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Original Paper

Switch-Over from Tolcapone to Entacapone in Severe Parkinson’s Disease Patients

Onofrj M. · Thomas A. · Iacono D. · Di Iorio A. · Bonanni L.

Author affiliations

Department of Oncology and Neuroscience, Neurophysiopathology, University ‘G. D’Annunzio’, Pescara, Italy

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Eur Neurol 2001;46:11–16

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: July 12, 2001
Issue release date: July 2001

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE

Abstract

Forty patients affected by severe Parkinson’s disease (PD) were treated with tolcapone as an adjunctive therapy to L-DOPA, for 3–7 months, until this drug was discontinued because of side-effects (2 diarrhoea, one of them with orthostatic hypotension, 2 increments of liver enzymes) or because of mandatory indications of the European drugs authority. All patients, after 3–6 months of L-DOPA therapy adjustments, received entacapone for 3 months again followed by withdrawal. L-DOPA daily dosage was significantly reduced by tolcapone and entacapone (p = 0.01 and 0.05). ‘On’ time was increased by 15% during tolcapone treatment (p < 0.05), and by 8% during entacapone treatment. ‘Off’ time was decreased by 16% during tolcapone and by 7% during entacapone treatment. Entacapone was withdrawn in the same patient who experienced diarrhoea and orthostatic hypotension during tolcapone because of recurrence of side-effects, in 6 patients because of increment of dyskinesias (with hallucinations) and in 1 patients because of rhythmic, jerking myoclonus.

© 2001 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: July 12, 2001
Issue release date: July 2001

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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