Digestion

Research Article

Influence of Living Environment during Childhood on Helicobacter pylori Infection in Japanese Young Adults

Ueno T.a · Suzuki H.b · Hirose M.c · Shida T.d · Ikezawa K.e · Matsui H.b · Mizokami Y.b · Yanaka A.f

Author affiliations

aDepartment of Gastroenterology, Tsukuba Central Hospital, Ushiku, Japan
bDepartment of Gastroenterology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
cDepartment of Gastroenterology, Tsuchiura Clinical Education and Training Center, University of Tsukuba Hospital, Tsuchiura, Japan
dTsukuba Preventive Medicine Research Center, University of Tsukuba Hospital, Tsukuba, Japan
eDivision of Gastroenterology, Tsukuba Memorial Hospital, Tsukuba, Japan
fDepartment of Gastroenterology, Hitachi Medical Education and Research Center, University of Tsukuba Hospital, Hitachi, Japan

Keywords: Helicobacter pyloriInfection routeHygienic environmentGrandparentResidential area

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Digestion 2020;101:779–784
https://doi.org/10.1159/000502574

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Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: May 28, 2019
Accepted: August 06, 2019
Published online: September 24, 2019
Issue release date: November 2020

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: https://www.karger.com/DIG

Abstract

Introduction: Helicobacter pylori infection is usually established during childhood, for which certain responsible environmental factors have been identified. However, the details of the infection routes remain unclear. Objective: To determine the relation between H. pylori infection statuses and living environment of Japanese young adult. Methods: The subjects were 449 healthy young adult medical students of Tsukuba University (299 men and 150 women, mean age: 22.8 years). The H. pylori infection statuses were investigated using the rapid urease test or urine antibody. Questionnaires regarding sanitary conditions including usage of pit toilet or well water and experience of living with one’s grandparents during childhood were surveyed. Each item was compared between the H. pylori-positive and -negative groups. Results: Among all participants, 33 (7.3%) were H. pylori-positive. The usage rates of pit toilets were 12.1 and 3.1% for the H. pylori-positive and -negative groups respectively (p = 0.03; OR 4.35, 95% CI 1.33–14.22). The usage rates of well water were 24.2 and 13.7% for the H. pylori-positive and -negative groups respectively (p = 0.07; OR 2.12, 95% CI 0.91–4.98). The proportion of participants with a history of living with their grandparents was significantly greater in the H. pylori-positive group (46.7%) than in the -negative group (20.9%; p = 0.03; OR 3.28, 95% CI 1.13–9.54). Only a history of living with one’s grandparents during childhood showed statistical significance in the multivariate regression analysis (p = 0.04; OR 3.20, 95% CI 1.08–9.49). Conclusions: These results suggest that H. pylori infection is more strongly related to living with one’s grandparents than living in a hygienic environment.

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Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: May 28, 2019
Accepted: August 06, 2019
Published online: September 24, 2019
Issue release date: November 2020

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: https://www.karger.com/DIG

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2020, Vol.101, No. 6

November 2020

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