Login to MyKarger

New to MyKarger? Click here to sign up.



Login with Facebook

Forgot your password?

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login
(Shibboleth or Open Athens)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Surgical Research – General Subjects

Response of Alveolar Macrophages to Inhaled Particulates

Dörger M. · Krombach F.

Author affiliations

Institute for Surgical Research, University of Munich, Germany

Related Articles for ""

Eur Surg Res 2002;34:47–52

Do you have an account?

Login Information





Contact Information










I have read the Karger Terms and Conditions and agree.



Login Information





Contact Information










I have read the Karger Terms and Conditions and agree.



To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!

If you would like to redeem your KAB credit, please log in.


Save over 20% compared to the individual article price.
Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00


Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

Published online: March 14, 2002
Issue release date: 2002

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 0

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: https://www.karger.com/ESR


First-Page Preview
Abstract of Surgical Research – General Subjects

References

  1. McClellan RO: Use of mechanistic data in assessing human risks from exposure to particles. Environ Health Perspect 1997;105(suppl 5):1363–1372.
  2. Paraf F: Smiling alveolar macrophage. N Engl J Med 1998;339:1896
  3. Gardner DE: Alterations in macrophage functions by environmental chemicals. Environ Health Perspect 1984;55:343–358.
    External Resources
  4. Lehnert BE: Pulmonary and thoracic macrophage subpopulations and clearance of particles from the lung. Environ Health Perspect 1992;97:17–46.
  5. Dörger M, Münzing S, Allmeling A-M, Messmer K, Krombach F: Phenotypic and functional differences between rat alveolar, pleural, and peritoneal macrophages. Exp Lung Res 2001;27:65–76.
  6. Krombach F, Gerlach T, Padovan C, Burges A, Behr J, Beinert T, Vogelmeier C: Characterization and quantification of alveolar monocytes in patients with chronic inflammatory lung disease. Eur Respir J 1996;9:984–991.
  7. Fels AO, Cohn ZA: The alveolar macrophage. J Appl Physiol 1986;60:353–369.
  8. Sibille Y, Reynolds HY: Macrophages and polymorphonuclear neutrophils in lung defense and injury. Am Rev Respir Dis 1990;141:471–501.
  9. Warheit DB, Overby LH, George G, Brody AR: Pulmonary macrophages are attracted to inhaled particles through complement activation. Exp Lung Res 1988;14:51–66.
    External Resources
  10. Oberdörster G, Ferin J, Gelein R, Soderholm SC, Finkelstein J: Role of the alveolar macrophage in lung injury: Studies with ultrafine particles. Environ Health Perspect 1992;97:193–199.
  11. Brown EJ: Phagocytosis. Bioessays 1995;17:109–117.
  12. Goldsmith CA, Frevert C, Imrich A, Sioutas C, Kobzik L: Alveolar macrophage interaction with air pollution particles. Environ Health Perspect 1997;105(suppl 5):1191–1195.
  13. Palecanda A, Paulauskis JD, Al-Mutairi E, Imrich A, Qin G, Suzuki H, Kodama T, Tryggvason K, Koziel H, Kobzik L: Role of the scavenger receptor MARCO in alveolar macrophage binding of unopsonized environmental particles. J Exp Med 1999;189:1–10.
  14. Kobzik L, Huang S, Paulauskis JD, Godleski JJ: Particle opsonization and lung macrophage cytokine response. In vitro and in vivo analysis. J Immunol 1993;151:2753–2759.
  15. Dörger M, Münzing S, Allmeling A-M, Messmer K, Krombach F: Differential responses of rat alveolar and peritoneal macrophages to man-made vitreous fibers in vitro. Environ Res 2001;85:207–214.
    External Resources
  16. Lay JC, Bennett WD, Kim CS, Devlin RB, Bromberg PA: Retention and intracellular distribution of instilled iron oxide particles in human alveolar macrophages. Am J Respir Cell Mol Biol 1998;18:687–695.
  17. Kreyling W, Scheuch G: Clearance of particles deposited in the lungs; in Heyder J, Gehr P (eds): Particle Lung Interactions. New York, Marcel Dekker, 2000, pp 323–376.
  18. Dörger M, Münzing S, Allmeling A-M, Krombach F: Comparison of the phagocytic response of rat and hamster alveolar macrophages to man-made vitreous fibers in vitro. Hum Exp Toxicol 2000;19:635–640.
    External Resources
  19. Hext PM: Current perspectives on particulate induced pulmonary tumours. Hum Exp Toxicol 1994;13:700–715.
    External Resources
