Intervirology

Original Paper

Human Papillomavirus in Thai Women and Men with Anogenital Warts

Nilyanimit P.a · Chansaenroj J.a · Srisomboon J.b · Rodrangnok W.c · Rajakom N.c · Daengsaard E.c · Sookrak N.c · Poovorawan Y.a

Author affiliations

aCenter of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
bDepartment of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
cBangrak Sexually Transmitted Infections Center, Bangkok, Thailand

Keywords: Human papillomavirusAnogenital wartSexual behavior

Related Articles for ""
Intervirology 2018;61:223–229
https://doi.org/10.1159/000497351

Log in to MyKarger to check if you already have access to this content.




Forgot your password
Sign up to MyKarger

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more
CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!


If you would like to redeem your KAB credit, please log in.

Save over 20% compared to the individual article price.

Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates

Select
* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 12, 2018
Accepted: January 24, 2019
Published online: March 22, 2019
Issue release date: April 2019

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 2

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: https://www.karger.com/INT

Abstract

Objective: Anogenital warts are caused by human papillomavirus (HPV). Globally, HPV genotypes 6 and 11 are most often associated with anogenital warts. However, the diversity of HPV genotypes found in patients with genital warts in Thailand is unknown. The aim of this study was to investigate HPV-associated anogenital warts in the Thai population and to assess whether genotypes found are represented in the bivalent and quadrivalent HPV vaccine. Methods: This study included 206 anogenital swab samples from patients who were diagnosed with anogenital warts. Detection of HPV DNA was performed using polymerase chain reaction to amplify the L1 gene and sequencing. Results: HPV was identified in 88.3% (182/206) of the samples. The majority of HPV genotypes were low-risk genotypes HPV6 (36.9%) and HPV11 (36.4%), which represented the most common infection found in genital warts in this study. Conclusion: Immunization with the quadrivalent vaccine (HPV6, HPV11, HPV16, and HPV18) could potentially prevent genital warts caused by HPV infection.

© 2019 S. Karger AG, Basel



Related Articles:

