Complementary Medicine Research

Research Article / Originalarbeit

The Efficacy of Topical Basil Essential Oil on Relieving Migraine Headaches: A Randomized Triple-Blind Study

Ahmadifard M.a · Yarahmadi S.b,f · Ardalan A.c · Ebrahimzadeh F.d · Bahrami P.e · Sheikhi E.f

Author affiliations

aYoung Researchers Club, Khorramabad Branch, Islamic Azad University, Khorramabad, Iran
bDepartment of Critical Care Nursing, Faculty of Nursing and Midwifery, Lorestan University of Medical Sciences, Khorramabad, Iran
cProvidence Saint Joseph Medical Center, Burbank, CA, USA
dDepartment of Biostatistics, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran
eDepartment of Neurology, Lorestan University of Medical Sciences, Khorramabad, Iran
fSocial Determinants of Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

Keywords: Complementary medicineHeadacheHerbal medicinesMigraineOcimum basilicum

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Complement Med Res 2020;27:310–318
https://doi.org/10.1159/000506349

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Article / Publication Details

First-Page Preview
Abstract of Research Article / Originalarbeit

Received: August 20, 2019
Accepted: February 03, 2020
Published online: March 10, 2020
Issue release date: October 2020

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 3

ISSN: 2504-2092 (Print)
eISSN: 2504-2106 (Online)

For additional information: https://www.karger.com/CMR

Abstract

Objective: Complementary therapies have been increasingly used for the prevention and treatment of migraine so that there is a need for studies in this setting. This study sought to determine the effects of basil essential oil on the severity and frequency of migraine attack headaches. Methods: A triple-blind clinical trial study was performed on 144 patients diagnosed with migraine. Patients were randomly allocated by a stratified method to four groups of 36 titled basil essential oil 2, 4, 6%, and placebo groups. Medications were used topically every 8 h for 3 successive months. In addition, each individual received 325 mg of acetaminophen every 12 h. The severity and frequency of migraine attacks were measured prior to the study, at weeks 2, 4, 8, and 12. The visual analog scale was used to measure pain intensity. The marginal model and generalized estimation equations were used to compare changes in the intensity and frequency of pain over time. Results: The interaction of the dose and time factors was significant on both pain intensity (p < 0.001) and frequency of attack (p < 0.001). The odds ratio of higher pain intensity and rate ratio of higher frequency of attack in the intervention groups compared to the placebo group were decreased over the study time. Conclusion: Time lapse and higher doses of basil essential oil would reduce both the intensity and frequency of migraine attacks.

© 2020 S. Karger AG, Basel

Wirksamkeit von topischem ätherischem Basilikumöl zur Reduktion von Migränekopfschmerzen: eine randomisierte Studie

Schlüsselwörter

Komplementärmedizin · Kopfschmerzen · Pflanzliche Arzneimittel · Migräne · Ocimum basilicum ·

Zusammenfassung

Ziel: Komplementäre Behandlungsansätze finden zuneh­mend Anwendung in der Prävention und Therapie der Migräne, daher bedarf es auch wissenschaftlicher Studien zu diesem Setting. Das Ziel dieser Studie war es, die Auswirkungen von ätherischem Basilikumöl auf die Schwere und Häufigkeit von Migräneattacken und damit einhergehenden Kopfschmerzen zu untersuchen. Methoden: Es handelte sich um eine dreifach verblindete klinische Studie, an der 144 Patienten mit diagnostizierter Migräne teilnahmen. Nach Randomisierung und Stratifizierung wurden die Patienten in vier Gruppen zu je 36 Patienten aufgeteilt: je eine mit essenziellem Basilikumöl 2, 4 und 6% behandelte Gruppe und eine Placebogruppe. Das ­Arzneimittel wurde drei aufeinanderfolgende Monate lang alle acht Stunden topisch angewendet. Zusätzlich erhielt jeder Patient alle zwölf Stunden 325 mg Acetaminophen. Die Erhebung der Schwere und Häufigkeit von Migräneattacken erfolgte vor Studienbeginn und nach Woche 2, 4, 8 und 12. Die Schmerzstärke wurde auf einer visuellen ­Analogskala gemessen. Vergleiche erfolgten anhand der Veränderung der Schwere und Häufigkeit der Schmerzen im Zeitverlauf laut marginalen Modellen und verallgemeinerten Schätzgleichungen. Ergebnisse: Die Wechselwirkungen zwischen den Faktoren Dosis und Zeit waren signifikant, sowohl im Hinblick auf die Stärke der Schmerzen (p < 0,001) als auch auf die Häufigkeit der ­Attacken (p < 0,001). Die Odds Ratio für eine höhere Schmerzstärke und die Rate Ratio für eine höhere Anfallshäufigkeit in den Interventionsgruppen im Vergleich zur Placebogruppe nahmen im zeitlichen Verlauf der Studie ab. Schlussfolgerung: Zeitverlauf und höhere Dosierung des ätheri­schen Basilikumöls scheinen die Stärke und Häufigkeit von Migräneattacken zu reduzieren.



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Article / Publication Details

First-Page Preview
Abstract of Research Article / Originalarbeit

Received: August 20, 2019
Accepted: February 03, 2020
Published online: March 10, 2020
Issue release date: October 2020

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 3

ISSN: 2504-2092 (Print)
eISSN: 2504-2106 (Online)

For additional information: https://www.karger.com/CMR

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2020, Vol.27, No. 5

October 2020

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