Pharmacology

Research Article

ErbB4 Receptors in the Medial Habenula Regulate Contextual Fear Memory

Geng F.a · Liu J.-Y.b · Chen X.-W.b · Zou W.-J.c · Wu J.-L.c · Rodriguez G.d · Peng C.c · Tian J.e · Lu G.-F.b

Author affiliations

aDepartment of Physiology, Zunyi Medical College, Zunyi, China
bDepartment of Pathophysiology, Zunyi Medical College, Zunyi, China
cDepartment of Neurobiology, Southern Medical University, Guangzhou, China
dDepartment of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
eCollege of Biological Science and Technology, Heilongjiang BaYi Agriculture University, Daqing, China

Keywords: HabenulaMedial habenulaErbB4 receptorContextual fear memoryGamma-amino butyric acid release

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Pharmacology 2019;103:68–75
https://doi.org/10.1159/000495064

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Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: March 07, 2017
Accepted: November 02, 2018
Published online: December 04, 2018
Issue release date: February 2019

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 1

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA

Abstract

The Medial Habenular (MHb) and the Lateral Habenular nuclei are 2 main parts of the habenular complex (Hb). Recent studies showed that MHb plays an important role in memory, and in the expression of ErbB4. However, the expression of MHb ErbB4 receptor and its role in fear memory is not well understood. In this study, western blotting and quantitative real-time polymerase chain reaction were used to assess the protein and mRNA levels of ErbB4 in the process of contextual fear conditioning. A pharmacological approach was used to block and stimulate the ErbB4 receptor. Contextual fear conditioning tests induced a significant increase on the expression of ErbB4 at various times in the Hb and the MHb. Moreover, the blockade and stimulation of MHb ErbB4 receptors did not affect the fear formation but impaired and improved the contextual-dependent fear expression. Furthermore, in vitro electrophysiological recordings showed that the blockade of the MHb ErbB4 receptor reduced the presynaptic gamma-amino butyric acid release. ErbB4 is a susceptible gene for schizophrenia and the above findings may provide new insights into the mechanisms of fear-related responses.

© 2018 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: March 07, 2017
Accepted: November 02, 2018
Published online: December 04, 2018
Issue release date: February 2019

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 1

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA

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2019, Vol.103, No. 1-2

February 2019

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