References

  1. Ghadishah D. Condyloma acuminata. eMedicine 2017 [cited 2017 January 5]. Available from: http://emedicine.medscape.com/article/781735-overview
  2. Cox JT. Epidemiology and natural history of HPV. J Fam Pract. 2006 Nov;Suppl:3–9.
    External Resources
  3. Lacey CJ, Woodhall SC, Wikstrom A, Ross J. 2012 European guideline for the management of anogenital warts. J Eur Acad Dermatol Venereol. 2013 Mar;27(3):e263–70.
    External Resources
  4. Camenga DR, Dunne EF, Desai MM, Gee J, Markowitz LE, Desiliva A, et al. Incidence of genital warts in adolescents and young adults in an integrated health care delivery system in the United States before human papillomavirus vaccine recommendations. Sex Transm Dis. 2013 Jul;40(7):534–8.
    External Resources
  5. Gall SA. Female genital warts: global trends and treatments. Infect Dis Obstet Gynecol. 2001;9(3):149–54.
    External Resources
  6. Koutsky L. Epidemiology of genital human papillomavirus infection. Am J Med. 1997 May;102 5A:3–8.
    External Resources
  7. Sénécal M, Brisson M, Maunsell E, Ferenczy A, Franco EL, Ratnam S, et al. Loss of quality of life associated with genital warts: baseline analyses from a prospective study. Sex Transm Infect. 2011 Apr;87(3):209–15.
    External Resources
  8. Woodhall S, Ramsey T, Cai C, Crouch S, Jit M, Birks Y, et al. Estimation of the impact of genital warts on health-related quality of life. Sex Transm Infect. 2008 Jun;84(3):161–6.
    External Resources
  9. Clarke P, Ebel C, Catotti DN, Stewart S. The psychosocial impact of human papillomavirus infection: implications for health care providers. Int J STD AIDS. 1996 May-Jun;7(3):197–200.
    External Resources
  10. Gearhart PA, Randall TC, Buckley RM. Human papillomavirus. eMedicine 2017 [cited 2017 Aug 10]. Available from: http://www.emedicine.com/MED/topic1037.htm
  11. Bhatia N, Lynde C, Vender R, Bourcier M. Understanding genital warts: epidemiology, pathogenesis, and burden of disease of human papillomavirus. J Cutan Med Surg. 2013 Dec;17 Suppl 2:S47–54.
    External Resources
  12. Lacey CJ, Lowndes CM, Shah KV. Chapter 4: burden and management of non-cancerous HPV-related conditions: HPV-6/11 disease. Vaccine 2006;24 Suppl 3:S3/35–41.
  13. Bosch FX, Broker TR, Forman D, Moscicki AB, Gillison ML, Doorbar J, et al; authors of ICO Monograph Comprehensive Control of HPV Infections and Related Diseases Vaccine Volume 30, Supplement 5, 2012. Comprehensive control of human papillomavirus infections and related diseases. Vaccine. 2013 Dec;31 Suppl 7:H1–31.
    External Resources
  14. Dunne EF, Burstein GR, Stone KM. Anogenital human papillomavirus infection in males. Adolesc Med. 2003 Oct;14(3):613–32.
    External Resources
  15. Jamshidi M, Shekari M, Nejatizadeh AA, Malekzadeh K, Baghershiroodi M, Davudian P, et al. The impact of human papillomavirus (HPV) types 6, 11 in women with genital warts. Arch Gynecol Obstet. 2012 Nov;286(5):1261–7.
    External Resources
  16. Arroyo LS, Basaras M, Arrese E, Hernáez S, Esteban V, Cisterna R. Distribution of genital human papillomavirus genotypes in benign clinical manifestations among men from Northern Spain. BMC Public Health. 2016 Jan;16(1):81.
    External Resources
  17. McCormack PL, Joura EA. Spotlight on quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine (Gardasil®) in the prevention of premalignant genital lesions, genital cancer, and genital warts in women. BioDrugs. 2011 Oct;25(5):339–43.
    External Resources
  18. Petrosky E, Bocchini JA Jr, Hariri S, Chesson H, Curtis CR, Saraiya M, et al.; Centers for Disease Control and Prevention (CDC). Use of 9-valent human papillomavirus (HPV) vaccine: updated HPV vaccination recommendations of the advisory committee on immunization practices. MMWR Morb Mortal Wkly Rep. 2015 Mar;64(11):300–4.
    External Resources
  19. de Roda Husman AM, Walboomers JM, van den Brule AJ, Meijer CJ, Snijders PJ. The use of general primers GP5 and GP6 elongated at their 3′ ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR. J Gen Virol. 1995 Apr;76(Pt 4):1057–62.
    External Resources
