Dementia and Geriatric Cognitive Disorders

Original Research Article

Is There a Typical Pattern of Brain SPECT Imaging in Alzheimer’s Disease?

Steinling M.a · Defebvre L.b · Duhamel A.c · Lecouffe P.a · Lavenu I.b · Pasquier F.b · Charpentier P.a,b

Author affiliations

aUnit ‘Brain Functional Imaging’, bNeurological Department and cCentre d’Etudes et de Recherches en Informatique Médicale, University Hospital, CHRU de Lille, Faculté de Médecine, Université de Lille-II, Lille, France

Keywords: Single-photon emission computed tomographyPositron emission tomographyNeurodegenerative dementia

Related Articles for ""
Dement Geriatr Cogn Disord 2001;12:371–378
https://doi.org/10.1159/000051283

Log in to MyKarger to check if you already have access to this content.




Forgot your password
Sign up to MyKarger

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more
CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!


If you would like to redeem your KAB credit, please log in.

Save over 20% compared to the individual article price.

Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates

Select
* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: October 10, 2001
Issue release date: November – December

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

Abstract

The identification of new nosological forms such as Lewy body disease (LBD) requires a re-evaluation of the patterns observed in brain functional imaging in the various forms of dementia. We studied 60 demented patients, divided into three groups and fulfilling the clinical criteria for Alzheimer’s disease (AD), LBD and frontotemporal dementia (FTD), using Tc-HMPAO and a brain-dedicated SPECT system. After normalisation we applied a cut-off at two levels according to previously established criteria. We reaffirmed the already established data concerning FTD (mainly a bilateral frontal decrease) and for LBD (a severe diffuse decrease in the frontal regions and also in the posterior association cortex). In contrast, the decrease in AD was strictly limited to the parieto-occipital cortex, irrespective of the severity of the cognitive decline. We hypothesise that the major simplification concerning the pattern observed in AD can be explained by the fact that patients suffering from LBD have previously been included in the groups of AD patients.

© 2001 S. Karger AG, Basel



Related Articles:

