Serum Levels of Vascular Endothelial Growth Factor and Cavity Formation in Active Pulmonary TuberculosisAbe Y.a · Nakamura M.b · Oshika Y.b · Hatanaka H.b · Tokunaga T.b · Ohkubo Y.a · Hashizume T.a · Suzuki K.a · Fujino T.a
aDepartment of Respiratory Disease, National Sanatorium Kanagawa Hospital, Hadano, bDepartment of Pathology, Tokai University School of Medicine, Isehara, Japan
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Background: In active pulmonary tuberculosis, certain cytokines have been postulated to be related to cavity formation, although the detailed mechanism of cavity formation is not yet known. Objective: We examined the relationship between cavity formation in pulmonary tuberculosis and vascular endothelial growth factor (VEGF), which functions as an angiogenesis factor. Methods: Forty-eight patients with active pulmonary tuberculosis were divided into two groups according to cavity formation as evaluated by chest high-resolution computed tomography. We evaluated serum VEGF levels by enzyme immunoassay. Results: Group A (with cavities) was comprised of 22 patients and group B (without cavities) was comprised of 26 patients. The serum levels of VEGF were significantly higher in group B (58.733 ± 21.612 pg/ml) than those in normal individuals (8.739 ± 3.656 pg/ml) and in group A (13.053 ± 8.670 pg/ml) (Mann-Whitney U test, p = 0.0149 and p = 0.0481, respectively). Serum levels of interleukin-8 and tumor necrosis factor-α were not significantly different between the two groups. Conclusion: These findings suggested that increased serum VEGF levels subdue cavity formation in active pulmonary tuberculosis.
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