Pathobiology

Original Paper

Free Access

Human Papillomavirus Epitope Mimicry and Autoimmunity: The Molecular Truth of Peptide Sharing

Kanduc D.a · Shoenfeld Y.b,c

Author affiliations

aDepartment of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari, Bari, Italy
bZabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Affiliated to Tel-Aviv, University School of Medicine, Ramat Gan, Israel
cI.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian, Federation, Sechenov University, Moscow, Russian Federation

Corresponding Author

Darja Kanduc

Department of Biosciences, Biotechnologies and Biopharmaceutics

University of Bari

Via Orabona 4, IT–70125 Bari (Italy)

E-Mail dkanduc@gmail.com

Keywords: Human papillomavirus L1 epitopesPeptide sharingCross-reactivityMolecular mimicryAutoimmunityNegative selection

Related Articles for ""
Pathobiology 2019;86:285–295
https://doi.org/10.1159/000502889

Abstract

Objective: To define the cross-reactivity potential and the consequent autoimmunity intrinsic to viral versus human peptide sharing. Methods: Using human papillomavirus (HPV) infection/active immunization as a research model, the experimentally validated HPV L1 epitopes catalogued at the Immune Epitope DataBase were analyzed for peptide sharing with the human proteome. Results: The final data show that the totality of the immunoreactive HPV L1 epi­topes is mostly composed by peptides present in human proteins. Conclusions: Immunologically, the high extent of peptide sharing between the HPV L1 epitopes and human proteins invites to revise the concept of the negative selection of self-reactive lymphocytes. Pathologically, the data highlight a cross-reactive potential for a spectrum of autoimmune diseases that includes ovarian failure, systemic lupus erythematosus (SLE), breast cancer and sudden death, among others. Therapeutically, analyzing already validated immunoreactive epitopes filters out the peptide sharing possibly exempt of self-reactivity, defines the effective potential for pathologic autoimmunity, and allows singling out peptide epitopes for safe immunotherapeutic protocols.

© 2019 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 07, 2019
Accepted: August 22, 2019
Published online: October 08, 2019
Issue release date: December 2019

Number of Print Pages: 11
Number of Figures: 2
Number of Tables: 5

ISSN: 1015-2008 (Print)
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