Cerebrovascular Diseases

Clinical Research in Stroke

MMP9 rs17576 Is Simultaneously Correlated with Symptomatic Intracranial Atherosclerotic Stenosis and White Matter Hyperintensities in Chinese Population

Feng X.a · Yu F.a · Zhou X.a · Liu Z.a · Liao D.a · Huang Q.a · Li X.a · Jin X.b · Xia J.a

Author affiliations

aDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China
bDepartment of Neurology, The Third Xiangya Hospital, Central South University, Changsha, China

Keywords: Symptomatic intracranial atherosclerotic stenosisWhite matter hyperintensitiesMatrix metalloproteinase 9Polymorphism

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Cerebrovasc Dis 2021;50:4–11
https://doi.org/10.1159/000511582

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Article / Publication Details

First-Page Preview
Abstract of Clinical Research in Stroke

Received: March 11, 2020
Accepted: September 12, 2020
Published online: December 09, 2020
Issue release date: February 2021

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 5

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: https://www.karger.com/CED

Abstract

Purpose: The aim of this study was screening for single nucleotide polymorphisms (SNPs) associated with white matter hyperintensities (WMHs) in symptomatic intracranial atherosclerotic stenosis (sICAS) patients and exploring a possible connection in the genetic background between macrovascular disease and small vessel disease. Methods: There were 400 sICAS patients enrolled in the study. Fazekas scores were applied to WMH classification. Healthy controls were referred to 1,000 Genome Project and GeneSky company who provided 1,007 Chinese healthy controls. Fast target sequencing technology was used to select the SNPs of 102 genes related to the pathogenesis of sICAS in the sICAS patients. Results: The allele frequencies of 88 SNPs were significantly different between the sICAS group and the healthy controls (p < 0.05). The allele frequencies of 53 SNPs were significantly different between the sICAS patients with and without WMHs (p < 0.05). Further analysis found that matrix metalloproteinase 9 (MMP9) rs17576 was simultaneously related to sICAS and WMHs. The frequency of the rs17576 A allele was significantly lower in sICAS patients when compared to the normal controls (p = 0.03, OR [95% CI] = 0.75 [0.625–0.91]). Also, the frequency of the rs17576 genotypes was significantly different under codominant (p = 0.009), dominant (p = 0.014), and recessive (p= 0.023) models. The frequency of the rs17576 A allele was significantly higher in sICAS with WMH patients, compared to those without WMHs (p = 0.022, OR [95% CI] = 1.54 [1.06–2.22]); the frequency of the rs17576 genotypes was significantly different under codominant (p = 0.019) and recessive (p = 0.032) models. Logistic regression analysis showed that age, hypertension, and MMP9 rs17576 AA genotype were independent risk factors for sICAS with WMHs. Conclusion: MMP9 rs17576 may be simultaneously associated with the risk of sICAS and WMHs.

© 2020 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Clinical Research in Stroke

Received: March 11, 2020
Accepted: September 12, 2020
Published online: December 09, 2020
Issue release date: February 2021

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 5

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: https://www.karger.com/CED

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