Digestion

Research Article

Lipoprotein and Metabolic Profiles Indicate Similar Cardiovascular Risk of Liver Steatosis and NASH

Gottlieb A.a,b · Leven A.-S.c · Sowa J.-P.b,d · Borucki K.e · Link A.b · Yilmaz E.f · Aygen S.f · Canbay A.d · Porsch-Özcürümez M.d

Author affiliations

aDepartment of Physiology, Johns Hopkins School of Medicine, Baltimore, MD, USA
bDepartment of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke University Magdeburg, Magdeburg, Germany
cDepartment for General- and Visceral Surgery, Alfried Krupp Hospital, Essen, Germany
dDepartment of Internal Medicine, University Hospital Knappschaftskrankenhaus Bochum, University Bochum, Bochum, Germany
eInstitute for Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke University Magdeburg, Magdeburg, Germany
fINFAI GmbH, Cologne, Germany

Keywords: Nonalcoholic fatty liver diseaseCholesterolNMR analysisAmino acidsNoninvasive test

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Digestion 2021;102:671–681
https://doi.org/10.1159/000510600

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Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: May 05, 2020
Accepted: July 29, 2020
Published online: October 20, 2020
Issue release date: September 2021

Number of Print Pages: 11
Number of Figures: 5
Number of Tables: 1

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: https://www.karger.com/DIG

Abstract

Background and Aim: Nonalcoholic fatty liver disease (NAFLD) affects about 25% of the global population, with no reliable noninvasive tests to diagnose nonalcoholic steatohepatitis (NASH) and to differentiate between NASH and nonalcoholic fatty liver (NAFL) (steatosis alone). It is unclear if NAFL and NASH differ in cardiovascular risk for patients. Here, we compared obese NAFLD patients with a healthy cohort to test whether cholesterol compounds could represent potential noninvasive markers and to estimate associated risks. Method: Serum samples of 46 patients with histologically confirmed NAFLD (17 NAFL, 29 NASH) who underwent bariatric surgery were compared to 32 (9 males, 21 females) healthy controls (HCs). We analyzed epidemiological data, liver enzymes, cholesterol and lipid profile, and amino acids. The latter were analyzed by nuclear magnetic resonance spectroscopy. Results: Total serum and high-density lipoprotein (HDL) cholesterol were significantly lower in the NAFLD group than in HCs, with a stronger reduction in NASH. Similar observations were made for sub-specification of HDL-p, HDL-s, SHDL-p, and LHDL-p cholesterols. Low-density lipoprotein (LDL)-s and LLDL-p cholesterol were significantly reduced in NAFLD groups. Interestingly, SLDL-p cholesterol was significantly higher in the NAFL group with a stronger elevation in NASH than in HCs. The amino acids alanine, leucin, and isoleucine were significantly higher in the NAFL and NASH groups than in HCs. Conclusion: We show in this study that cholesterol profiles, apolipoproteins, and amino acids could function as a potential noninvasive test to screen for NAFLD or even NASH in larger populations. However, few differences in cholesterol profiles were identified between the NAFL and NASH groups, indicating similar cardiovascular risk profiles.

© 2020 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: May 05, 2020
Accepted: July 29, 2020
Published online: October 20, 2020
Issue release date: September 2021

Number of Print Pages: 11
Number of Figures: 5
Number of Tables: 1

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: https://www.karger.com/DIG

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