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Prostate Cancer

Radiotherapy for PSA Recurrence after Radical Prostatectomy

Vanuytsel L.a · Janssens G.a · van Poppel H.b · Rijnders A.a · Baert L.b

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Departments of aRadiotherapy and bUrology, University Hospitals, Leuven, Belgium

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Eur Urol 2001;39:425–429

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Article / Publication Details

First-Page Preview
Abstract of Prostate Cancer

Published online: April 02, 2001
Issue release date: April 2001

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 0

ISSN: 0302-2838 (Print)
eISSN: 1873-7560 (Online)

For additional information: https://www.karger.com/EUR

Abstract

Objectives: The treatment of patients presenting with an isolated PSA recurrence after radical prostatectomy (RP) remains controversial. The present study aims at assessing the results of salvage radiotherapy (RT), to define prognostic factors and to identify subgroups of patients most suitable for RT with curative intent. Materials and Methods: A retrospective study was performed of 53 patients, diagnosed with a rising PSA after RP, and treated with RT to the prostate bed, between July 1992 and July 1998. Results: On univariate analysis, significant determinants to obtain and maintain a nondetectable PSA (<0.02 ng/ml) were Gleason grade (≤III vs. ≧IV), pre–RT PSA, considered as categorical or continuous variable, and pathological stage, pT (2 vs. 3). Pre–RP PSA (≤10 vs. >10), time interval between surgery and moment of rising PSA and pathological section margin status were not significant. On multivariate analysis, only Gleason grade and pre–RT PSA remained significant. For the patient group with a Gleason grade ≤III the PSA–free survival at 3 years was 75% (±11%) compared to 27% (±9%) for the patients with a Gleason grade ≧IV (p = 0.002). Pre–RT PSA significantly influenced PSA–free survival in the first group, but not in the latter. Conclusion: From the group of RP patients with rising PSA following a postsurgery PSA–free period, subgroups can be defined with a distinctly different probability of obtaining and maintaining nondetectable PSA levels after salvage RT.


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    External Resources
  22. Leibovich BC, Engen DE, Patterson DE, Pisansky TM, Alexander EE, Blute ML, Bergstrahl EJ, Zincke H: Benefit of adjuvant radiation therapy for localized prostate cancer with a positive surgical margin. J Urol 2000; 163:1178–1182.

Article / Publication Details

First-Page Preview
Abstract of Prostate Cancer

Published online: April 02, 2001
Issue release date: April 2001

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 0

ISSN: 0302-2838 (Print)
eISSN: 1873-7560 (Online)

For additional information: https://www.karger.com/EUR


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