Nephron

Clinical Practice: Original Paper

The Relationship between Carotid and Femoral Artery Intima-Media Thickness and Histopathologic Grade of Atherosclerosis in Patients with Chronic Kidney Disease

Nezami N.a,b · Ghabili K.c · Shokouhi-Gogani B.d · Mirchi M.e · Ghojazadeh M.f · Safa J.g · Zomorrodi A.h · Gharadaghi A.i · Mojadidi M.K.j · Tarzamni M.K.f · Khajir G.k · Ghorashi S.l · Revzin M.a

Author affiliations

aDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA
bDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
cDepartment of Urology, Yale University School of Medicine, New Haven, CT, USA
dDepartment of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran
eDepartment of Radiology, Tabriz University of Medical Sciences, Tabriz, Iran
fLiver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
gDepartment of Nephrology, Tabriz University of Medical Sciences, Tabriz, Iran
hDepartment of Transplantation, Tabriz University of Medical Sciences, Tabriz, Iran
iDepartment of Surgery, Tabriz University of Medical Sciences, Tabriz, Iran
jDivision of Cardiology, University of Florida, Gainesville, FL, USA
kTuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
lSouthern Connecticut State University, New Haven, CT, USA

Keywords: AtherosclerosisIntima media thicknessCommon carotid arteryFemoral arteryHistopathologyChronic kidney disease

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Nephron 2018;139:159–169
https://doi.org/10.1159/000487491

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Article / Publication Details

First-Page Preview
Abstract of Clinical Practice: Original Paper

Received: November 01, 2017
Accepted: February 03, 2018
Published online: March 07, 2018
Issue release date: May 2018

Number of Print Pages: 11
Number of Figures: 3
Number of Tables: 3

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF

Abstract

Background/Aims: Variability in the grade of atherosclerosis among patients with chronic kidney disease (CKD) could affect the ultrasound measurements of intima media thickness (IMT). We sought to investigate IMTs of carotid (cIMT) and femoral (fIMT) arteries in CKD patients and assess the degree of their correlation with histopathological atherosclerosis. Methods: Eighty-nine out of 99 enrolled subjects completed this study. The subjects were divided into 3 groups: 34 patients with CKD (Case group), 31 with coronary artery disease undergoing coronary artery bypass graft (CABG, positive control group), and 24 healthy kidney donors (negative control group). For histopathological assessment of atherosclerosis, arterial tissue samples were obtained from the patients in each study group. The cIMT and fIMTs were measured by ultrasonography. Results: Histopathological atherosclerosis was present in 82.3, 100, and 20.8% of CKD, CABG, and donor groups respectively (p < 0.001). CKD patients had higher values of cIMT and fIMT than the donor group (p = 0.01 and 0.004, respectively). cIMT was positively correlated with the grade of atherosclerosis in the CKD group only (p < 0.001), while fIMT was correlated with the grade of atherosclerosis in both CKD and donor groups (p < 0.001 and p = 0.009 respectively). In CKD patients, cIMT >0.65 mm and femoral values >0.57 mm predicted the presence of histopathological atherosclerosis with sensitivities of 96 and 92% respectively. Conclusion: Higher values of cIMT and fIMT in CKD patients are associated with higher rates and degrees of histopathological atherosclerosis. Additionally, when compared to fIMT, cIMT has a higher sensitivity for detecting atherosclerosis in CKD patients.

© 2018 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Clinical Practice: Original Paper

Received: November 01, 2017
Accepted: February 03, 2018
Published online: March 07, 2018
Issue release date: May 2018

Number of Print Pages: 11
Number of Figures: 3
Number of Tables: 3

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF

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2018, Vol.139, No. 2

May 2018

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N.N. and K.G. contributed equally to this study. This work was conducted at the Tabriz University of Medical Sciences.

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