Dementia and Geriatric Cognitive Disorders

Research Article

Soluble Intercellular Adhesion Molecule-1 (sICAM-1) as a Biomarker of Vascular Cognitive Impairment in Older Adults

Gregory M.A.a · Manuel-Apolinar L.b · Sánchez-Garcia S.c · Villa Romero A.R.d · de Jesús Iuit Rivera J.e · Basurto Acevedo L.b · Grijalva-Otero I.f · Cuadros-Moreno J.g · Garcia-de la Torre P.f · Guerrero Cantera J.h · Garcia Dominguez J.A.d · Martínez Gallardo S.e · Vega Garcia S.b · Mejía Alonso L.A.e · Sánchez-Arenas R.d

Author affiliations

aDepartment of Rehabilitation Science, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
bEndocrine Research Unit, Centro Medico Nacional, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico
cResearch Unit in Epidemiology and Health Services. Aging Area, Centro Médico Nacional, IMSS, Mexico City, Mexico
dResearch Division, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico
eSpecialties Hospital “Dr. Bernardo Sepúlveda Gutiérrez” Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico
fMedical Research Unit in Neurological Diseases, Centro Médico Nacional, IMSS, Mexico City, Mexico
gInnovation Division. Health Education Coordination, IMSS, Mexico City, Mexico
hGeneral Hospital Zone 71, IMSS, Mexico City, Mexico

Keywords: Aging and cognitionBlood biomarkersVascular cognitive impairmentICAM-1

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Dement Geriatr Cogn Disord 2019;47:243–253
https://doi.org/10.1159/000500068

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Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: July 30, 2018
Accepted: April 01, 2019
Published online: August 13, 2019
Issue release date: October 2019

Number of Print Pages: 11
Number of Figures: 1
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

Abstract

Background: Endothelial dysfunction and subsequent inflammation contribute to the development of vascular cognitive impairment (VCI). Soluble intercellular adhesion molecule-1 (sICAM-1) is upregulated in endothelial dysfunction and promotes an inflammatory response; however, the relationship between sICAM-1 and VCI remains equivocal. Objective: To determine whether sICAM-1 contributes to the prediction of VCI. Methods: Community-dwelling older adults (n = 172) from the “Cohort of Obesity, Sarcopenia and Frailty of Older Mexican Adults” (COSFOMA) study were identified as VCI or controls using standard neuropsychological evaluations and neuroimaging. sICAM-1 was quantified using ELISA, and multivariate logistic regression determined the association between sICAM-1 and VCI. Results: A total of 31 VCI cases were identified. sICAM-1 was higher in VCI (VCI: 450.7 [241.6] ng/mL vs. controls: 296.9 [140.9] ng/mL). sICAM-1 concentrations above the 90th percentile (464.1 ng/mL) were associated with VCI group membership in all models (OR: 6.9, 95% CI: 1.1–42.2). The final saturated model explained 64% of the variance in VCI group membership. Conclusion: High concentrations of sICAM-1 are independently associated with VCI group membership. Efforts to further characterize the relationship between indices of endothelial dysfunction and pathological changes to the aging brain should be further pursued.

© 2019 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: July 30, 2018
Accepted: April 01, 2019
Published online: August 13, 2019
Issue release date: October 2019

Number of Print Pages: 11
Number of Figures: 1
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

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2019, Vol.47, No. 4-6

October 2019

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Michael A. Gregory and Leticia Manuel-Apolinar contributed equally to this work.

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