  20. Lurchachaiwong W, Junyangdikul P, Payungporn S, Chansaenroj J, Sampatanukul P, Tresukosol D, et al. Relationship between hybrid capture II ratios and DNA amplification of E1, E6 and L1 genes used for the detection of human papillomavirus in samples with different cytological findings. Asian Pac J Allergy Immunol. 2009 Dec;27(4):217–24.
    External Resources
  21. Shadrina MI, Semenova EV, Slominsky PA, Bagyeva GH, Illarioshkin SN, Ivanova-Smolenskaia II, et al. Effective quantitative real-time polymerase chain reaction analysis of the parkin gene (PARK2) exon 1–12 dosage. BMC Med Genet 2007;26:6.
  22. Chayachinda C, Boriboonhirunsarn D, Thamkhantho M, Nuengton C, Chalermchockcharoenkit A. Number of external anogenital warts is associated with the occurrence of abnormal cervical cytology. Asian Pac J Cancer Prev. 2014;15(3):1177–80.
    External Resources
  23. Schiffman M, Castle PE, Jeronimo J, Rodriguez AC, Wacholder S. Human papillomavirus and cervical cancer. Lancet. 2007 Sep;370(9590):890–907.
    External Resources
  24. Chang L, Ci P, Shi J, Zhai K, Feng X, Colombara D, et al. Distribution of genital wart human papillomavirus genotypes in China: a multi-center study. J Med Virol. 2013 Oct;85(10):1765–74.
    External Resources
  25. Fleider LA, Tatti SA, Suzuki AV, Maldonado VA, Díaz LB, Chiesa IJ, et al. Human Papillomavirus Types Involved in External Genital Warts in a Group of Argentinian Women in Buenos Aires. J Low Genit Tract Dis. 2016 Oct;20(4):365–6.
    External Resources
  26. Aubin F, Prétet JL, Jacquard AC, Saunier M, Carcopino X, Jaroud F, et al.; EDiTH Study Group. Human papillomavirus genotype distribution in external acuminata condylomata: a Large French National Study (EDiTH IV). Clin Infect Dis. 2008 Sep;47(5):610–5.
    External Resources
  27. Brown DR, Schroeder JM, Bryan JT, Stoler MH, Fife KH. Detection of multiple human papillomavirus types in Condylomata acuminata lesions from otherwise healthy and immunosuppressed patients. J Clin Microbiol. 1999 Oct;37(10):3316–22.
    External Resources
  28. Garland SM, Steben M, Sings HL, James M, Lu S, Railkar R, et al. Natural history of genital warts: analysis of the placebo arm of 2 randomized phase III trials of a quadrivalent human papillomavirus (types 6, 11, 16, and 18) vaccine. J Infect Dis. 2009 Mar;199(6):805–14.
    External Resources
  29. Weaver BA, Feng Q, Holmes KK, Kiviat N, Lee SK, Meyer C, et al. Evaluation of genital sites and sampling techniques for detection of human papillomavirus DNA in men. J Infect Dis. 2004 Feb;189(4):677–85.
    External Resources
  30. Nielson CM, Flores R, Harris RB, Abrahamsen M, Papenfuss MR, Dunne EF, et al. Human papillomavirus prevalence and type distribution in male anogenital sites and semen. Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1107–14.
    External Resources
  31. Wiley DJ, Elashoff D, Masongsong EV, Harper DM, Gylys KH, Silverberg MJ, et al. Smoking enhances risk for new external genital warts in men. Int J Environ Res Public Health. 2009 Mar;6(3):1215–34.
    External Resources
  32. Liu F, Hang D, Deng Q, Liu M, Xi L, He Z, et al. Concurrence of oral and genital human papillomavirus infection in healthy men: a population-based cross-sectional study in rural China. Sci Rep. 2015 Oct;5(1):15637.
    External Resources
  33. Schabath MB, Thompson ZJ, Egan KM, Torres BN, Nguyen A, Papenfuss MR, et al. Alcohol consumption and prevalence of human papillomavirus (HPV) infection among US men in the HPV in Men (HIM) study. Sex Transm Infect. 2015 Feb;91(1):61–7.
    External Resources
  34. Kaderli R, Schnüriger B, Brügger LE. The impact of smoking on HPV infection and the development of anogenital warts. Int J Colorectal Dis. 2014 Aug;29(8):899–908.
    External Resources
  35. Anic GM, Lee JH, Villa LL, Lazcano-Ponce E, Gage C, José C Silva R, et al. Risk factors for incident condyloma in a multinational cohort of men: the HIM study. J Infect Dis. 2012 Mar;205(5):789–93.
    External Resources
  36. Tamer E, Çakmak SK, İlhan MN, Artüz F. Demographic characteristics and risk factors in Turkish patients with anogenital warts. J Infect Public Health. 2016 Sep-Oct;9(5):661–6.
    External Resources
