Oncology
Clinical Trial Note
Interim Results of a Phase II Study of Hypofractionated Radiotherapy with Concurrent Temozolomide Followed by Adjuvant Temozolomide in Patients over 70 Years Old with Newly Diagnosed GlioblastomaYusuf M.a · Ugiliweneza B.b · Amsbaugh M.e · Boakye M.b · Williams B.b · Nelson M.b · Hattab E.M.c · Woo S.a · Burton E.daDepartment of Radiation Oncology and the James Graham Brown Cancer Center, University of Louisville Hospital, Louisville, KY, USA
bDepartment of Neurosurgery, University of Louisville, Louisville, KY, USA cDepartment of Pathology, University of Louisville, Louisville, KY, USA dDivision of Neuro-Oncology, Department of Neurology, University of Louisville Hospital, Louisville, KY, USA eDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA |
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Article / Publication Details
Received: February 05, 2018
Accepted: March 12, 2018
Published online: April 25, 2018
Issue release date: June 2018
Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 2
ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)
For additional information: https://www.karger.com/OCL
Abstract
Objective: In this phase II study, we investigate clinical outcomes and tolerability of hypofractionated radiotherapy (HRT) combined with temozolomide (TMZ) to treat elderly patients with glioblastoma (GBM). Methods: Patients 70 years of age or older with newly diagnosed GBM received HRT to a dose of 34 Gy given in ten fractions over 2 weeks, delivered with concurrent and adjuvant TMZ. Results: In this interim analysis, ten patients were enrolled on trial from 12/1/2015 to 4/5/2017. With a median follow-up of 9 months (range 3–12 months), median progression-free survival (PFS) was 6 months. The median overall survival (OS) has not been reached. Estimated 1-year OS and PFS rates were 53.3 and 44.4%, respectively. All patients completed the full course of RT, with no patients developing grade 3 or higher adverse events from treatment. Conclusions: The preliminary results of our phase II trial suggest HRT delivered over 2 weeks with concurrent and adjuvant TMZ is well tolerated in elderly patients with GBM without compromising clinical outcomes.
© 2018 S. Karger AG, Basel
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Article / Publication Details
Received: February 05, 2018
Accepted: March 12, 2018
Published online: April 25, 2018
Issue release date: June 2018
Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 2
ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)
For additional information: https://www.karger.com/OCL
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