0 item
0 item
Login
Help

Login to MyKarger

New to MyKarger? Click here to sign up.



Login with Facebook

Forgot your password?

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login
(Shibboleth or OpenAthens)

For the academic login, please select your organization on the next page. You will be redirected to verify your credentials.

OpenAthens/Shibboleth

Journal Menu

Editorial

Open Access Gateway

The Dark Side of the Long-Term Use of Proton Pump Inhibitors in Chronic Liver Disease

Fernandes S.R. · Tato Marinho R.

Author affiliations

Serviço de Gastrenterologia e Hepatologia, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon, Portugal

Corresponding Author

Prof. Rui Tato Marinho

Serviço de Gastrenterologia e Hepatologia

Hospital de Santa Maria, Centro Hospitalar Lisboa Norte

Av. Prof. Egas Moniz, PT–1649-035 Lisbon (Portugal)

E-Mail ruitatomarinho@sapo.pt

Keywords: Proton pump inhibitorsDyspepsiaCirrhosisSpontaneous bacterial peritonitis

Related Articles for ""
GE Port J Gastroenterol 2019;26:79–80
https://doi.org/10.1159/000489640

Do you have an account?

Login Information





Contact Information











I have read the Karger Terms and Conditions and agree.




First-Page Preview
Abstract of Editorial

O ladro negro da utilização crónica de inibidores da bomba de protões na doença hepática crónica

Palavras Chave

Inibidores da bomba de protões · Dispepsia · Cirrose · Peritonite bacteriana espontânea ·



Related Articles:

References

  1. Mat Saad AZ, Collins N, Lobo MM, O’Connor HJ: Proton pump inhibitors: a survey of prescribing in an Irish general hospital. Int J Clin Pract 2005; 59: 31–34.
    External Resources
  2. Ahrens D, Chenot JF, Behrens G, Grimmsmann T, Kochen MM: Appropriateness of treatment recommendations for PPI in hospital discharge letters. Eur J Clin Pharmacol 2010; 66: 1265–1271.
    External Resources
  3. Targownik L: Discontinuing long-term PPI therapy: why, with whom, and how? Am J Gastroenterol 2018; 113: 519–528.
    External Resources
  4. Xavier S, Magalhães J, Cotter J: Proton pump inhibitors: are they a real threat to the patient? GE Port J Gastroenterol 2018, DOI: 10.1159/ 000487154.
    External Resources
  5. Schoenfeld AJ, Grady D: Adverse effects associated with proton pump inhibitors. JAMA Intern Med 2016; 176: 172–174.
    External Resources
  6. Lim KH, Potts JR, Chetwood J, Goubet S, Verma S: Long-term outcomes after hospitalization with spontaneous bacterial peritonitis. J Dig Dis 2015; 16: 228–240.
    External Resources
  7. Ono Y, Watanabe T, Matsumoto K, Ito T, Kunii O, Goldstein E: Opsonophagocytic dysfunction in patients with liver cirrhosis and low responses to tumor necrosis factor-alpha and lipopolysaccharide in patients’ blood. J Infect Chemother 2004; 10: 200–207.
    External Resources
  8. Pande C, Kumar A, Sarin SK: Small-intestinal bacterial overgrowth in cirrhosis is related to the severity of liver disease. Aliment Pharmacol Ther 2009; 29: 1273–1281.
    External Resources
  9. Parkman HP, Urbain JL, Knight LC, et al: Effect of gastric acid suppressants on human gastric motility. Gut 1998; 42: 243–250.
    External Resources
  10. Kalaitzakis E, Björnsson E: Inadequate use of proton-pump inhibitors in patients with liver cirrhosis. Eur J Gastroenterol Hepatol 2008; 20: 512–518.
    External Resources
  11. Cahir C, Fahey T, Tilson L, Teljeur C, Bennett K: Proton pump inhibitors: potential cost reductions by applying prescribing guidelines. BMC Health Services Research 2012; 12: 408.
    External Resources
  12. Elzouki A, Neffati N, Rasoul F, Abdallah A, Othman M, Waness A: Increased risk of Spontaneous bacterial peritonitis in cirrhotic patients using proton pump inhibitors. GE Port J Gastroenterol 2018, in press.
    External Resources
  13. Elkrief L, Rautou PE, Sarin S, Valla D, Paradis V, Moreau R: Diabetes mellitus in patients with cirrhosis: clinical implications and management. Liver Int 2016; 36: 936–948.
    External Resources
  14. Yu T, Tang Y, Jiang L, Zheng Y, Xiong W, Lin L: Proton pump inhibitor therapy and its association with spontaneous bacterial peritonitis incidence and mortality: a meta-analysis. Dig Liver Dis 2016; 48: 353–359.
    External Resources
  15. Xu HB, Wang HD, Li CH, Ye S, Dong MS, Xia QJ, Zhang AQ, Pan K, Ge XL, Dong JH: Proton pump inhibitor use and risk of spontaneous bacterial peritonitis in cirrhotic patients: a systematic review and meta-analysis. Genet Mol Res 2015; 14: 7490–7501.
    External Resources
  16. Gonzalez-Gonzalez JA, Garcia-Compean D, Vazquez-Elizondo G, Garza-Galindo A, Jaquez-Quintana JO, Maldonado-Garza H: Nonvariceal upper gastrointestinal bleeding in patients with liver cirrhosis. Clinical features, outcomes and predictors of in-hospital mortality. A prospective study. Ann Hepatol 2011; 10: 287–295.
    External Resources
  17. Rudler M, Rousseau G, Benosman H, Massard J, Deforges L, Lebray P, Poynard T, Thabut D: Peptic ulcer bleeding in patients with or without cirrhosis: different diseases but the same prognosis? Aliment Pharmacol Ther 2012; 36: 166–172.
    External Resources

