Neonatology

Original Paper

Reduced Prevalence of Severe Intraventricular Hemorrhage in Very Preterm Infants Delivered after Maternal Preeclampsia

Morsing E.a · Maršál K.b · Ley D.a

Author affiliations

aDepartment of Pediatrics, Clinical Sciences Lund, Lund University, Lund, Sweden
bDepartment of Obstetrics and Gynecology, Clinical Sciences Lund, Lund University, Lund, Sweden

Keywords: PreeclampsiaIntraventricular hemorrhageNeonateVery preterm birth

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Neonatology 2018;114:205–211
https://doi.org/10.1159/000489039

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 10, 2017
Accepted: April 07, 2018
Published online: June 25, 2018
Issue release date: September 2018

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 5

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

Abstract

Background: Very preterm (VPT) delivery after severe preeclampsia (PE) has been associated with adverse perinatal outcome. It is unclear whether fetal exposure to PE per se modifies the prevalence of neonatal morbidities associated with VPT birth. Objectives: To evaluate neonatal morbidity in VPT infants exposed to maternal PE compared to morbidity in nonexposed VPT infants. Methods: This retrospective study consisted of all inborn infants delivered before 30 gestational weeks admitted to a tertiary-level neonatal intensive care unit between 1998 and 2014: 195 infants exposed to maternal PE were compared to 957 infants without maternal PE (background group). Prevalence rates of neonatal morbidity, cerebral palsy (CP), and mortality at 2 years of age were obtained from patient records. Results: The PE group had a lower median (IQR) birth weight (795 [262] g) and a higher median gestational age (GA) (27 [3] weeks) at birth than the background group (890 [385] g and 26 [3] weeks, respectively; both p < 0.001). Exposure to maternal PE was associated with lower rates of severe intraventricular hemorrhage (IVH) (2 vs. 11%), retinopathy of prematurity requiring treatment (2 vs. 7%), mortality (9 vs. 15%), and CP (4 vs. 8%). Exposure to PE remained associated with a reduced prevalence of severe IVH (OR 0.17, 95% CI 0.05–0.57) after adjustment for GA, multiple birth, Apgar score, delivery mode, sex, and antenatal steroid treatment. Conclusion: Fetal exposure to PE is associated with a decreased rate of severe IVH following VPT birth. Studies on underlying mechanisms may provide a basis for prevention of IVH in the VPT infant.

© 2018 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 10, 2017
Accepted: April 07, 2018
Published online: June 25, 2018
Issue release date: September 2018

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 5

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

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2018, Vol.114, No. 3

September 2018

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