Gynecologic and Obstetric Investigation

Original Article

Diagnostic Relevance of Ferrokinetic Laboratory Markers in Anemic Pregnant Women

Aringazina R. · Zharmakhanova G. · Kurmanalina G. · Bekkuzhin A. · Kurmanalin B.

Author affiliations

Non-Commercial Joint-Stock Society, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan

Keywords: Iron deficiency conditionsFerritinFerrokineticsAntenatal anemiaFerrokinetic indicators

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Gynecol Obstet Invest 2020;85:420–427
https://doi.org/10.1159/000511018

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: April 22, 2020
Accepted: August 19, 2020
Published online: October 02, 2020
Issue release date: December 2020

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 4

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: https://www.karger.com/GOI

Abstract

Objectives: Different forms of anemia are considered as the most frequent complication of the gestational period. By its etiology, pathogenesis, and clinical hematology, it is not a single disease. Among all forms of anemia occurring during pregnancy, iron deficiency anemia (IDA) is the most common, accounting for 80–95% of all cases. Design: The article describes a theoretical basis for the diagnosis of the anemic syndrome among pregnant women, the determining factors of its development, and the diagnostic methods at different gestational periods. Participants/Materials, Setting, and Methods: Diagnostic and prognostic values of iron balance indicators in the body were established for IDA during pregnancy to improve the outcome of childbirth. A total of 140 anemic patients were examined. The control group consisted of 50 pregnant women without anemia and other significant health problems, 48 IDA pregnant women, and 42 pregnant women with anemia caused by various chronic diseases, including rheumatoid arthritis. All patients of the main and control groups were registered on clinical records at the Family Planning Center in Aktobe city, Kazakhstan. Results: Ferrokinetic indicators were suggested for diagnosing IDA and anemia of chronic diseases. It was established that IDA is characterized by low ferritin levels during gestation, while increased ferritin and C-reactive protein are typical for anemia of chronic diseases. Limitations: Differential diagnostics was applied for pregnant women with IDA and anemia of chronic diseases to observe the dynamics of serum ferritin and C-reactive protein (CRP) levels at different gestational periods. The article presents the results of a study on ferrokinetics in pregnant women with IDA and anemia caused by inflammation or chronic diseases. Other causes of anemia leading to a decrease in hemoglobin (Hb) levels to <90 g/L include hemoglobinopathies, which were not considered in this study. Conclusions: Determination of iron deficiency in pregnant women at different gestational periods will allow for identifying the risk group of anemic patients and deciding on the treatment. IDA (Hb <100 g/L) can be effectively measured by ferritin level <15 ng/mL, iron level of <11.5 μmol/L, and transferrin level >2.6 mg/L at p < 0.001. Anemia due to chronic diseases (Hb <100 g/L) can be effectively diagnosed with ferritin above 15 μg/L and CRP above 10 mg/L at p < 0.001.

