Skin Pharmacology and Physiology

Research Article

In vivo Human Skin Penetration of the UV Filter Ethylhexyl Triazone: Effect of Lipid Microparticle Encapsulation

Scalia S. · Battaglioli S. · Bianchi A.

Author affiliations

Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy

Keywords: SunscreensEthylhexyl triazonePercutaneous penetrationIn vivo studyTape strippingLipid microparticles

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Skin Pharmacol Physiol 2019;32:22–31
https://doi.org/10.1159/000493761

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Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: July 24, 2018
Accepted: September 13, 2018
Published online: October 31, 2018
Issue release date: December 2018

Number of Print Pages: 10
Number of Figures: 5
Number of Tables: 3

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: https://www.karger.com/SPP

Abstract

Background/Aims: The data available on the skin permeability of ethylhexyl triazone (EHT), a widely used high-molecular-weight (823.1-Da) UV filter, are scarce and obtained only via in vitro studies. Therefore, we evaluated in vivo the penetration of EHT in human stratum corneum by the tape stripping technique. Moreover, the effect of EHT encapsulation in lipid microparticles (LMs) on its diffusion through the stratum corneum was examined. Methods: LMs loaded with EHT were prepared using glyceryl behenate and phosphatidylcholine. Creams containing EHT free or encapsulated in LMs in conjunction with the two most commonly used UV filters, octyl methoxycinnamate (OMC) and butyl methoxydibenzoylmethane (BMDBM), were applied to human volunteers and the fraction of the applied sunscreen dose having penetrated into different stratum corneum layers was measured. Results and Conclusion: For the cream with the nonencapsulated sunscreen agent, the percentage of the applied EHT dose diffused into the stratum corneum was 21.9 ± 4.9%, not significantly different from that of the smaller-molecular-weight OMC (22.2 ± 7.6%) and BMDBM (20.5 ± 3.7%). A marked (45.7%) and statistically significant reduction in the in vivo skin penetration of EHT was attained with the cream containing microencapsulated EHT. The decreased percutaneous penetration provided by the LMs should favor the efficacy of EHT and limit potential toxicological risks.

© 2018 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: July 24, 2018
Accepted: September 13, 2018
Published online: October 31, 2018
Issue release date: December 2018

Number of Print Pages: 10
Number of Figures: 5
Number of Tables: 3

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: https://www.karger.com/SPP

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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2019, Vol.32, No. 1

December 2018

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