References

  1. Neary D, Snowden JS, Shields RA, Burjan AW, Northen B, MacDermott N, Prescott MC, Testa HJ: Single-photon emission tomography using 99mTc-HMPAO in the investigation of dementia. J Neurol Neurosurg Psychiatry 1987;50:1101–1109.
    External Resources
  2. Derouesné C, Rancurel G, Le Poncin Lafitte M, Rapin JR, Lassen NA: Variability of cerebral blood flow defects in Alzheimer’s disease on 123I-iodo-isopropyl-amphetamine and single photon emission tomography. Lancet 1985;i:1282.
  3. Holman BL, Johnson KA, Gerada B, Carvalho PA, Satlin A: The scintigraphic appearance of Alzheimer’s disease: A prospective study using technetium-99m-HmPAO SPECT. J Nucl Med 1992;33:181–185.
    External Resources
  4. Scheltens P, Vermersch P, Leys D: Heterogeneity of Alzheimer’s disease. Rev Neurol 1993;149:14–25.
  5. Ritchie K, Touchon J: Heterogeneity in senile dementia of the Alzheimer type: Individual differences, progressive deterioration or clinical sub-types? J Clin Epidemiol 1992;45:1391–1398.
    External Resources
  6. Waldemar G: Functional brain imaging with SPECT in normal aging and dementia. Cereb Brain Metab Rev 1995;7:89–130.
    External Resources
  7. Müller H, Möller HJ, Stippel A, Fric M, Grünwald F, Laux G, Klemm E, Biersack HJ: SPECT patterns in probable Alzheimer’s disease. Eur Arch Psychiatry Clin Neurosci 1999;249:190–196.
    External Resources
  8. Guyot M: Classification des démences. Méd Nucl 1998;22:319–324.
  9. Dubois B, Habert MO: Les démences dégénératives: aspects nosologiques et résultats de la tomographie d’émission monophotonique. Méd Nucl 1999;23:613–620.
  10. Defebvre L, Leduc V, Duhamel A, Lecouffe P, Pasquier F, Lamy-Lhullier C, Steinling M, Destée A: Technetium HmPAO SPECT study in dementia with Lewy bodies, Alzheimer’s disease and idiopathic Parkinson’s disease. J Nucl Med 1999;40:956–962.
    External Resources
  11. Charpentier P, Lavenu I, Duhamel A, Pasquier F, Defebvre L, Steinling M: Tc-HMPAO SPECT in differential diagnosis between fronto-temporal dementia and Alzheimer’s disease: Joint Congress EANM and WFNMB, Berlin, September 1998. Eur J Nucl 1998;25:909.
  12. McKahn G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer’s disease: Report of the NINCDS-ADRDA Work Group. Neurology 1984;34:939–944.
    External Resources
  13. McKeith IG, Galasko D, Kosaka K, Perry EK, Dickson DW, Hansen LA, Salmon DP, Lowe J, Mirra SS, Byrne EJ, Lennox G, Quinn NP, Edwardson JA, Ince PG, Bergeron C, Burns A, Miller BL, Lovestone S, Collerton D, Jansen EN, Ballard C, de Vos RA, Wilcock GK, Jellinger KA, Perry RH: Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium of DLB international workshop. Neurology 1996;47:1113–1124.
    External Resources
  14. Brun A, Englund N, Gustafson L, Passant U, Mann DMA, Neary D, Snowden JS: Clinical and neuropathological criteria for fronto-temporal dementia. J Neurol Neurosurg Psychiatry 1994;57:416–418.
    External Resources
  15. Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, Black S, Freedman M, Kertesz A, Robert P, Albert M, Boone K, Miller BL, Cummings J, Benson DF: Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria. Neurology 1998;51:1546–1554.
    External Resources
  16. Steinling M, Leys D, Amegassi F, Gaudet Y, Salomez JL, Ovelacq E, Petit H, Vergnes R: Assessment of dementia with HmPAO-Tc: Which is the best reference for the quantification? in Schmidt HAE, Chambron J (eds): Nuclear Medicine: Quantitative Analysis in Imaging and Function. Stuttgart, Schattauer, 1989, pp 349–351.
  17. Steinling M, Leys D, Amegassi F, Soetart G, Vergnes R: Can Alzheimer and multiinfarct dementia be differentiated using 99mTc-HmPAO tomograms? in Bès A, Géraud G (eds): Circulation cérébrale et vieillissement. London/Paris, Libbey, 1990, pp 291–294.
  18. American Academy of Neurology: Assessment of brain SPECT: Report of the Therapeutics and Technology Assessment subcommittee of the American Academy of Neurology. Neurology 1996;46:278–285.
    External Resources
  19. Jagust WJ, Reed BR, Seab JP, Kramer JH, Budinger TF: Clinical-physiologic correlates of Alzheimer’s disease and frontal lobe dementia. Am J Physiol Imag 1989;4:89–96.
    External Resources
  20. Habert MO, Spampinato U, Mas JL, Piketty ML, Bourdel MC, de Recondo J, Rondot P, Askienazy S: A comparative technetium-99m hexamethylpropylene amine oxime SPECT study in different types of dementia. Eur J Nucl Med 1991;18:3–11.
    External Resources
