Respiration
Clinical Investigations
Airway Hyperresponsiveness and Pulmonary Function in Adult AsthmaMitsuta K. · Shimoda T. · Kawano T. · Obase Y. · Fukushima C. · Matsuse H. · Kohno S.Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
|
|
Log in to MyKarger to check if you already have access to this content.
KAB
Buy a Karger Article Bundle (KAB) and profit from a discount!
If you would like to redeem your KAB credit, please log in.
Save over 20% compared to the individual article price.
Article / Publication Details
Published online: October 26, 2001
Issue release date: September – October
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 5
ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)
For additional information: https://www.karger.com/RES
Abstract
Background: Airway hyperresponsiveness (AHR) is a very important factor in the pathogenesis of bronchial asthma. Objectives: To examine the relationship between airway obstruction and AHR in adult asthma. Methods: This study was a retrospective study in 161 adult asthmatic patients. Nonspecific AHR to methacholine was measured. We examined the correlations between AHR and pulmonary function, severity of asthma, type of asthma and age. Results: In the moderate and severe groups, peripheral airway obstruction was more aggravated compared to the mild group, and AHR was significantly more severe. Analysis of AHR by age showed that the degree of airway obstruction increased with aging, but age did not clearly correlate with airway sensitivity. Airway reactivity decreased with aging. Aspirin-induced asthma tended to be severe. In fatal asthma, central airway obstruction was significantly more severe. Although AHR in fatal asthma did not significantly differ from that in the severe group, airway sensitivity and airway reactivity tended to be increased. Conclusions: AHR is an important factor determining the severity of asthma, and airway obstruction is an important index for the prediction of death from asthma. An evaluation of the degree of AHR and airway obstruction is considered to be the first step in controlling asthma.
© 2001 S. Karger AG, Basel
Related Articles:
References
-
National Institutes of Health, National Heart, Lung, and Blood Institute: Global Initiative for Asthma. Global strategy for asthma management and prevention. NHLBI/WHO workshop report. Publication No 96–3659B, 1998.
- Dahlen B, Zetterstram O: Comparison of bronchial and peroral provocation with aspirin in aspirin-sensitive asthmatics. Eur Respir J 1990;3:527–534.
- Takishima T, Hida W, Sasaki H, et al: Direct-writing recorder of the dose-response curves of the airway to methacholine. Chest 1981;80:600–606.
- Zamel N, Leroux M, Vanderdoelen JL: Airway response to inhaled methacholine in healthy nonsmoking twins. J Appl Physiol 1984;56:936–939.
- Nieminen MM, Kaprio J, Koskenvuo M: A population-based study of bronchial asthma in adult twin pairs. Chest 1991;100:70–75.
- Hopp RJ, Bewtra A, Nair NM, et al: The effect of age on methacholine response. J Allergy Clin Immunol 1985;76:609–613.
-
Gilbert GB: Unusual idiosyncrasy to aspirin. JAMA1911;56:1262.
-
Szczeklik A, Stevenson DD: Aspirin-induced asthma: Advances in pathogenesis and management. J Allergy Clin Immunol 1999;194:5–13.
- Marquette CH, Saulnier F, Leroy O, et al: Long-term prognosis of near-fatal asthma. A 6-year follow-up study of 145 asthmatic patients who underwent mechanical ventilation for a near-fatal attack of asthma. Am Rev Resp Dis 1992;146:76–81.
- Szczeklik A, Duplaga NM: Natural history of aspirin-induced asthma. Eur Resp J 2000;16:432–436.
- Dunnill MS, Massarella GR, Anderson JA: A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis, and in emphysema. Thorax 1969;24:176–179.
- Carrol N, Elliot A, Morton A, et al: The structure of large and small airways in nonfatal and fatal asthma. Am Rev Respir Dis 1993;147:405–410.
- James AL, Pare PD, Hogg JC: The mechanics of airway narrowing in asthma. Am Rev Respir Dis 1989;139:242–246.
- Moreno RH, Hogg JC, Pare PD: Mechanisms of airway narrowing. Am Rev Respir Dis 1986;133:1171–1180.
- Wiggs BR, Moreno RH, Hogg JC, et al: A model of the mechanics of airway narrowing. J Appl Physiol 1990;69:849–860.
- Postma DS, Bleecker ER, Amelung PJ, et al: Genetic susceptibility to asthma: Bronchial hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med 1995;333:894–900.
- Van Herwerden L, Harrap SB, Wong ZYH, et al: Linkage of high-affinity IgE receptor gene with bronchial hyperreactivity, even in absence of atopy. Lancet 1995;346:1262–1265.
- Hall IP, Wheatley A, Wilding P, et al: Association of Glu 27 beta2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects. Lancet 1995;345:1213–1214.
- Turki J, Park J, Green SA, et al: Genetic polymorphisms of the beta2-adrenergic receptor in nocturnal and nonnocturnal asthma: Evidence that Gly 16 correlates with the nocturnal phenotype. J Clin Invest 1995;95:1635–1641.
Article / Publication Details
Published online: October 26, 2001
Issue release date: September – October
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 5
ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)
For additional information: https://www.karger.com/RES
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Get Permission
PubMed ID