  20. Warheit DB, Hansen JF, Yuen IS, Kelly DP, Snajdr SI, Hartsky MA: Inhalation of high concentrations of low toxicity dusts in rats results in impaired pulmonary clearance mechanisms and persistent inflammation. Toxicol Appl Pharmacol 1997;145:10–22.
    External Resources
  21. Kreyling WG: Intracellular particle dissolution in alveolar macrophages. Environ Health Perspect 1992;97:121–126.
  22. Li XY, Gilmour PS, Donaldson K, MacNee W: Free radical activity and pro-inflammatory effects of particulate air pollution (PM10) in vivo and in vitro. Thorax 1996;51:1216–1222.
  23. Sies H: Oxidative stress: Oxidants and antioxidants. Exp Physiol 1997;82:291–295.
  24. Martin LD, Krunkosky TM, Dye JA, Fischer BM, Jiang NF, Rochelle LG, Akley NJ, Dreher KL, Adler KB: The role of reactive oxygen and nitrogen species in the response of airway epithelium to particles. Environ Health Perspect 1997;105(suppl 5):1301–1307.
  25. Rahman Q, Norwood J, Hatch G: Evidence that exposure of particulate air pollutants to human and rat alveolar macrophages leads to differential oxidative response. Biochem Biophys Res Commun 1997;240:669–672.
    External Resources
  26. Becker S, Soukup JM, Gilmour MI, Devlin RB: Stimulation of human and rat alveolar macrophages by urban air particles: Effects on oxidant radical generation and cytokine production. Toxicol Appl Pharmacol 1996;141:637–648.
  27. Hansen K, Mossman BT: Generation of superoxide from alveolar macrophages exposed to asbestiform and nonfibrous particles. Cancer Res 1987;47:1681–1686.
  28. Donaldson K, Hill IM, Beswick PH: Superoxide anion release by alveolar macrophages exposed to respirable industrial fibers: Modifying effect of fibre opsonization. Exp Toxicol Pathol 1995;47:229–231.
    External Resources
  29. Perkins RC, Scheule RK, Holian A: In vitro bioactivity of asbestos for the human alveolar macrophage and its modification by IgG. Am J Respir Cell Mol Biol 1991;4:532–537.
  30. Thomas G, Ando T, Verma K, Kagan E: Asbestos fibers and interferon-gamma up-regulate nitric oxide production in rat alveolar macrophages. Am J Respir Cell Mol Biol 1994;11:707–715.
  31. Tanaka S, Choe N, Hemenway DR, Zhu S, Matalon S, Kagan E: Asbestos inhalation induces reactive nitrogen species and nitrotyrosine formation in the lungs and pleura of the rat. J Clin Invest 1998;102:445–454.
  32. Quinlan TR, BeruBe KA, Hacker MP, Taatjes DJ, Timblin CR, Goldberg J, Kimberly P, O’Shaugnessy PO, Hemenway D, Torino J, Jiminez LA, Mossman BT: Mechanisms of asbestos-induced nitric oxide production by rat alveolar macrophages in inhalation and in vitro models. Free Radic Biol Med 1998;24:778–788.
  33. Iguchi H, Kojo S, Ikeda M: Nitric oxide (NO) synthase activity in the lung and NO synthesis in alveolar macrophages of rats increased on exposure to asbestos. J Appl Toxicol 1996;16:309–315.
  34. Castranova V, Huffmann LJ, Judy DJ, Bylander JE, Lapp LN, Weber SL, Blackford JA, Dey RD: Enhancement of nitric oxide production by pulmonary cells following silica exposure. Environ Health Perspect 1998;106(suppl 5):1165–1169.
  35. Blackford JA Jr, Jones W, Dey RD, Castranova V: Comparison of inducible nitric oxide synthase gene expression and lung inflammation following intratracheal instillation of silica, coal, carbonyl iron, or titanium dioxide in rats. J Toxicol Environ Health 1997;51:203–218.
  36. Fubini B, Aust AE, Bolton RE, Borm PJ, Bruch J, Ciapetti G, Donaldson K, Elias Z, Gold J, Jaurand M-C, Kane AB, Lison D, Muhle H: Non-animal tests for evaluating the toxicity of solid xenobiotics. ATLA 1998;26:579–617.
  37. Driscoll KE, Carter JM, Hassenbein DG, Howard B: Cytokines and particle-induced inflammatory cell recruitment. Environ Health Perspect 1997;105(suppl 5):1159–1164.
  38. Lemaire I, Ouellet S: Distinctive profile of alveolar macrophage-derived cytokine release induced by fibrogenic and nonfibrogenic mineral dusts. J Toxicol Environ Health 1996;47:465–478.
  39. Drumm K, Buhl R, Kienast K: Additional NO2 exposure induces a decrease in cytokine specific mRNA expression and cytokine release of particle and fibre exposed human alveolar macrophages. Eur J Med Res 1999;4:59–66.
    External Resources
  40. Adamson IYR, Bowden DH: Pulmonary reaction to long and short asbestos fibers is independent of fibroblast growth factor production by alveolar macrophages. Am J Pathol 1990;137:523–529.
  41. Bonner JC, Osornio VA, Badgett A, Brody AR: Differential proliferation of rat lung fibroblasts induced by the platelet-derived growth factor-AA, -AB, and -BB isoforms secreted by rat alveolar macrophages. Am J Respir Cell Mol Biol 1991;5:539–547.
