Respiration

Thematic Review Series

Immunomodulation in Autoimmune Interstitial Lung Disease

Seeliger B.a · Prasse A.a,b

Author affiliations

aDepartment of Respiratory Medicine, Hannover Medical School and Biomedical Research in End-stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany
bFraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany

Keywords: ImmunomodulationInterstitial lung diseaseImmunosuppression

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Respiration 2020;99:819–829
https://doi.org/10.1159/000511200

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Article / Publication Details

First-Page Preview
Abstract of Thematic Review Series

Received: April 13, 2020
Accepted: August 28, 2020
Published online: December 03, 2020
Issue release date: January 2021

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 2

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: https://www.karger.com/RES

Abstract

Interstitial lung diseases (ILDs) associated with autoimmune or systemic disease are increasingly recognized and our pathophysiological understanding rapidly expanding. Treatment modalities, however, are still mainly driven by established disease-modifying antirheumatic drugs (DMARDs) where, despite decades of experience of their use in the underlying diseases such as rheumatoid arthritis, mostly ret­rospective data exist informing their effect on the course of interstitial lung disease (ILD). In recent years, randomized trials investigating the effects of biological DMARDs (bDMARDs) have been completed or are currently running, generating new treatment options for often relentlessly progressive diseases. Herein, we summarize the evidence and current use of both synthetic DMARDs and bDMARDs in the context of ILDs associated with autoimmune/systemic disease.

© 2020 S. Karger AG, Basel



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Article / Publication Details

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Abstract of Thematic Review Series

Received: April 13, 2020
Accepted: August 28, 2020
Published online: December 03, 2020
Issue release date: January 2021

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 2

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: https://www.karger.com/RES

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2020, Vol.99, No. 10

January 2021

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From the Thematic Review Series: “Immunomodulation in Lung Diseases” Series Editors: Marek Lommatzsch and Stephan F. van Eeden.
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