Annals of Nutrition and Metabolism

Human Nutrition: Research Article

Dietary Vitamin E Intake Was Inversely Associated with Hyperuricemia in US Adults: NHANES 2009–2014

Zhang L.a · Shi X.b · Yu J.a · Zhang P.a · Ma P.c · Sun Y.a

Author affiliations

aDepartment of Nutrition and Food Hygiene, School of Public Health, Qingdao University, Qingdao, China
bDepartment of Microorganism Test, Qingdao Municipal Center for Disease Control and Prevention, Qingdao, China
cDepartment of Anesthesiology, The Third People’s Hospital of Qingdao, Qingdao, China

Keywords: HyperuricemiaDietary vitamin E intakeUric acidNational Health and Nutrition Examination SurveyCross-sectional study

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Ann Nutr Metab 2020;76:354–360
https://doi.org/10.1159/000509628

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Article / Publication Details

First-Page Preview
Abstract of Human Nutrition: Research Article

Received: October 09, 2019
Accepted: June 23, 2020
Published online: September 21, 2020
Issue release date: January 2021

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: https://www.karger.com/ANM

Abstract

Introduction: Current evidence on the association between dietary vitamin E intake and hyperuricemia risk is limited and conflicting. Objective: The aim of the study was to assess the association of dietary vitamin E intake with hyperuricemia in US adults. Methods: We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey, 2009–2014. Dietary vitamin E intake was evaluated through two 24-h dietary recall interviews. Logistic regression and restricted cubic spline models were used to examine the association between dietary vitamin E intake and hyperuricemia. Results: Overall, 12,869 participants were included. The prevalence of hyperuricemia was 19.35%. After adjustment for age, gender, BMI, race, educational level, smoking status, alcohol consumption, physical activity, total daily energy intake, total cholesterol, protein intake, glomerular filtration rate, serum Cr, use of uric acid drugs, and drug abuse, the odds ratio (95% confidence interval) of hyperuricemia for the highest tertile of dietary vitamin E intake was 0.77 (0.63–0.96) compared with that of the lowest tertile. In men, dietary vitamin E intake and hyperuricemia were negatively correlated. In stratified analyses by age (20–39, 40–59, and ≥60 years), dietary vitamin E intake was inversely associated with hyperuricemia only among participants aged ≥60 years. Dose-response analyses showed that dietary vitamin E intake was inversely associated with hyperuricemia in a nonlinear manner. Conclusion: Dietary vitamin E intake was negatively correlated with hyperuricemia in US adults, especially among males and participants aged ≥60 years.

© 2020 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Human Nutrition: Research Article

Received: October 09, 2019
Accepted: June 23, 2020
Published online: September 21, 2020
Issue release date: January 2021

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: https://www.karger.com/ANM

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2020, Vol.76, No. 5

January 2021

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