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Pharmacology and Treatment

Multicenter Randomized Comparative Double-Blind Controlled Clinical Trial of the Safety and Efficacy of Zinc Gluconate versus Minocycline Hydrochloride in the Treatment of Inflammatory Acne vulgaris

Dreno B.a · Moyse D.b · Alirezai M.c · Amblard P.d · Auffret N.e · Beylot C.f · Bodokh I.g · Chivot M.h · Daniel F.i · Humbert P.j · Meynadier J.c · Poli F.k

Author affiliations

aDepartment of Dermatology, CHU Nantes, bStatistician, Paris, cDepartment of Dermatology, Hôpital Saint-Eloi, Montpellier, dDepartment of Dermatology, CHRU Albert-Michallon, Grenoble, eDepartment of Dermatology, Fondation Rothschild, Paris, fDepartment of Dermatology, Hôpital du Haut-Levêque, Bordeaux, gDermatologist, Cannes, hDermatology, Centre Médical Municipal Burgos, Suresnes, iDepartment of Dermatology, Hôpital Saint-Joseph, Paris, jDepartment of Dermatology 1, Hôpital Saint-Jacques, Besançon, and kDepartment of Dermatology, Hôpital Henri-Mondor, Créteil, France

Related Articles for ""

Dermatology 2001;203:135–140

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Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Published online: September 28, 2001
Issue release date: 2001

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: In addition to tetracyclines, zinc may constitute an alternative treatment in inflammatory lesions of acne. Objective: To evaluate the place of zinc gluconate in relation to antibiotics in the treatment of acne vulgaris. Methods: Zinc was compared to minocycline in a multicenter randomized double-blind trial. 332 patients received either 30 mg elemental zinc or 100 mg minocycline over 3 months. The primary endpoint was defined as the percentage of the clinical success rate on day 90 (i.e. more than 2/3 decrease in inflammatory lesions, i.e. papules and pustules). Results: This clinical success rate was 31.2% for zinc and 63.4% for minocycline. Minocycline nevertheless showed a 9% superiority in action at 1 month and one of 17% at 3 months, with respect to the mean change in lesion count. Regarding safety, the majority of the adverse effects of zinc gluconate and of minocycline concerned the gastrointestinal system and weremoderate (5 dropouts with zinc gluconate and 4 with minocycline). Conclusion: Minocycline and zinc gluconate are both effective in the treatment of inflammatory acne, but minocycline has a superior effect evaluated to be 17% in our study.

© 2001 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Published online: September 28, 2001
Issue release date: 2001

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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