Pediatric Neurosurgery

Original Paper

Pediatric Brainstem Gliomas: A Retrospective Study of 180 Patients from the SEER Database

Khalid S.I.a · Kelly R.b · Adogwa O.a · Carlton A.c · Tam E.d · Naqvi S.e · Kushkuley J.f · Ahmad S.a · Woodward J.a · Khanna R.a · Davison M.a · Munoz L.a · Byrne R.a

Author affiliations

aDepartment of Neurosurgery, Rush University Medical Center, Chicago, IL, USA
bGeorgetown University School of Medicine, Washington, DC, USA
cChicago Medical School, Rosalind Franklin University, North Chicago, IL, USA
dDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA
eCollege of Arts and Sciences, Emory University, Atlanta, GA, USA
fDepartment of PA Studies, MGH Institute of Health Professions, Charlestown, MA, USA

Keywords: Pediatric patientsBrainstemGliomaNeuro-oncology

Related Articles for ""
Pediatr Neurosurg 2019;54:151–164
https://doi.org/10.1159/000497440

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 17, 2018
Accepted: February 03, 2019
Published online: April 04, 2019
Issue release date: July 2019

Number of Print Pages: 14
Number of Figures: 5
Number of Tables: 2

ISSN: 1016-2291 (Print)
eISSN: 1423-0305 (Online)

For additional information: https://www.karger.com/PNE

Abstract

Background/Aims: Large population-based studies are needed to assess the epidemiology and survival risk factors associated with pediatric brainstem gliomas. This retrospective study explores factors that may influence survival in this population. Methods: Utilizing the SEER database, the authors retrospectively assessed survival in histologically confirmed brainstem gliomas in patients aged 17 and younger. Survival was described with Kaplan-Meyer curves and multivariate regression analysis. Results: This analysis of 180 cases showed that age (hazard ratio [HR] 1.04, 95% CI 0.96–1.14, p = 0.34), non-white race (HR 1.00, 95% CI 0.35–2.85 p > 0.99), distant or invasive extension of the tumor (HR 0.4, 95% CI 0.08–2.53, p = 0.37), and radiation therapy (HR 1.27, 95% CI 0.52–3.11, p = 0.61) were not associated with decreased survival. High-grade tumor status (HR 8.64, 95% CI 3.49–21.41, p < 0.001) was associated with decreased survival. Partial resection (HR 0.11, 95% CI 0.04–0.30, p < 0.001) and gross-total resection (HR 0.03, 95% CI 0.01–0.14, p < 0.001) were associated with improved survival. Conclusions: High-grade brainstem gliomas have a worse prognosis. Early diagnosis and surgery appear to be associated with improved survival, while the role of radiation is unclear.

© 2019 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 17, 2018
Accepted: February 03, 2019
Published online: April 04, 2019
Issue release date: July 2019

Number of Print Pages: 14
Number of Figures: 5
Number of Tables: 2

ISSN: 1016-2291 (Print)
eISSN: 1423-0305 (Online)

For additional information: https://www.karger.com/PNE

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