  37. Shiely F, Hayes K, Horgan M. Comparison of risk factors for prevalent sexually transmitted infections based on attendees at two genitourinary medicine clinics in Ireland. Int J STD AIDS. 2014 Jan;25(1):29–39.
    External Resources
  38. Robbins CS, Dawe DE, Goncharova SI, Pouladi MA, Drannik AG, Swirski FK, et al. Cigarette smoke decreases pulmonary dendritic cells and impacts antiviral immune responsiveness. Am J Respir Cell Mol Biol. 2004 Feb;30(2):202–11.
    External Resources
  39. Szabo G. Alcohol’s contribution to compromised immunity. Alcohol Health Res World. 1997;21(1):30–41.
    External Resources
  40. Díaz LE, Montero A, González-Gross M, Vallejo AI, Romeo J, Marcos A. Influence of alcohol consumption on immunological status: a review. Eur J Clin Nutr. 2002 Aug;56(S3 Suppl 3):S50–3.
    External Resources
  41. Jayasinghe Y, Garland SM. Genital warts in children: what do they mean? Arch Dis Child. 2006 Aug;91(8):696–700.
    External Resources
  42. Rombaldi RL, Serafini EP, Mandelli J, Zimmermann E, Losquiavo KP. Perinatal transmission of human papilomavirus DNA. Virol J. 2009 Jun;6(1):83.
    External Resources
  43. Smith EM, Ritchie JM, Yankowitz J, Swarnavel S, Wang D, Haugen TH, et al. Human papillomavirus prevalence and types in newborns and parents: concordance and modes of transmission. Sex Transm Dis. 2004 Jan;31(1):57–62.
    External Resources
  44. Fredericks BD, Balkin A, Daniel HW, Schonrock J, Ward B, Frazer IH. Transmission of human papillomaviruses from mother to child. Aust N Z J Obstet Gynaecol. 1993 Feb;33(1):30–2.
    External Resources
  45. Gungor A, Cincik H, Baloglu H, Cekin E, Dogru S, Dursun E. Human papilloma virus prevalence in laryngeal squamous cell carcinoma. J Laryngol Otol. 2007 Aug;121(8):772–4.
    External Resources
  46. Corbitt G, Zarod AP, Arrand JR, Longson M, Farrington WT. Human papillomavirus (HPV) genotypes associated with laryngeal papilloma. J Clin Pathol. 1988 Mar;41(3):284–8.
    External Resources
  47. Chansaenroj J, Theamboonlers A, Junyangdikul P, Supiyaphan P, Poovorawan Y. Whole genome analysis of human papillomavirus genotype 11 from cervix, larynx and lung. Asian Pac J Cancer Prev. 2012;13(6):2619–23.
    External Resources
  48. de Sanjose S, Quint WG, Alemany L, Geraets DT, Klaustermeier JE, Lloveras B, et al.; Retrospective International Survey and HPV Time Trends Study Group. Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study. Lancet Oncol. 2010 Nov;11(11):1048–56.
    External Resources
  49. Sturegård E, Johansson H, Ekström J, Hansson BG, Johnsson A, Gustafsson E, et al. Human papillomavirus typing in reporting of condyloma. Sex Transm Dis. 2013 Feb;40(2):123–9.
  50. Ball SL, Winder DM, Vaughan K, Hanna N, Levy J, Sterling JC, et al. Analyses of human papillomavirus genotypes and viral loads in anogenital warts. J Med Virol. 2011 Aug;83(8):1345–50.
  51. Kwon T, Moon KH, Yang SH, Roh MC, Lee SH, Kim JW, et al. Multiple human papillomavirus infection is associated with high-risk infection in male genital warts in Ulsan, Korea. J Korean Med Sci. 2016 Mar;31(3):371–5.
  52. Tachezy R, Smahelova J, Salakova M, Arbyn M, Rob L, Skapa P, et al. Human papillomavirus genotype distribution in Czech women and men with diseases etiologically linked to HPV. PLoS One. 2011;6(7):e21913.
  53. Kofoed K, Sand C, Forslund O, Madsen K. Prevalence of human papillomavirus in anal and oral sites among patients with genital warts. Acta Derm Venereol. 2014 Mar;94(2):207–11.
  54. Greer CE, Wheeler CM, Ladner MB, Beutner K, Coyne MY, Liang H, et al. Human papillomavirus (HPV) type distribution and serological response to HPV type 6 virus-like particles in patients with genital warts. J Clin Microbiol. 1995 Aug;33(8):2058–63.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 12, 2018
Accepted: January 24, 2019
Published online: March 22, 2019
Issue release date: April 2019

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 2

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: https://www.karger.com/INT

Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Article Tools
Article Details

2018, Vol.61, No. 5

April 2019

Article

Recommend This
Open Access Gateway
TOP