Milk, Mucosal Immunity and the Microbiome: Impact on the Neonate
94th Nestlé Nutrition Institute workshop, Lausanne, September 2019
Editor(s): Ogra, Pearay L. (Buffalo, NY)Walker, W. Allan (Boston, MA)
Lönnerdal, Bo (Davis, CA)
Protective Factors in Human Milk
Human Milk Oligosaccharides: Structure and FunctionsBode L.Division of Neonatology and Division of Gastroenterology and Nutrition, Department of Pediatrics, Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), University of California, La Jolla, CA, USA
|
|
Log in to MyKarger to check if you already have access to this content.
KAB
Buy a Karger Article Bundle (KAB) and profit from a discount!
If you would like to redeem your KAB credit, please log in.
Save over 20% compared to the individual article price.
Article / Publication Details
Received: November 21, 2019
Accepted: December 10, 2019
Published online: March 11, 2020
Cover Date: 2019
Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 0
ISBN: 978-3-318-06684-5 (Print)
eISBN: 978-3-318-06685-2 (Online)
Abstract
Oligosaccharides are a group of complex glycans that are present in the milk of most mammals. However, human milk is unique as the concentrations of human milk oligosaccharides (HMOs) are much higher than those of other mammals, and their structural composition is more complex and varies between women. These observations prompt several questions: (i) Why are humans unique when it comes to milk oligosaccharides? (ii) Which maternal genetic and environmental factors drive the interindividual variation in HMO composition? (iii) What are the short- and long-term health benefits for the infant – and potentially also the mother? The combination of genome-wide association studies, milk transcriptomics, in vitro gene editing, and in silico pathway modeling allows us to reconstruct HMO biosynthetic pathways. Using new data mining approaches and leveraging samples and metadata from large mother-infant cohorts enable us to identify associations between HMO composition and infant and maternal health outcomes. Suitable preclinical models and clinical intervention studies allow us to corroborate the established associations for causal relationships and test for in vivo efficacy in humans. Knowledge generated from these different approaches will help us establish true structure-function relationships and provide the rigorous evidence required to improve infant health and development.
© 2020 Nestlé Nutrition Institute, Switzerland/S. Karger AG, Basel
Related Articles:
References
-
Bode L: Human milk oligosaccharides: every baby needs a sugar mama. Glycobiology 2012;22:1147–1162.
-
Jantscher-Krenn E, Bode L: Structure-function relationships of human milk oligosaccharides. Adv Nutr 2012;3:383S–391S.
-
Azad MB, Robertson B, Atakora F, et al: Human milk oligosaccharide concentrations are associated with multiple fixed and modifiable maternal characteristics, environmental factors and feeding practices. J Nutr 2018;148:1733–1742.
-
Kumazaki T, Yoshida A: Biochemical evidence that secretor gene, Se, is a structural gene encoding a specific fucosyltransferase. Proc Natl Acad Sci USA 1984;81:4193–4197.
-
Stahl B, Thurl S, Henker J, et al: Detection of four human milk groups with respect to Lewis-blood-group-dependent oligosaccharides by serologic and chromatographic analysis. Adv Exp Med Biol 2001;501:299–306.
-
Johnson PH, Watkins WM: Purification of the Lewis blood-group gene associated α-3/4-fucosyltransferase from human milk: an enzyme transferring fucose primarily to type 1 and lactose-based oligosaccharide chains. Glycoconj J 1992;9:241–249.
-
Seppo AE, Kukkonen AK, Kuitunen M, et al: Association of maternal probiotic supplementation with human milk oligosaccharide composition. JAMA Pediatr 2019;173:286–288.
-
Ruhaak LR, Stroble C, Underwood MA, et al: Detection of milk oligosaccharides in plasma of infants. Anal Bioanal Chem 2014;406:5775–5784.
-
Goehring KC, Kennedy AD, Prieto PA, et al: Direct evidence for the presence of human milk oligosaccharides in the circulation of breastfed infants. PLoS One 2014;9:e101692.
-
Rudloff S, Obermeier S, Borsch C, et al: Incorporation of orally applied (13)C-galactose into milk lactose and oligosaccharides. Glycobiology 2006;16:477–487.
-
Dotz V, Rudloff S, Blank D, et al: 13C-labeled oligosaccharides in breastfed infants’ urine: individual-, structure- and time-dependent differences in the excretion. Glycobiology 2014;24:185–194.
-
German JB, Freeman SL, Lebrilla CB, et al: Human milk oligosaccharides: evolution, structures and bioselectivity as substrates for intestinal bacteria. Nestlé Nutr Workshop Ser Pediatr Program 2008;62:205–218; discussion 218–222.
-
Oftedahl OT: The evolution of milk secretion and its ancient origins. Animal 2012;6:355–368.
-
Lin AE, Autran CA, Szyszka A, et al: Human milk oligosaccharides inhibit growth of group B streptococcus. J Biol Chem 2017;292:11243–11249.
-
Ruiz-Palacios GM, Cervantes LE, Ramos P, et al:
Campylobacter jejuni binds intestinal H (O) antigen (Fucα1,2Galβ1, 4GlcNAc), and fucosyloligosaccharides of human milk inhibit its binding and infection. J Biol Chem 2003;278:14112–14120. -
Morrow AL, Ruiz-Palacios GM, Altaye M, et al: Human milk oligosaccharides are associated with protection against diarrhea in breast-fed infants. J Pediatr 2004;145:297–303.
-
Manthey CF, Autran CA, Eckmann L, Bode L: Human milk oligosaccharides protect against enteropathogenic
E. coli attachment in vitro and colonization in suckling mice. J Pediatr Gastroenterol Nutr 2014;58:167–170. -
LoCascio RG, Ninonuevo MR, Freeman SL, et al: Glycoprofiling of bifidobacterial consumption of human milk oligosaccharides demonstrates strain specific, preferential consumption of small chain glycans secreted in early human lactation. J Agric Food Chem 2007;55:8914–8919.
-
Ramani S, Stewart CJ, Laucirica DR, et al: Complex interplay between human milk oligosaccharides, milk microbiome and infant gut microbiome modulates neonatal rotavirus infection. Nat Commun 2018;9:5010.
-
Alderete TL, Autran CA, Brekke BE, et al: Associations between human milk oligosaccharides and infant body composition in the first six months of life. Am J Clin Nutr 2015;102:1381–1388.
-
Larsson MW, Lind MV, Laursen RP, et al: Human milk oligosaccharide composition is associated with excessive weight gain during exclusive breastfeeding – an explorative study. Front Pediatr 2019;7:297.
-
Wise A, Robertson B, Choudhury B, et al: Infants are exposed to human milk oligosaccharides already in utero. Front Pediatr 2018;6:270.
-
Jantscher-Krenn E, Aigner J, Reiter B, et al: Evidence of human milk oligosaccharides in maternal circulation already during pregnancy – a pilot study. Am J Physiol Endocrinol Metab 2019;316:E347–E357.
-
Bode L, Contractor N, Barile D, et al: Overcoming the limited availability of human milk oligosaccharides: challenges and opportunities for research and application. Nutr Rev 2016;74:635–644.
Article / Publication Details
Received: November 21, 2019
Accepted: December 10, 2019
Published online: March 11, 2020
Cover Date: 2019
Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 0
ISBN: 978-3-318-06684-5 (Print)
eISBN: 978-3-318-06685-2 (Online)
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Get Permission
PubMed ID
