Digestive Diseases

Review Article

Critical Review of Acid Suppression in Nonvariceal, Acute, Upper Gastrointestinal Bleeding

Yacyshyn B.R. · Thomson A.B.R.

Author affiliations

Department of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, Alta., Canada

Keywords: Gastrointestinal bleedingProton pump inhibitors

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Dig Dis 2000;18:117–128
https://doi.org/10.1159/000051385

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Article / Publication Details

First-Page Preview
Abstract of Review Article

Published online: March 04, 2001
Issue release date: 2000

Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 6

ISSN: 0257-2753 (Print)
eISSN: 1421-9875 (Online)

For additional information: https://www.karger.com/DDI

Abstract

Nonvariceal, upper gastrointestinal (GI) bleeding is a very common source of morbidity and mortality. The concept of ulcer clot dissolution being facilitated by a low gastric pH has allowed us to better understand the pathophysiology of nonvariceal upper GI bleeding. Placebo-controlled trials have shown the benefit of oral proton pump inhibitor administration in contrast to H2 receptor antagonists. Furthermore, our recent experience with intravenous proton pump inhibitors has reinforced these observations.



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Article / Publication Details

First-Page Preview
Abstract of Review Article

Published online: March 04, 2001
Issue release date: 2000

Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 6

ISSN: 0257-2753 (Print)
eISSN: 1421-9875 (Online)

For additional information: https://www.karger.com/DDI

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