuroimaging: Technical Foundations. San Diego, Academic, 1994, pp 29–46.
  12. Magistretti PJ, Pellerin L, Martin JL: Brain energy metabolism. An integrated cellular perspective; in Bloom FE, Kupfer DJ (eds): Psychopharmacology: The Fourth Generation of Progress. New York, Raven, 1995, pp 657–670.
  13. Thase ME, Rush HA: Treatment resistant depression; in Bloom FE, Kupfer DJ (eds): Psychopharmacology: The Fourth Generation of Progress. New York, Raven, 1995, pp 1081–1098.
  14. Beric A: Transcranial electrical and magnetic stimulation; in Devinsky O, Beric A, Dogali M (eds): Electrical and Magnetic Stimulation of the Brain and Spinal Cord. New York, Raven, 1993, pp 29–42.
  15. Schaefer A, Oberhausen E: Performance of a Multispect 2 gamma camera for imaging 511-keV gamma rays (in German). Nuklearmedizin 1995;34:40–46.
  16. Haas C, Hillbrand E, Hoch T, Fritzsche H: 18-FDG single photon computed tomography in heart and brain scintigraphy: Instrumentation and physical aspects; in Bergmann H, Kroiss A, Sinzinger H (eds): Proceedings of the 22nd International Badgastein Symposium in Radioactive Isotopes in Clinical Medicine and Research. Basel, Birkhäuser, 1997, pp 213–217.
  17. Sachs L: Angewandte Statistik, ed 7. Berlin, Springer, 1992.
  18. Fox P, Ingham R, George MS, Mayberg H, Ingham J, Roby J, Martin C, Jerabek P: Imaging human intra-cerebral connectivity by PET during TMS. Neuroreport 1997;8:2787–2791.
    External Resources

Article / Publication Details

First-Page Preview
Abstract of Pharmacopsychiatry. Main Editor: B. Saletu (Vienna)  /  Original Paper

Published online: January 10, 2002
Issue release date: January 2002

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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