  21. Miller BL, Cummings JL, Villanueva-Meyer J, Boone K, Mehringer CM, Lesser IM, Mena I: Frontal lobe degeneration: Clinical, neuropsychological, and SPECT characteristics. Neurology 1991;41:1374–1382.
    External Resources
  22. Jagust WH, Johnson KA, Holman BL: SPECT perfusion imaging in the diagnosis of dementia. J Neuroimag 1995;5:S45–S52.
    External Resources
  23. Starkstein SE, Migliorelli R, Teson A, Sabe L, Vazquez S, Turjanski M, Robinson RG, Leiguarda R: Specificity of changes in cerebral blood flow in patients with frontal lobe dementia. J Neurol Neurosurg Psychiatry 1994;57:790–796.
    External Resources
  24. Pasquier F, Lebert F, Lavenu I, Petit H: Diagnostic clinique des démences fronto-temporales. Rev Neurol 1998;154:217–223.
  25. Varma AR, Talbot PR, Snowden JS, Lloyd JJ, Testa HJ, Neary DA: A 99mTc-HMPAO single-photon emission computed tomography study of Lewy body disease. J Neurol 1997;244:349–359.
    External Resources
  26. Albin RL, Minoshima S, D’Amato CJ, Frey KA, Kuhl DA, Sima AAF: Fluorodeoxyglucose positron emission tomography in diffuse Lewy body disease. Neurology 1996;47:462–466.
    External Resources
  27. Leduc V, Lecouffe P, Defebvre L, Pasquier F, Destée A, Steinling M: Comparison of HMPAO-Tc spect study in Parkinson’s disease, Alzheimer’s disease and diffuse Lewy body disease: European Association of Nuclear Medicine Congress, Glasgow, August 1997. Eur J Nucl Med 1997;24:P143.
    External Resources
  28. Minoshima S, Foster NL, Frey KA, Albin RL, Sima AA, Berent S, Kuhl DE: Metabolic differences in Alzheimer’s disease with and without cortical Lewy bodies as revealed by PET. J Cereb Blood Flow Metab 1997;17:S437.
  29. Steinling M, Kassiotis P, Mazingue A, Rousseaux M, Jomin M, Leys D, Dubois P, Fialdes P, Ovelacq E, Vergnes R: Tomographical use of Tc hexamethylpropylene amine-oxime: First experience (78 studies). Press Méd 1988;17:1565–1569.
    External Resources
  30. Leys D, Steinling M: Alzheimer’s disease: Study by single photon emission tomography. Rev Neurol 1989;145:443–450.
  31. Testa HJ, Snowden JS, Neary D, Shields RA, Burjan AW, Prescott MC, Northen B, Goulding P: The use of (99mTc)-HMPAO in the diagnosis of primary degenerative dementia. J Cereb Blood Flow Metab 1998;8:S123–S126.
  32. Brun A, Englund E: Regional pattern of degeneration in Alzheimer’s disease: Neuronal loss and histopathological grading. Histopathology 1981;5:549–564.
    External Resources
  33. Waldemar G, Bruhn P, Kristensen M, Johnsen A, Paulson OB, Lassen NA: Heterogeneity of neocortical cerebral blood flow deficits in dementia of the Alzheimer’s type: A [99mTc]-d,l-HMPAO SPECT study. J Neurol Neurosurg Psychiatry 1994;57:285–295.
    External Resources
  34. Talbot PR, Testa HJ: The value of SPECT imaging in dementia. Nucl Med Commun 1995;16:425–437.
    External Resources
  35. Claus JJ, van Harskamp F, Breteler M, Krenning EP, de Koning I, van der Cammen T, Hofman A, Hasan D: The diagnostic value of SPECT with Tc 99m HMPAO in Alzheimer’s disease: A population-based study. Neurology 1994;44:454–461.
    External Resources
  36. Jobst KA, Barnetson LP, Shepstone BJ: Accurate prediction of histologically confirmed Alzheimer’s NINCDS-ADRDA and DSM-III-R criteria, SPECT, X-ray CT, and Apo E4 medial temporal lobe dementias: The Oxford project to investigate memory and aging. Int Psychogeriatr 1997;9:191–222.
    External Resources
  37. Hoffman JM, Welsh-Bohmer KA, Hanson M, Crain B, Hulette C, Earl N, Coleman RE: FDG PET imaging in patients with pathologically verified dementia. J Nucl Med 2000;41:1920–1928.
    External Resources
  38. Henon H, Pasquier F, Durieu I, Godefroy O, Lucas C, Lebert F, Leys D: Preexisting dementia in stroke patients: Baseline frequency, associated factors, and outcome. Stroke 1997;28:2429–2436.
    External Resources
  39. Gueguen B, Touchon J, Campion D: Troubles de la mémoire chez le sujet âgé: examens complémentaires – pour qui? Thérapie 1997;52:499–502.
  40. Talbot PR, Lloyd JJ, Snowden JS, Neary D, Testa HJ: A clinical role for 99mTc-HMPAO SPECT in investigation of dementia. J Neurol Neurosurg Psychiatry 1998;64:306–313.
    External Resources

Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: October 10, 2001
Issue release date: November – December

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Article Tools
Article Details

2001, Vol.12, No. 6

November – December

Article

Recommend This
TOP