Chemotherapy

Original Paper

 Focus Article

Analysis of Three Mutations in Italian Strains of SARS-CoV-2: Implications for Pathogenesis

Benvenuto D.a · Benedetti F.b · Demir A.B.c · Ciccozzi M.a · Zella D.b

Author affiliations

aMedical Statistic and Molecular Epidemiology Unit, Campus Bio-Medico University, Rome, Italy
bInstitute of Human Virology and Global Virus Network Center, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA
cDepartment of Medical Biology, School of Medicine, Izmir University of Economics, Izmir, Turkey

Keywords: BioinformaticCoronavirus disease 2019Evolutionary analysisProtein modelingSyndrome coronavirus 2

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Chemotherapy 2021;66:33–37
https://doi.org/10.1159/000515342

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 25, 2021
Accepted: January 28, 2021
Published online: March 18, 2021
Issue release date: June 2021

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 0

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: https://www.karger.com/CHE

Abstract

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped virus initially detected in Wuhan in December 2019, responsible for coronavirus disease 2019 (COVID-19), a respiratory syndrome currently affecting >220 countries around the world, with >80 million cases registered and >1.8 million deaths. Objective: As several vaccines are still being developed and 2 have been approved, it is particularly important to perform evolutionary surveillance to identify mutations potentially affecting vaccine efficacy. Methods: DynaMut server has been used to evaluate the impact of the mutation found on SARS-CoV-2 isolates available on GISAID. Results: In this article, we analyze whole genomes sequenced from Italian patients, and we report the characterization of 3 mutations, one of which presents in the spike protein. Conclusion: The mutations analyzed in this article can be useful to evaluate the evolution of SARS-CoV-2.

© 2021 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 25, 2021
Accepted: January 28, 2021
Published online: March 18, 2021
Issue release date: June 2021

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 0

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: https://www.karger.com/CHE

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2021, Vol.66, No. 1-2

June 2021

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Additional Information

Domenico Benvenuto and Francesca Benedetti contributed equally to this paper.
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