Cytogenetic and Genome Research

Original Article

An International Genetic Survey of Breed-Specific Diseases in Working Dogs from the United States, Israel, and Poland

Shaffer L.G.a, b · Ramirez C.J.a · Phelps P.c, d · Aviram M.e · Walczak M.e, f · Bar-Gal G.K.e · Ballif B.C.a

Author affiliations

aPaw Print Genetics, Genetic Veterinary Sciences, Inc., Spokane, WA, bSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA, cSmithsonian Museum of Natural History, Washington, DC, and dJHM Professional Development and Career Office, Johns Hopkins University School of Medicine, Baltimore, MD, USA; eThe Koret School of Veterinary Medicine, The Robert H Smith Faculty of Agriculture, Food and Environment, Hebrew University of Jerusalem, Jerusalem, Israel; fDepartment of Animal Behavior, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Magdalenka, Poland

Keywords: Inherited disease testingLaw enforcementService dogsWorking dogsDegenerative myelopathyGenetic diseaseGenetic testing

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Cytogenet Genome Res 2017;153:198-204
https://doi.org/10.1159/000486774

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Accepted: November 09, 2017
Published online: February 09, 2018
Issue release date: April 2018

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 5

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR

Abstract

Genetic diseases occur in breeds used for law enforcement. As important team members, dogs are expected to operate at peak performance for several years and are significant investments for both the initial purchase and extensive, specialized training. Previous studies have not focused on causes for retirement or euthanasia as genetic (inherited) versus acquired (environmental). We performed direct mutational analysis for breed-specific conditions on samples from 304 dogs including 267 law enforcement (122 US, 87 Israeli, and 58 Polish) and 37 search and rescue dogs. Genetic testing identified 29% (n = 89) of the dogs tested to be carriers of a genetic mutation and 6% (n = 19) to be at risk for a debilitating inherited condition that may eventually impair the dog's ability to work. At-risk dogs included Labrador Retrievers (n = 4) with exercise-induced collapse, Bloodhounds (n = 2) with degenerative myelopathy (DM), and German Shepherd dogs with DM (n = 12) or leukocyte adhesion deficiency, type III (n = 1). A substantial number of working dogs were shown to be at risk for genetic conditions that may shorten the dog's career. The loss of dogs, due to early retirement or euthanasia, as a result of preventable genetic conditions has an emotional cost to handlers and financial cost to service organizations that can be avoided with genetic screening prior to breeding, buying, or training.

© 2018 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Article

Accepted: November 09, 2017
Published online: February 09, 2018
Issue release date: April 2018

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 5

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR

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2017, Vol.153, No. 4

April 2018

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