Article / Publication Details

Received: April 19, 2018
Accepted: April 26, 2018
Published online: May 25, 2018
Issue release date: March - April

Number of Print Pages: 2
Number of Figures: 0
Number of Tables: 0

ISSN: 2341-4545 (Print)
eISSN: 2387-1954 (Online)

For additional information: https://www.karger.com/PJG

References

  1. Mat Saad AZ, Collins N, Lobo MM, O’Connor HJ: Proton pump inhibitors: a survey of prescribing in an Irish general hospital. Int J Clin Pract 2005; 59: 31–34.
    External Resources
  2. Ahrens D, Chenot JF, Behrens G, Grimmsmann T, Kochen MM: Appropriateness of treatment recommendations for PPI in hospital discharge letters. Eur J Clin Pharmacol 2010; 66: 1265–1271.
    External Resources
  3. Targownik L: Discontinuing long-term PPI therapy: why, with whom, and how? Am J Gastroenterol 2018; 113: 519–528.
    External Resources
  4. Xavier S, Magalhães J, Cotter J: Proton pump inhibitors: are they a real threat to the patient? GE Port J Gastroenterol 2018, DOI: 10.1159/ 000487154.
    External Resources
  5. Schoenfeld AJ, Grady D: Adverse effects associated with proton pump inhibitors. JAMA Intern Med 2016; 176: 172–174.
    External Resources
  6. Lim KH, Potts JR, Chetwood J, Goubet S, Verma S: Long-term outcomes after hospitalization with spontaneous bacterial peritonitis. J Dig Dis 2015; 16: 228–240.
    External Resources
  7. Ono Y, Watanabe T, Matsumoto K, Ito T, Kunii O, Goldstein E: Opsonophagocytic dysfunction in patients with liver cirrhosis and low responses to tumor necrosis factor-alpha and lipopolysaccharide in patients’ blood. J Infect Chemother 2004; 10: 200–207.
    External Resources
  8. Pande C, Kumar A, Sarin SK: Small-intestinal bacterial overgrowth in cirrhosis is related to the severity of liver disease. Aliment Pharmacol Ther 2009; 29: 1273–1281.
    External Resources
  9. Parkman HP, Urbain JL, Knight LC, et al: Effect of gastric acid suppressants on human gastric motility. Gut 1998; 42: 243–250.
    External Resources
  10. Kalaitzakis E, Björnsson E: Inadequate use of proton-pump inhibitors in patients with liver cirrhosis. Eur J Gastroenterol Hepatol 2008; 20: 512–518.
    External Resources
  11. Cahir C, Fahey T, Tilson L, Teljeur C, Bennett K: Proton pump inhibitors: potential cost reductions by applying prescribing guidelines. BMC Health Services Research 2012; 12: 408.
    External Resources
  12. Elzouki A, Neffati N, Rasoul F, Abdallah A, Othman M, Waness A: Increased risk of Spontaneous bacterial peritonitis in cirrhotic patients using proton pump inhibitors. GE Port J Gastroenterol 2018, in press.
    External Resources
  13. Elkrief L, Rautou PE, Sarin S, Valla D, Paradis V, Moreau R: Diabetes mellitus in patients with cirrhosis: clinical implications and management. Liver Int 2016; 36: 936–948.
    External Resources
  14. Yu T, Tang Y, Jiang L, Zheng Y, Xiong W, Lin L: Proton pump inhibitor therapy and its association with spontaneous bacterial peritonitis incidence and mortality: a meta-analysis. Dig Liver Dis 2016; 48: 353–359.
    External Resources
  15. Xu HB, Wang HD, Li CH, Ye S, Dong MS, Xia QJ, Zhang AQ, Pan K, Ge XL, Dong JH: Proton pump inhibitor use and risk of spontaneous bacterial peritonitis in cirrhotic patients: a systematic review and meta-analysis. Genet Mol Res 2015; 14: 7490–7501.
    External Resources
  16. Gonzalez-Gonzalez JA, Garcia-Compean D, Vazquez-Elizondo G, Garza-Galindo A, Jaquez-Quintana JO, Maldonado-Garza H: Nonvariceal upper gastrointestinal bleeding in patients with liver cirrhosis. Clinical features, outcomes and predictors of in-hospital mortality. A prospective study. Ann Hepatol 2011; 10: 287–295.
    External Resources
  17. Rudler M, Rousseau G, Benosman H, Massard J, Deforges L, Lebray P, Poynard T, Thabut D: Peptic ulcer bleeding in patients with or without cirrhosis: different diseases but the same prognosis? Aliment Pharmacol Ther 2012; 36: 166–172.
    External Resources

Open Access License / Drug Dosage / Disclaimer

This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Top

Article Tools
Article Details

2019, Vol.26, No. 2

March - April

Open Access Gateway

previous Article next

Recommend This
Open Access Gateway