Ophthalmic Research

Research Article

Associations between Blood Cell Profiles and Primary Open-Angle Glaucoma: A Retrospective Case-Control Study

Tang B.a · Li S.a · Han J.a · Cao W.a,b · Sun X.b,c,d,e

Author affiliations

aDepartment of Clinical Laboratory, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China
bDepartment of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China
cState Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China
dKey Laboratory of Myopia, Ministry of Health (Fudan University), Shanghai, China
eShanghai Key Laboratory of Visual Impairment and Restoration (Fudan University), Shanghai, China

Keywords: Primary open-angle glaucomaInflammationNeutrophil-to-lymphocyte ratioPlatelet-to-lymphocyte ratioSystemic immune inflammation index

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Ophthalmic Res 2020;63:413–422
https://doi.org/10.1159/000504450

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Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: June 25, 2019
Accepted: October 26, 2019
Published online: February 04, 2020
Issue release date: July 2020

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 7

ISSN: 0030-3747 (Print)
eISSN: 1423-0259 (Online)

For additional information: https://www.karger.com/ORE

Abstract

Purpose: We aimed to evaluate whether the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune inflammation index (SII) were associated with primary open-angle glaucoma (POAG). Materials and Methods: This retrospective case-control study included 240 patients with POAG and 300 age- and sex-matched control subjects. Complete ophthalmological examination and blood count measurements were performed for all subjects. Results: The values of NLR, PLR, and SII in the POAG group were significantly increased compared with the control group (p < 0.001; p = 0.012; p < 0.001). However, the LMR value was lower in the POAG patients than in the control group (p < 0.001). When we divided the subjects into different age and gender subgroups, the NLR and SII values in the POAG patients were always higher than those in the control group. In the comparison of laboratory parameters in POAG subjects stratified according to severity, we also found that NLR and SII increased with the severity. The receiver operating characteristic (ROC) analysis revealed that the areas under the ROC curve of NLR, PLR, LMR, and SII to predict patients with POAG were found to be 0.627, 0.569, 0.382, and 0.986, respectively. The best cutoff point of NLR was 1.998 with a sensitivity of 59.8% and a specificity of 63.0%, and the SII was 947.365 with a sensitivity of 95.4% and a specificity of 95.7%. Multivariable logistic regression analysis showed that NLR was positively associated with mean deviation; moreover, NLR and SII were independent indicators correlated with POAG (OR 1.502; 95% CI 1.227–1.839; p < 0.001; OR 1.02; 95% CI 1.009–1.021; p < 0.001). Conclusion: We speculated that elevated NLR and SII might serve as readily available inflammatory predictors in POAG patients.

© 2020 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: June 25, 2019
Accepted: October 26, 2019
Published online: February 04, 2020
Issue release date: July 2020

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 7

ISSN: 0030-3747 (Print)
eISSN: 1423-0259 (Online)

For additional information: https://www.karger.com/ORE

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