© 2020 S. Karger AG, Basel



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References

  1. Malinowski AK, D’Souza R, Khan KS, Shehata N, Malinowski M, Daru J. Reported outcomes in perinatal iron deficiency anemia trials: a systematic review. Gynecol Obstet Invest. 2019;84(5):417–34.
    External Resources
  2. Nair M, Choudhury MK, Choudhury SS, Kakoty SD, Sarma UC, Webster P, et al. Association between maternal anaemia and pregnancy outcomes: a cohort study in Assam, India. BMJ Glob Health. 2016;1(1):e000026.
    External Resources
  3. Galazis N, Saso S, Sorbi F, Jones B, Landolfo C, Al-Memar M, et al. Intraoperative ultrasound during fertility-sparing surgery: a systematic review and practical applications. Gynecol Obstet Invest. 2020;85(2):127–48.
    External Resources
  4. Tuhtasinovna HM. Indicators correlation among ferrokinetic performance, copper content in blood serum ceruloplasmin women with extended wear intrauterine device. Eur Sci Rev. 2016;1–2:117–20.
  5. Sangkhae V, Nemeth E. Placental iron transport: the mechanism and regulatory circuits. Free Radic Biol Med. 2019;133:254–61.
    External Resources
  6. Rahmati S, Azami M, Badfar G, Parizad N, Sayehmiri K. The relationship between maternal anemia during pregnancy with preterm birth: a systematic review and meta-analysis. J Matern-Fetal Neo Med. 2019;1:1–11.
  7. Kumari S, Garg N, Kumar A, Guru PKI, Ansari S, Anwar S, et al. Maternal and severe anaemia in delivering women is associated with risk of preterm and low birth weight: a cross sectional study from Jharkhand, India. One Health. 2019;8:100098.
    External Resources
  8. Bikbov MM, Kazakbaeva GM, Zainullin RM, Salavatova VF, Gilmanshin TR, Yakupova DF, et al. Prevalence and associated factors of anemia in a Russian population: the ural eye and medical study. BMC Public Health. 2019;19(1):762.
    External Resources
  9. Morikawa M, Yamada T, Nakagawa K, Hosokawa-Miyanishi A, Umazume T, Chiba K, et al. Maternal anemia and coagulation/fibrinolysis after fetoscopic laser photocoagulation for twin-to-twin transfusion syndrome. Gynecol Obstet Invest. 2019;84(5):477–84.
    External Resources
  10. Indira U, Belginova S, Ismukhamedova A. Informational and analytical system to diagnose anemia. 2018. Vol. 1; p. 1–8.
  11. Figueiredo ACMG, Gomes-Filho IS, Batista JET, Orrico GS, Porto ECL, Cruz Pimenta RM, et al. Maternal anemia and birth weight: a prospective cohort study. PLoS One. 2019;14(3):e0212817.
    External Resources
  12. Nunthapiwat S, Sekararithi R, Wanapirak C, Sirichotiyakul S, Tongprasert F, Srisupundit K, et al. Second trimester serum biomarker screen for fetal aneuploidies as a predictor of preterm delivery: a population-based study. Gynecol Obstet Invest. 2019;84(4):326–33.
    External Resources
  13. Raveendran AV, Shiji PV, Rajini P, Al Qassabi FS. Iron deficiency anemia: an update. BMH Medical. 2019;6(4):116–30.
  14. Homri NKH. Sudan University of Science and Technology; 2018.
  15. Roy NBA, Babbs C. The pathogenesis, diagnosis and management of congenital dyserythropoietic anaemia type I. Br J Haematol. 2019;185(3):436–49.
    External Resources
  16. Rivella S. Iron metabolism under conditions of ineffective erythropoiesis in β-thalassemia. Blood. 2019;133(1):51–8.
    External Resources
  17. Schmidt PJ, Liu K, Visner G, Fitzgerald K, Fishman S, Racie T, et al. RNAi-mediated reduction of hepatic Tmprss6 diminishes anemia and secondary iron overload in a splenectomized mouse model of β-thalassemia intermedia. Am J Hematol. 2018;93(6):745–50.
    External Resources
  18. Valencia-Ortega J, Zárate A, Saucedo R, Hernández-Valencia M, Cruz JG, Puello E. Placental proinflammatory state and maternal endothelial dysfunction in preeclampsia. Gynecol Obstet Invest. 2019;84(1):12–9.
    External Resources
  19. Fisher AL, Nemeth E. Iron homeostasis during pregnancy. Am J Clin Nutr. 2017;106(6):1567–74.
    External Resources
  20. Fisher AL, Sangkhae V, Presicce P, Chougnet CA, Jobe AH, Kallapur SG, et al. Fetal and amniotic fluid iron homeostasis in healthy and complicated murine, macaque, and human pregnancy. JCI Insight. 2020;5(4):135321.
    External Resources
  21. Indarto D, Wiboworini B, Ayusari A, Restuti A, Alfiyah I, Puspita A, et al. Novel genetic variants of transferrin receptor 2 exon 4 and cytokines profile of anemic and nonanemic pregnant women in central java, Indonesia. Asian Pac J Reprod. 2020;9(1):16–21.
    External Resources
  22. Apple CG, Miller ES, Loftus TJ, Kannan KB, Parvataneni HK, Hagen JE, et al. Impact of injury severity on the inflammatory state and severe anemia. J Surg Res. 2020;248:109–16.
    External Resources
  23. Neroev VV, Saakyan SV, Myakoshina EB, Okhotsimskaya TD, Fadeeva VA. Role of optical coherence tomography angiography in diagnostics of early choroidal melanoma and circumscribed choroidal hemangioma. Vestn Oftalmol. 2018;134(3):4–18.
    External Resources
  24. Sabadash V, Gumnitsky J, Lyuta O, Pochapska I. Thermodynamics of (NH4+) cation adsorption under static conditions. Chem Chem Technol. 2018;12(2):143–6.
  25. Kang SY, Kim H-B, Sunwoo S. Association between anemia and maternal depression: a systematic review and meta-analysis. J Psychiatr Res. 2020;122:88–96.
    External Resources
  26. Demmers MW, Niens M, van der Haar G, van der Zaag-Loonen HJ, Hoffmann JJ, Adriaansen HJ. Functional iron deficiency markers are absent during pregnancy despite evidence of low iron stores. Ann Clin Biochem. 2019;56(4):450–6.
    External Resources
  27. Timmer TC, de Groot R, Rijnhart JJM, Lakerveld J, Brug J, Perenboom CWM, et al. Dietary intake of heme iron is associated with ferritin and hemoglobin levels in dutch blood donors: results from donor insight. Haematologica. 2019;1:1–25.
    External Resources

Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: April 22, 2020
Accepted: August 19, 2020
Published online: October 02, 2020
Issue release date: December 2020

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 4

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: https://www.karger.com/GOI

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2020, Vol.85, No. 5

December 2020

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