Leksell Radiosurgery

Editor(s): Niranjan, Ajay (Pittsburgh, PA)
Lunsford, L. Dade (Pittsburgh, PA)
Kano, Hideyuki (Pittsburgh, PA)

Tumor Radiosurgery

Guidelines for Multiple Brain Metastases Radiosurgery

Niranjan A.a · Monaco E.a · Flickinger J.b · Lunsford L.D.a

Author affiliations

aDepartments of Neurological Surgery and Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, USA
bCenter for Image-Guided Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

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Niranjan A, Lunsford LD, Kano H (eds): Leksell Radiosurgery. Prog Neurol Surg. Basel, Karger, 2019, vol 34, pp 100–109 (DOI: 10.1159/000493055)
https://doi.org/10.1159/000493055

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Article / Publication Details

First-Page Preview
Abstract of Tumor Radiosurgery

Published online: May 16, 2019
Cover Date: 2018

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 0

ISBN: 978-3-318-06421-6 (Print)
eISBN: 978-3-318-06422-3 (Online)

Abstract

Stereotactic radiosurgery (SRS) is an effective treatment for patients with multiple brain metastases. Three decades of increasingly powerful scientific studies have shown that SRS improves outcomes and reduces toxicity when it replaces whole-brain radiation therapy (WBRT). Expert opinion surveys of clinicians have reported that the total intracranial tumor volume rather than the number of brain metastases is related to outcomes. As a result, an increasing number of treating and referring physicians have replaced the reflex use of WBRT with SRS, unless the patient has miliary disease or carcinomatous meningitis. In the current era of immunotherapy and targeted therapies with potentially increased systemic disease survival, 10 or more tumors are routinely treated with SRS alone at most academic medical centers. In a single SRS session we routinely treat patients with cumulative tumor volumes of 25 cm3 even if they have ≥10 metastases.

© 2019 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Tumor Radiosurgery

Published online: May 16, 2019
Cover Date: 2018

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 0

ISBN: 978-3-318-06421-6 (Print)
eISBN: 978-3-318-06422-3 (Online)

Copyright / Drug Dosage / Disclaimer

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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