  42. Bissonnette E, Rola PM: Pulmonary inflammation and fibrosis in a murine model of asbestosis and silicosis. Possible role of tumor necrosis factor. Inflammation 1989;13:329–339.
  43. Davies R, Erdogdu G: Secretion of fibronectin by mineral dust-derived alveolar macrophages and activated peritoneal macrophages. Exp Lung Res 1989;15:285–297.
  44. Koren HS, Joyce M, Devlin RB, Becker S, Driscoll K, Madden MC: Modulation of eicosanoid production by human alveolar macrophages exposed to silica in vitro. Environ Health Perspect 1992;97:77–83.
  45. Dubois CM, Bissonnette E, Rola PM: Asbestos fibers and silica particles stimulate rat alveolar macrophages to release tumor necrosis factor. Autoregulatory role of leukotriene B4. Am Rev Respir Dis 1989;139:1257–1264.
    External Resources
  46. Bissonnette E, Carre B, Dubois C, Rola PM: Inhibition of alveolar macrophage cytotoxicity by asbestos: Possible role of prostaglandins. J Leukoc Biol 1990;47:129–134.
    External Resources
  47. Gercken G, Berg I, Dörger M, Schlüter T: Mechanisms of particle-induced activation of alveolar macrophages. Toxicol Lett 1996;88:121–129.
    External Resources
  48. Wang QE, Han CH, Wu WD, Wang HB, Liu SJ, Kohyama N: Biological effects of man-made mineral fibers (I) – Reactive oxygen species production and calcium homeostasis in alveolar macrophages. Ind Health 1999;37:62–67.
    External Resources
  49. Drumm K, Oettinger R, Smolarski R, Bay M, Kienast K: In vitro study of human alveolar macrophages inflammatory mediator transcriptions and releases induced by soot FR 101, Printex 90, titandioxide and Chrysotile B. Eur J Med Res 1998;3:432–438.
    External Resources
  50. Sen CK, Packer L: Antioxidant and redox regulation of gene transcription. FASEB J 1996;10:709–720.
  51. Pepperl S, Dörger M, Ringel F, Kupatt C, Krombach F: Hyperoxia upregulates the NO pathway in alveolar macrophages in vitro: Role of AP-1 and NF-kappaB. Am J Physiol Lung Cell Mol Physiol 2001;280:L905–L913.
    External Resources
  52. Gilmour PS, Brown DM, Beswick PH, MacNee W, Rahman I, Donaldson K: Free radical activity of industrial fibers: Role of iron in oxidative stress and activation of transcription factors. Environ Health Perspect 1997;105(suppl 5):1313–1317.
  53. Warheit DB, Hartsky M: Influences of gender, species, and strain differences in pulmonary toxicological assessments of inhaled particles and/or fibers; in Mohr U (ed): Toxic and Carcinogenic Effects of Solid Particles in the Respiratory Tract. Washington, ILSI Press, 1994, pp 253–265.
  54. Warheit DB, Hartsky MA: Role of alveolar macrophage chemotaxis and phagocytosis in pulmonary clearance responses to inhaled particles: Comparisons among rodent species. Microsc Res Tech 1993;26:412–422.
  55. Krombach F, Münzing S, Allmeling A-M, Gerlach JT, Behr J, Dörger M: Cell size of alveolar macrophages: an interspecies comparison. Environ Health Perspect 1997;105(suppl 5):1261–1263.
  56. Dörger M, Allmeling A-M, Neuber A, Behr J, Rambeck W, Krombach F: Interspecies comparison of rat and hamster alveolar macrophage antioxidative and oxidative capacity. Environ Health Perspect 1997;105(suppl 5):1309–1312.
  57. Dörger M, Jesch NK, Rieder G, Hirvonen M-R, Savolainen K, Krombach F, Messmer K: Species differences in NO formation by rat and hamster alveolar macrophages in vitro. Am J Respir Cell Mol Biol 1997;16:413–420.
  58. Jesch NK, Dörger M, Enders G, Rieder G, Vogelmeier C, Messmer K, Krombach F: Expression of inducible nitric oxide synthase and formation of nitric oxide by alveolar macrophages: An interspecies comparison. Environ Health Perspect 1997;105(suppl 5):1297–1300.
  59. Bryan CL, Jenkinson SG: Species variation in lung antioxidant enzyme activities. J Appl Physiol 1987;63:597–602.
    External Resources
  60. Heinrich U, Muhle H, Takenaka S, Ernst H, Fuhst R, Mohr U, Pott F, Stöber W: Chronic effects on the respiratory tract of hamsters, mice and rats after long-term inhalation of high concentrations of filtered and unfiltered diesel engine emissions. J Appl Toxicol 1986;6:383–395.

Article / Publication Details

Published online: March 14, 2002
Issue release date: 2002

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 0

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: https://www.karger.com/ESR


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.